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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ALA1
  • cytoplasm
  • mitochondrion
  • alanyl-tRNA aminoacylation
  • alanine-tRNA ligase activity
  • ARO1
  • cytoplasm
  • aromatic amino acid family biosynthetic process
  • shikimate kinase activity
  • 3-dehydroquinate dehydratase activity
  • 3-phosphoshikimate 1-carboxyvinyltransferase activity
  • 3-dehydroquinate synthase activity
  • shikimate 5-dehydrogenase activity
  • DUG1
  • cytoplasm
  • mitochondrion
  • ribosome
  • glutathione catabolic process
  • X-His dipeptidase activity
  • GDH1
  • nucleus
  • cytoplasm
  • glutamate biosynthetic process
  • glutamate dehydrogenase (NADP+) activity
  • HIS4
  • intracellular
  • histidine biosynthetic process
  • phosphoribosyl-ATP diphosphatase activity
  • phosphoribosyl-AMP cyclohydrolase activity
  • histidinol dehydrogenase activity
  • HIS6
  • intracellular
  • histidine biosynthetic process
  • 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
  • HRD1
  • endoplasmic reticulum membrane
  • ER-associated protein catabolic process
  • ubiquitin-protein ligase activity
  • MET6
  • cytoplasm
  • methionine biosynthetic process
  • 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • RAD14
  • nucleotide-excision repair factor 1 complex
  • nucleus
  • nucleotide-excision repair, DNA damage recognition
  • zinc ion binding
  • damaged DNA binding
  • SCP160
  • endoplasmic reticulum membrane
  • polysome
  • nuclear membrane-endoplasmic reticulum network
  • meiotic telomere clustering
  • intracellular mRNA localization
  • response to drug
  • chromosome segregation
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • RNA binding
  • G-protein alpha-subunit binding
  • SPE3
  • nucleus
  • cytoplasm
  • pantothenate biosynthetic process
  • spermidine biosynthetic process
  • spermidine synthase activity
  • SPE4
  • cytoplasm
  • pantothenate biosynthetic process
  • spermine biosynthetic process
  • spermine synthase activity
  • TIM11
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
  • ATP synthesis coupled proton transport
  • structural molecule activity
  • URA6
  • nucleus
  • cytoplasm
  • 'de novo' pyrimidine base biosynthetic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • uridine kinase activity
  • YLF2
  • mitochondrion
  • biological_process
  • GTP binding
  • YRB2
  • nucleus
  • nuclear pore
  • ribosomal small subunit export from nucleus
  • protein export from nucleus
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleotide-excision repair factor 1 complex 8.0849E-3 17 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular amino acid and derivative metabolic process 3.0631E-9 17 243 9 6292
    cellular nitrogen compound biosynthetic process 3.5399E-9 17 247 9 6292
    amine biosynthetic process 1.436E-8 17 122 7 6292
    small molecule biosynthetic process 2.6156E-8 17 310 9 6292
    cellular amine metabolic process 3.9157E-8 17 222 8 6292
    amine metabolic process 7.9381E-8 17 243 8 6292
    small molecule metabolic process 4.6347E-7 17 760 11 6292
    cellular amino acid metabolic process 8.5869E-6 17 199 6 6292
    cellular amino acid biosynthetic process 9.3002E-6 17 114 5 6292
    carboxylic acid biosynthetic process 2.4467E-5 17 139 5 6292
    organic acid biosynthetic process 2.4467E-5 17 139 5 6292
    polyamine biosynthetic process 4.1099E-5 17 4 2 6292
    polyamine metabolic process 1.4316E-4 17 7 2 6292
    organic acid metabolic process 1.581E-4 17 333 6 6292
    oxoacid metabolic process 1.581E-4 17 333 6 6292
    carboxylic acid metabolic process 1.581E-4 17 333 6 6292
    cellular ketone metabolic process 1.9529E-4 17 346 6 6292
    pantothenate biosynthetic process 2.4464E-4 17 9 2 6292
    pantothenate metabolic process 2.4464E-4 17 9 2 6292
    cellular nitrogen compound metabolic process 3.3419E-4 17 1770 12 6292
    nitrogen compound metabolic process 3.7731E-4 17 1791 12 6292
    cellular amino acid derivative metabolic process 5.3527E-4 17 61 3 6292
    cellular biosynthetic process 5.9269E-4 17 1567 11 6292
    biosynthetic process 7.272E-4 17 1602 11 6292
    histidine biosynthetic process 8.0644E-4 17 16 2 6292
    histidine metabolic process 8.0644E-4 17 16 2 6292
    histidine family amino acid metabolic process 8.0644E-4 17 16 2 6292
    histidine family amino acid biosynthetic process 8.0644E-4 17 16 2 6292
    heterocycle metabolic process 9.5019E-4 17 171 4 6292
    cellular biogenic amine biosynthetic process 1.2688E-3 17 20 2 6292
    group transfer coenzyme metabolic process 1.9875E-3 17 25 2 6292
    primary metabolic process 2.4078E-3 17 2896 14 6292
    cellular amino acid derivative biosynthetic process 2.4923E-3 17 28 2 6292
    alanyl-tRNA aminoacylation 2.7018E-3 17 1 1 6292
    coenzyme metabolic process 3.7844E-3 17 120 3 6292
    cellular metabolic process 4.1361E-3 17 3033 14 6292
    cellular biogenic amine metabolic process 4.329E-3 17 37 2 6292
    spermidine metabolic process 5.3968E-3 17 2 1 6292
    spermine metabolic process 5.3968E-3 17 2 1 6292
    meiotic telomere clustering 5.3968E-3 17 2 1 6292
    spermidine biosynthetic process 5.3968E-3 17 2 1 6292
    telomere localization 5.3968E-3 17 2 1 6292
    spermine biosynthetic process 5.3968E-3 17 2 1 6292
    metabolic process 6.562E-3 17 3157 14 6292
    cofactor metabolic process 7.5985E-3 17 154 3 6292
    coenzyme biosynthetic process 9.3809E-3 17 55 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transferase activity, transferring alkyl or aryl (other than methyl) groups 1.4102E-4 17 39 3 6292
    spermine synthase activity 2.7018E-3 17 1 1 6292
    alanine-tRNA ligase activity 2.7018E-3 17 1 1 6292
    glutamate dehydrogenase (NADP+) activity 2.7018E-3 17 1 1 6292
    3-dehydroquinate dehydratase activity 2.7018E-3 17 1 1 6292
    3-dehydroquinate synthase activity 2.7018E-3 17 1 1 6292
    5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity 2.7018E-3 17 1 1 6292
    shikimate 5-dehydrogenase activity 2.7018E-3 17 1 1 6292
    3-phosphoshikimate 1-carboxyvinyltransferase activity 2.7018E-3 17 1 1 6292
    5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity 2.7018E-3 17 1 1 6292
    G-protein alpha-subunit binding 2.7018E-3 17 1 1 6292
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity 2.7018E-3 17 1 1 6292
    spermidine synthase activity 2.7018E-3 17 1 1 6292
    shikimate kinase activity 2.7018E-3 17 1 1 6292
    histidinol dehydrogenase activity 5.3968E-3 17 2 1 6292
    phosphoribosyl-AMP cyclohydrolase activity 5.3968E-3 17 2 1 6292
    X-His dipeptidase activity 5.3968E-3 17 2 1 6292
    uridine kinase activity 5.3968E-3 17 2 1 6292
    NADPH dehydrogenase activity 5.3968E-3 17 2 1 6292
    oxidoreductase activity 5.8421E-3 17 281 4 6292
    carbon-oxygen lyase activity, acting on phosphates 8.0849E-3 17 3 1 6292
    phosphoribosyl-ATP diphosphatase activity 8.0849E-3 17 3 1 6292
    catalytic activity 9.7716E-3 17 2150 11 6292

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