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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BFA1
  • spindle pole body
  • regulation of exit from mitosis
  • mitotic cell cycle spindle orientation checkpoint
  • GTPase activator activity
  • CDC48
  • endoplasmic reticulum membrane
  • nucleus
  • microsome
  • cytosol
  • vesicle fusion
  • apoptosis
  • protein transport
  • ER-associated protein catabolic process
  • cell cycle
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • DOA1
  • nucleus
  • cytoplasm
  • double-strand break repair via nonhomologous end joining
  • ubiquitin cycle
  • ubiquitin-dependent protein catabolic process
  • ubiquitin binding
  • FBP1
  • cytosol
  • gluconeogenesis
  • fructose 1,6-bisphosphate 1-phosphatase activity
  • MRM1
  • mitochondrion
  • rRNA modification
  • rRNA (guanine-N1-)-methyltransferase activity
  • NDT80
  • nuclear chromosome
  • transcription
  • meiosis
  • transcription factor activity
  • NPL4
  • nuclear membrane-endoplasmic reticulum network
  • endoplasmic reticulum
  • ER-associated protein catabolic process
  • molecular_function
  • OTU1
  • nucleus
  • cytoplasm
  • protein deubiquitination
  • ubiquitin cycle
  • regulation of transcription
  • ubiquitin-specific protease activity
  • RDS2
  • nucleus
  • cytoplasm
  • response to xenobiotic stimulus
  • transcription factor activity
  • SHP1
  • nucleus
  • cytoplasm
  • ascospore formation
  • proteasomal ubiquitin-dependent protein catabolic process
  • glycogen metabolic process
  • telomere maintenance
  • protein phosphatase type 1 regulator activity
  • TEM1
  • spindle pole body
  • regulation of exit from mitosis
  • protein binding
  • GTPase activity
  • TUP1
  • nucleus
  • negative regulation of transcription
  • nucleosome positioning
  • general transcriptional repressor activity
  • UBX4
  • nucleus
  • cytoplasm
  • sporulation resulting in formation of a cellular spore
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • UBX5
  • nucleus
  • cytoplasm
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • UBX7
  • nuclear envelope
  • endoplasmic reticulum
  • sporulation resulting in formation of a cellular spore
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • UFD1
  • endoplasmic reticulum
  • protein transport
  • mRNA processing
  • ubiquitin-dependent protein catabolic process
  • protein binding
  • UFD2
  • nucleus
  • cytoplasm
  • ubiquitin cycle
  • response to stress
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • YDR049W
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • YGL108C
  • cellular_component
  • biological_process
  • molecular_function
  • YJR098C
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • YNL155W
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • YOR342C
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoplasm 2.9299E-3 22 3552 19 6292
    intracellular organelle 5.571E-3 22 4070 20 6292
    organelle 5.5941E-3 22 4071 20 6292
    nucleus 8.9348E-3 22 2041 13 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    modification-dependent protein catabolic process 1.0618E-9 22 156 9 6292
    ubiquitin-dependent protein catabolic process 1.0618E-9 22 156 9 6292
    proteolysis involved in cellular protein catabolic process 1.2589E-9 22 159 9 6292
    modification-dependent macromolecule catabolic process 1.6595E-9 22 164 9 6292
    cellular protein catabolic process 2.4078E-9 22 171 9 6292
    proteolysis 5.5789E-9 22 188 9 6292
    protein catabolic process 5.8467E-9 22 189 9 6292
    cellular macromolecule catabolic process 1.1196E-7 22 265 9 6292
    ubiquitin cycle 1.4811E-7 22 4 3 6292
    macromolecule catabolic process 2.733E-7 22 294 9 6292
    cellular catabolic process 4.9818E-6 22 415 9 6292
    catabolic process 2.1435E-5 22 496 9 6292
    obsolete_biological_process 1.116E-3 22 60 3 6292
    proteasomal protein catabolic process 1.6743E-3 22 69 3 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.6743E-3 22 69 3 6292
    cellular protein metabolic process 1.7954E-3 22 1074 10 6292
    protein metabolic process 2.7834E-3 22 1136 10 6292
    exit from mitosis 3.335E-3 22 25 2 6292
    regulation of exit from mitosis 3.335E-3 22 25 2 6292
    ER-associated protein catabolic process 7.9973E-3 22 39 2 6292
    sporulation 8.9459E-3 22 125 3 6292
    sporulation resulting in formation of a cellular spore 8.9459E-3 22 125 3 6292
    anatomical structure formation involved in morphogenesis 9.7514E-3 22 129 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    fructose 1,6-bisphosphate 1-phosphatase activity 3.4965E-3 22 1 1 6292
    rRNA (guanine-N1-)-methyltransferase activity 3.4965E-3 22 1 1 6292
    general transcriptional repressor activity 6.9813E-3 22 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle