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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • SPB4
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.008E-32 21 211 21 6292
    nuclear lumen 6.5099E-25 21 453 21 6292
    organelle lumen 2.0452E-21 21 660 21 6292
    intracellular organelle lumen 2.0452E-21 21 660 21 6292
    membrane-enclosed lumen 7.1685E-21 21 700 21 6292
    non-membrane-bounded organelle 5.7857E-18 21 959 21 6292
    intracellular non-membrane-bounded organelle 5.7857E-18 21 959 21 6292
    nuclear part 1.1242E-16 21 1103 21 6292
    nucleus 5.0329E-11 21 2041 21 6292
    intracellular organelle part 5.3026E-10 21 2282 21 6292
    organelle part 5.3026E-10 21 2282 21 6292
    preribosome, large subunit precursor 1.1434E-8 21 9 4 6292
    Noc complex 3.1914E-7 21 5 3 6292
    preribosome 3.9866E-6 21 34 4 6292
    nuclear outer membrane 7.2689E-6 21 86 5 6292
    Noc2p-Noc3p complex 1.0611E-5 21 2 2 6292
    Noc1p-Noc2p complex 1.0611E-5 21 2 2 6292
    nuclear membrane 1.3139E-5 21 97 5 6292
    membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    nuclear envelope 3.3861E-5 21 199 6 6292
    intracellular organelle 1.0447E-4 21 4070 21 6292
    organelle 1.0501E-4 21 4071 21 6292
    outer membrane 2.4114E-4 21 178 5 6292
    organelle outer membrane 2.4114E-4 21 178 5 6292
    nucleolar part 4.1557E-4 21 45 3 6292
    nuclear membrane-endoplasmic reticulum network 8.182E-4 21 232 5 6292
    90S preribosome 1.4001E-3 21 17 2 6292
    endomembrane system 1.4813E-3 21 398 6 6292
    envelope 4.96E-3 21 505 6 6292
    organelle envelope 4.96E-3 21 505 6 6292
    intracellular part 6.1098E-3 21 4938 21 6292
    intracellular 7.149E-3 21 4975 21 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.957E-27 21 346 21 6292
    ribonucleoprotein complex biogenesis 1.0515E-26 21 374 21 6292
    ribosomal large subunit biogenesis 3.902E-24 21 65 14 6292
    cellular component biogenesis 5.9672E-21 21 694 21 6292
    ribosome assembly 1.3391E-11 21 64 8 6292
    organelle assembly 2.5063E-11 21 69 8 6292
    ribonucleoprotein complex assembly 2.6734E-10 21 92 8 6292
    ribosomal large subunit assembly 2.6414E-9 21 41 6 6292
    ribosomal subunit assembly 1.6547E-8 21 55 6 6292
    cellular macromolecular complex assembly 6.2007E-8 21 182 8 6292
    rRNA processing 1.1226E-7 21 128 7 6292
    rRNA metabolic process 1.7943E-7 21 137 7 6292
    cellular macromolecular complex subunit organization 9.4507E-7 21 259 8 6292
    macromolecular complex assembly 1.7552E-6 21 281 8 6292
    ncRNA processing 3.8141E-6 21 215 7 6292
    macromolecular complex subunit organization 1.0527E-5 21 357 8 6292
    ncRNA metabolic process 1.2429E-5 21 257 7 6292
    processing of 27S pre-rRNA 1.7454E-5 21 16 3 6292
    cellular component assembly 1.8356E-5 21 385 8 6292
    establishment of ribosome localization 7.9315E-5 21 26 3 6292
    ribosome localization 7.9315E-5 21 26 3 6292
    ribosomal subunit export from nucleus 7.9315E-5 21 26 3 6292
    RNA processing 1.5389E-4 21 380 7 6292
    cellular process 6.1031E-4 21 4426 21 6292
    establishment of organelle localization 7.52E-4 21 55 3 6292
    obsolete_biological_process 9.7041E-4 21 60 3 6292
    organelle localization 2.6546E-3 21 85 3 6292
    nuclear export 4.5732E-3 21 103 3 6292
    nuclear transport 8.7312E-3 21 130 3 6292
    nucleocytoplasmic transport 8.7312E-3 21 130 3 6292
    RNA metabolic process 8.7711E-3 21 954 8 6292
    actomyosin structure organization 9.9809E-3 21 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 9.9809E-3 21 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 9.9809E-3 21 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 1.7831E-6 21 28 4 6292
    RNA-dependent ATPase activity 2.0639E-6 21 29 4 6292
    RNA helicase activity 9.4563E-6 21 42 4 6292
    ATP-dependent helicase activity 1.6226E-5 21 48 4 6292
    purine NTP-dependent helicase activity 1.6226E-5 21 48 4 6292
    helicase activity 1.4203E-4 21 83 4 6292
    rRNA binding 1.2379E-3 21 16 2 6292
    ATPase activity, coupled 1.3204E-3 21 149 4 6292
    ribosomal large subunit binding 3.3376E-3 21 1 1 6292
    nucleoside-triphosphatase activity 3.8531E-3 21 329 5 6292
    ATPase activity 4.695E-3 21 211 4 6292
    hydrolase activity, acting on acid anhydrides 5.2116E-3 21 353 5 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 5.2116E-3 21 353 5 6292
    pyrophosphatase activity 5.2116E-3 21 353 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle