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Protein Overview: SGS1

General Information:
Name(s) found: SGS1 / YMR190C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Nucleolar DNA helicase of the RecQ family involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1447 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    RecQ helicase-Topo III complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: meiotic chromosome segregation [IMPLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    telomere maintenance via recombination [IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    replicative cell aging [IMPLink to PubMed articleLink to PubMed article]
    DNA unwinding involved in replication [IDALink to PubMed article]
    Molecular Function: ATP-dependent DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTKPSHNLR REHKWLKETA TLQEDKDFVF QAIQKHIANK RPKTNSPPTT PSKDECGPGT  60
   61 TNFITSIPAS GPTNTATKQH EVMQTLSNDT EWLSYTATSN QYADVPMVDI PASTSVVSNP 120
  121 RTPNGSKTHN FNTFRPHMAS SLVENDSSRN LGSRNNNKSV IDNSSIGKQL ENDIKLEVIR 180
  181 LQGSLIMALK EQSKLLLQKC SIIESTSLSE DAKRLQLSRD IRPQLSNMSI RIDSLEKEII 240
  241 KAKKDGMSKD QSKGRSQVSS QDDNIISSIL PSPLEYNTSS RNSNLTSTTA TTVTKALAIT 300
  301 GAKQNITNNT GKNSNNDSNN DDLIQVLDDE DDIDCDPPVI LKEGAPHSPA FPHLHMTSEE 360
  361 QDELTRRRNM RSREPVNYRI PDRDDPFDYV MGKSLRDDYP DVEREEDELT MEAEDDAHSS 420
  421 YMTTRDEEKE ENELLNQSDF DFVVNDDLDP TQDTDYHDNM DVSANIQESS QEGDTRSTIT 480
  481 LSQNKNVQVI LSSPTAQSVP SNGQNQIGVE HIDLLEDDLE KDAILDDSMS FSFGRQHMPM 540
  541 SHSDLELIDS EKENEDFEED NNNNGIEYLS DSDLERFDEE RENRTQVADI QELDNDLKII 600
  601 TERKLTGDNE HPPPSWSPKI KREKSSVSQK DEEDDFDDDF SLSDIVSKSN LSSKTNGPTY 660
  661 PWSDEVLYRL HEVFKLPGFR PNQLEAVNAT LQGKDVFVLM PTGGGKSLCY QLPAVVKSGK 720
  721 THGTTIVISP LISLMQDQVE HLLNKNIKAS MFSSRGTAEQ RRQTFNLFIN GLLDLVYISP 780
  781 EMISASEQCK RAISRLYADG KLARIVVDEA HCVSNWGHDF RPDYKELKFF KREYPDIPMI 840
  841 ALTATASEQV RMDIIHNLEL KEPVFLKQSF NRTNLYYEVN KKTKNTIFEI CDAVKSRFKN 900
  901 QTGIIYCHSK KSCEQTSAQM QRNGIKCAYY HAGMEPDERL SVQKAWQADE IQVICATVAF 960
  961 GMGIDKPDVR FVYHFTVPRT LEGYYQETGR AGRDGNYSYC ITYFSFRDIR TMQTMIQKDK1020
 1021 NLDRENKEKH LNKLQQVMAY CDNVTDCRRK LVLSYFNEDF DSKLCHKNCD NCRNSANVIN1080
 1081 EERDVTEPAK KIVKLVESIQ NERVTIIYCQ DVFKGSRSSK IVQANHDTLE EHGIGKSMQK1140
 1141 SEIERIFFHL ITIRVLQEYS IMNNSGFASS YVKVGPNAKK LLTGKMEIKM QFTISAPNSR1200
 1201 PSTSSSFQAN EDNIPVIAQK STTIGGNVAA NPPRFISAKE HLRSYTYGGS TMGSSHPITL1260
 1261 KNTSDLRSTQ ELNNLRMTYE RLRELSLNLG NRMVPPVGNF MPDSILKKMA AILPMNDSAF1320
 1321 ATLGTVEDKY RRRFKYFKAT IADLSKKRSS EDHEKYDTIL NDEFVNRAAA SSNGIAQSTG1380
 1381 TKSKFFGANL NEAKENEQII NQIRQSQLPK NTTSSKSGTR SISKSSKKSA NGRRGFRNYR1440
 1441 GHYRGRK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) CMR1 DNA2 HDA1 HDA2 HDA3 HSC82 KAP95 LCD1 MEC1 MGM101 MLH1 MPH1 MSH2 MSH3 MSH6 OLA1 PGK1 PMS1 PRO2 RAD16 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RSC8 RVB2 SGS1 SHS1 TIF1, TIF2 TOP3 VAS1 VPS1 YHR122W
    View Details Ho Y, et al. (2002) HPR1 PSK2 RPN1 SET1 SFP1 SGS1 SUV3 SWD3
    View Details Qiu et al. (2008) SGS1 TOP3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SGS1 NCL1 2 Unpublished Fields Lab Data
    View Screen SGS1 DUN1 2 Unpublished Fields Lab Data
    View Screen SGS1 SEC1 2 Unpublished Fields Lab Data
    View Screen SGS1 TOP3 2 Unpublished Fields Lab Data
    View Screen SGS1 YLR415C 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SGS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] deduced N/A No confident structure predictions are available.
    2 View Details [135..654] MSA 8.466997 View MSA. No confident structure predictions are available.
    3 View Details [655..867] PSI-BLAST 197.9691 Putative DEAD box RNA helicase
    4 View Details [868..1017] PSI-BLAST 197.9691 Putative DEAD box RNA helicase
    5 View Details [1018..1156] PSI-BLAST 14.69897 Nucleotide excision repair enzyme UvrB
    6 View Details [1157..1269] deduced N/A Confident ab initio structure predictions are available.
    7 View Details [1270..1373] PSI-BLAST 405.440336 HRDC domain from RecQ helicase
    8 View Details [1374..1447] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • DNA-directed RNA polymerase activity
    		•  3.24179656806626 bayes_pls_golite062009
  • RNA polymerase activity
    		•  3.24179656806626 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  2.86764755795127 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21457679362657 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.94584323396575 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.94584323396575 bayes_pls_golite062009
  • binding
    		•  1.9212205923594 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.68565168715612 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.46069986266132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.34255479264918 bayes_pls_golite062009
  • catalytic activity
    		•  1.17990683373825 bayes_pls_golite062009
  • hydrolase activity
    		•  1.08890095536803 bayes_pls_golite062009
  • endonuclease activity
    		•  0.876142054476658 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.54480131475963 bayes_pls_golite062009
  • protein binding
    		•  0.497114544861103 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.35631508447468 bayes_pls_golite062009
  • helicase activity
    		•  0.112889920470041 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle