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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 510.180.10.30
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CCL1
  • mitochondrion
  • holo TFIIH complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
  • cyclin-dependent protein kinase regulator activity
  • general RNA polymerase II transcription factor activity
  • KIN28
  • holo TFIIH complex
  • protein amino acid phosphorylation
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter
  • cyclin-dependent protein kinase activating kinase activity
  • RNA polymerase II carboxy-terminal domain kinase activity
  • general RNA polymerase II transcription factor activity
  • cyclin-dependent protein kinase activity
  • RAD2
  • nucleotide-excision repair factor 3 complex
  • nucleotide-excision repair, DNA incision, 3'-to lesion
  • nucleotide-excision repair
  • single-stranded DNA specific endodeoxyribonuclease activity
  • RAD3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • DNA helicase activity
  • general RNA polymerase II transcription factor activity
  • SSL1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • SSL2
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter
  • DNA helicase activity
  • general RNA polymerase II transcription factor activity
  • TFB1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB2
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    holo TFIIH complex 6.6754E-24 9 10 8 6292
    nucleotide-excision repair factor 3 complex 4.663E-22 9 7 7 6292
    nucleotide-excision repair complex 5.401E-17 9 21 7 6292
    DNA-directed RNA polymerase II, holoenzyme 2.0935E-16 9 56 8 6292
    transcription factor complex 1.5646E-15 9 71 8 6292
    nucleoplasm part 4.1137E-11 9 245 8 6292
    nucleoplasm 7.5193E-11 9 264 8 6292
    nuclear lumen 5.7468E-9 9 453 8 6292
    organelle lumen 1.1527E-7 9 660 8 6292
    intracellular organelle lumen 1.1527E-7 9 660 8 6292
    nuclear part 1.5218E-7 9 1103 9 6292
    membrane-enclosed lumen 1.8386E-7 9 700 8 6292
    protein complex 2.0019E-7 9 1137 9 6292
    macromolecular complex 5.3146E-6 9 1635 9 6292
    nucleus 3.9292E-5 9 2041 9 6292
    organelle part 1.0749E-4 9 2282 9 6292
    intracellular organelle part 1.0749E-4 9 2282 9 6292
    membrane-bounded organelle 9.9391E-3 9 3771 9 6292
    intracellular membrane-bounded organelle 9.9391E-3 9 3771 9 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    negative regulation of transcription from RNA polymerase II promoter, mitotic 3.7293E-21 9 8 7 6292
    regulation of transcription from RNA polymerase II promoter, mitotic 3.7293E-21 9 8 7 6292
    regulation of transcription, mitotic 1.6777E-20 9 9 7 6292
    negative regulation of transcription, mitotic 1.6777E-20 9 9 7 6292
    nucleotide-excision repair, DNA duplex unwinding 9.7705E-19 9 6 6 6292
    transcription initiation from RNA polymerase II promoter 4.6403E-17 9 47 8 6292
    transcription initiation 2.8241E-16 9 58 8 6292
    nucleotide-excision repair 5.8341E-15 9 38 7 6292
    DNA geometric change 3.7654E-14 9 20 6 6292
    DNA duplex unwinding 3.7654E-14 9 20 6 6292
    negative regulation of transcription from RNA polymerase II promoter 1.7744E-13 9 60 7 6292
    protein complex biogenesis 9.9918E-13 9 155 8 6292
    protein complex assembly 9.9918E-13 9 155 8 6292
    regulation of transcription from RNA polymerase II promoter 2.2998E-11 9 228 8 6292
    DNA conformation change 3.8711E-11 9 58 6 6292
    macromolecular complex assembly 1.2438E-10 9 281 8 6292
    negative regulation of transcription, DNA-dependent 1.8209E-10 9 157 7 6292
    negative regulation of RNA metabolic process 1.9048E-10 9 158 7 6292
    negative regulation of transcription 2.4808E-10 9 164 7 6292
    negative regulation of gene expression 2.4808E-10 9 164 7 6292
    negative regulation of macromolecule biosynthetic process 3.928E-10 9 175 7 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.7938E-10 9 180 7 6292
    negative regulation of nitrogen compound metabolic process 4.7938E-10 9 180 7 6292
    transcription from RNA polymerase II promoter 5.1178E-10 9 335 8 6292
    negative regulation of biosynthetic process 6.7664E-10 9 189 7 6292
    negative regulation of cellular biosynthetic process 6.7664E-10 9 189 7 6292
    DNA repair 7.5619E-10 9 192 7 6292
    negative regulation of macromolecule metabolic process 7.5619E-10 9 192 7 6292
    macromolecular complex subunit organization 8.5295E-10 9 357 8 6292
    regulation of transcription, DNA-dependent 8.7231E-10 9 358 8 6292
    regulation of RNA metabolic process 9.7502E-10 9 363 8 6292
    negative regulation of cellular metabolic process 1.3753E-9 9 209 7 6292
    negative regulation of metabolic process 1.4223E-9 9 210 7 6292
    regulation of transcription 1.5308E-9 9 384 8 6292
    cellular component assembly 1.563E-9 9 385 8 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.8511E-9 9 415 8 6292
    regulation of nitrogen compound metabolic process 2.9066E-9 9 416 8 6292
    response to DNA damage stimulus 3.232E-9 9 236 7 6292
    negative regulation of cellular process 4.8431E-9 9 250 7 6292
    regulation of gene expression 4.9837E-9 9 445 8 6292
    negative regulation of biological process 5.2656E-9 9 253 7 6292
    regulation of macromolecule biosynthetic process 6.0581E-9 9 456 8 6292
    regulation of cellular biosynthetic process 7.9803E-9 9 472 8 6292
    regulation of biosynthetic process 8.1164E-9 9 473 8 6292
    regulation of macromolecule metabolic process 1.0415E-8 9 488 8 6292
    transcription, DNA-dependent 1.3261E-8 9 503 8 6292
    cellular response to stress 1.3691E-8 9 290 7 6292
    RNA biosynthetic process 1.435E-8 9 508 8 6292
    regulation of primary metabolic process 1.576E-8 9 514 8 6292
    regulation of cellular metabolic process 2.2013E-8 9 536 8 6292
    regulation of metabolic process 2.5882E-8 9 547 8 6292
    transcription 2.7827E-8 9 552 8 6292
    cellular response to stimulus 8.8375E-8 9 379 7 6292
    cellular component biogenesis 1.7172E-7 9 694 8 6292
    regulation of cellular process 5.0877E-7 9 796 8 6292
    response to stress 5.7671E-7 9 497 7 6292
    regulation of biological process 6.6868E-7 9 824 8 6292
    nucleic acid metabolic process 1.4425E-6 9 1415 9 6292
    DNA metabolic process 1.7695E-6 9 585 7 6292
    RNA metabolic process 2.1237E-6 9 954 8 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.6017E-6 9 1566 9 6292
    cellular nitrogen compound metabolic process 1.0872E-5 9 1770 9 6292
    response to stimulus 1.1142E-5 9 766 7 6292
    cellular macromolecule biosynthetic process 1.1802E-5 9 1187 8 6292
    macromolecule biosynthetic process 1.1959E-5 9 1189 8 6292
    nitrogen compound metabolic process 1.2092E-5 9 1791 9 6292
    biological regulation 1.3981E-5 9 1213 8 6292
    gene expression 2.1668E-5 9 1283 8 6292
    cellular biosynthetic process 1.0243E-4 9 1567 8 6292
    cellular macromolecule metabolic process 1.0877E-4 9 2285 9 6292
    cellular component organization 1.1027E-4 9 1582 8 6292
    biosynthetic process 1.2151E-4 9 1602 8 6292
    macromolecule metabolic process 1.3953E-4 9 2349 9 6292
    primary metabolic process 9.2081E-4 9 2896 9 6292
    cellular metabolic process 1.3966E-3 9 3033 9 6292
    nucleotide-excision repair, DNA incision, 3'-to lesion 1.4304E-3 9 1 1 6292
    metabolic process 2.004E-3 9 3157 9 6292
    nucleotide-excision repair, DNA incision 4.2857E-3 9 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    general RNA polymerase II transcription factor activity 6.5157E-16 9 64 8 6292
    RNA polymerase II transcription factor activity 2.3684E-13 9 130 8 6292
    transcription regulator activity 5.6299E-10 9 339 8 6292
    DNA helicase activity 9.9648E-4 9 34 2 6292
    RNA polymerase II carboxy-terminal domain kinase activity 1.4304E-3 9 1 1 6292
    protein kinase regulator activity 1.8221E-3 9 46 2 6292
    kinase regulator activity 2.0657E-3 9 49 2 6292
    cyclin-dependent protein kinase activating kinase activity 2.859E-3 9 2 1 6292
    helicase activity 5.8284E-3 9 83 2 6292
    single-stranded DNA specific endodeoxyribonuclease activity 9.9746E-3 9 7 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle