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View Structure Prediction Details

Protein: SGS1
Organism: Saccharomyces cerevisiae
Length: 1447 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SGS1.

Description E-value Query
Range
Subject
Range
SGS1 - Nucleolar DNA helicase of the RecQ family involved in genome integrity maintenance; regulates chromo...
SGS1_YEAST - ATP-dependent helicase SGS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGS1 PE=1 SV...
0.0 [1..1447] [1..1447]
BLM - Bloom syndrome, RecQ helicase-like
0.0 [236..1287] [174..1290]
BLM_XENLA - Bloom syndrome protein homolog OS=Xenopus laevis GN=blm PE=2 SV=1
0.0 [242..1285] [160..1240]
gi|3370996, gi|3... - gi|3370996|dbj|BAA32001.1| mBlm [Mus musculus], gi|31982492|ref|NP_031576.2| Bloom syndrome protein ...
0.0 [241..1305] [175..1311]
RQL4B_ARATH - ATP-dependent DNA helicase Q-like 4B OS=Arabidopsis thaliana GN=RECQL4B PE=2 SV=1
0.0 [420..1283] [216..1110]
HUS2_SCHPO - ATP-dependent DNA helicase hus2/rqh1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rqh1 ...
rqh1 - RecQ type DNA helicase Rqh1
0.0 [435..1445] [271..1290]
gi|9945008 - gi|9945008|gb|AAG03075.1|AF294728_1 Sgs1p [Candida albicans]
0.0 [211..1435] [26..1168]
Q66FY3|Q66FY3_YERPS - ATP-dependent DNA helicase - Yersinia pseudotuberculosis
gi|167048747, gi... - gi|167401854|ref|ZP_02307342.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Antiqua str....
gi|89104204, gi|... - gi|89104204|ref|ZP_01176754.1| COG0514: Superfamily II DNA helicase [Yersinia pestis biovar Oriental...
gi|166213635, gi... - gi|166213635|ref|ZP_02239670.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Antiqua str....
gi|108806187, gi... - gi|108806187|ref|YP_650103.1| ATP-dependent DNA helicase RecQ [Yersinia pestis Antiqua], gi|10877810...
gi|167054800, gi... - gi|167426281|ref|ZP_02318034.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Mediaevalis ...
gi|229682488, gi... - gi|229900469|ref|ZP_04515598.1| ATP-dependent DNA helicase [Yersinia pestis Nepal516], gi|229682488|...
gi|167421077, gi... - gi|167421077|ref|ZP_02312830.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Orientalis s...
gi|167469646 - gi|167469646|ref|ZP_02334350.1| ATP-dependent DNA helicase RecQ [Yersinia pestis FV-1]
gi|21957085, gi|... - gi|22124312|ref|NP_667735.1| ATP-dependent DNA helicase RecQ [Yersinia pestis KIM], gi|21957085|gb|A...
gi|25290798 - pir||AI0466 ATP-dependent DNA helicase (EC 3.6.1.-) [imported] - Yersinia pestis (strain CO92)
gi|51594557, gi|... - gi|51594557|ref|YP_068748.1| ATP-dependent DNA helicase RecQ [Yersinia pseudotuberculosis IP 32953],...
gi|45442967, gi|... - gi|45442967|ref|NP_994506.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Microtus str. 9...
gi|16123968, gi|... - gi|218930836|ref|YP_002348711.1| ATP-dependent DNA helicase RecQ [Yersinia pestis CO92], gi|16123968...
gi|162418857, gi... - gi|162418857|ref|YP_001605148.1| ATP-dependent DNA helicase RecQ [Yersinia pestis Angola], gi|162351...
gi|229706105, gi... - gi|229837162|ref|ZP_04457327.1| ATP-dependent DNA helicase [Yersinia pestis Pestoides A], gi|2297061...
gi|229695888, gi... - gi|229839522|ref|ZP_04459681.1| ATP-dependent DNA helicase [Yersinia pestis biovar Orientalis str. P...
gi|77630731, gi|... - gi|77630731|ref|ZP_00793317.1| COG0514: Superfamily II DNA helicase [Yersinia pseudotuberculosis IP ...
gi|149289417, gi... - gi|153997111|ref|ZP_02022244.1| ATP-dependent DNA helicase [Yersinia pestis CA88-4125], gi|149289417...
gi|165989444, gi... - gi|166011675|ref|ZP_02232573.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Antiqua str....
gi|229900085, gi... - gi|229900085|ref|ZP_04515222.1| ATP-dependent DNA helicase [Yersinia pestis biovar Orientalis str. I...
gi|145600700, gi... - gi|145600700|ref|YP_001164776.1| ATP-dependent DNA helicase RecQ [Yersinia pestis Pestoides F], gi|1...
gi|165921764, gi... - gi|165926240|ref|ZP_02222072.1| ATP-dependent DNA helicase RecQ [Yersinia pestis biovar Orientalis s...
0.0 [662..1275] [7..602]
gi|11352915 - pir||H81794 ATP-dependent DNA helicase (EC 3.6.1.-) NMA2213 [imported] - Neisseria meningitidis (str...
gi|7380832, gi|2... - gi|7380832|emb|CAB85424.1| ATP-dependent DNA helicase [Neisseria meningitidis Z2491], gi|218768944|r...
0.0 [662..1356] [2..702]

Back

Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTKPSHNLR REHKWLKETA TLQEDKDFVF QAIQKHIANK RPKTNSPPTT PSKDECGPGT  60
   61 TNFITSIPAS GPTNTATKQH EVMQTLSNDT EWLSYTATSN QYADVPMVDI PASTSVVSNP 120
  121 RTPNGSKTHN FNTF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [135-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPHMASSLVE NDSSRNLGSR NNNKSVIDNS SIGKQLENDI KLEVIRLQGS LIMALKEQSK  60
   61 LLLQKCSIIE STSLSEDAKR LQLSRDIRPQ LSNMSIRIDS LEKEIIKAKK DGMSKDQSKG 120
  121 RSQVSSQDDN IISSILPSPL EYNTSSRNSN LTSTTATTVT KALAITGAKQ NITNNTGKNS 180
  181 NNDSNNDDLI QVLDDEDDID CDPPVILKEG APHSPAFPHL HMTSEEQDEL TRRRNMRSRE 240
  241 PVNYRIPDRD DPFDYVMGKS LRDDYPDVER EEDELTMEAE DDAHSSYMTT RDEEKEENEL 300
  301 LNQSDFDFVV NDDLDPTQDT DYHDNMDVSA NIQESSQEGD TRSTITLSQN KNVQVILSSP 360
  361 TAQSVPSNGQ NQIGVEHIDL LEDDLEKDAI LDDSMSFSFG RQHMPMSHSD LELIDSEKEN 420
  421 EDFEEDNNNN GIEYLSDSDL ERFDEERENR TQVADIQELD NDLKIITERK LTGDNEHPPP 480
  481 SWSPKIKREK SSVSQKDEED DFDDDFSLSD IVSKSNLSSK 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [655-867]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNGPTYPWSD EVLYRLHEVF KLPGFRPNQL EAVNATLQGK DVFVLMPTGG GKSLCYQLPA  60
   61 VVKSGKTHGT TIVISPLISL MQDQVEHLLN KNIKASMFSS RGTAEQRRQT FNLFINGLLD 120
  121 LVYISPEMIS ASEQCKRAIS RLYADGKLAR IVVDEAHCVS NWGHDFRPDY KELKFFKREY 180
  181 PDIPMIALTA TASEQVRMDI IHNLELKEPV FLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 197.9691
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [868-1017]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSFNRTNLYY EVNKKTKNTI FEICDAVKSR FKNQTGIIYC HSKKSCEQTS AQMQRNGIKC  60
   61 AYYHAGMEPD ERLSVQKAWQ ADEIQVICAT VAFGMGIDKP DVRFVYHFTV PRTLEGYYQE 120
  121 TGRAGRDGNY SYCITYFSFR DIRTMQTMIQ 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 197.9691
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1018-1156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDKNLDRENK EKHLNKLQQV MAYCDNVTDC RRKLVLSYFN EDFDSKLCHK NCDNCRNSAN  60
   61 VINEERDVTE PAKKIVKLVE SIQNERVTII YCQDVFKGSR SSKIVQANHD TLEEHGIGKS 120
  121 MQKSEIERIF FHLITIRVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1d2mA_
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed RNA polymerase activity 3.24179656806626 bayes_pls_golite062009
RNA polymerase activity 3.24179656806626 bayes_pls_golite062009
nucleotidyltransferase activity 2.86764755795127 bayes_pls_golite062009
transcription regulator activity 2.21457679362657 bayes_pls_golite062009
histone acetyltransferase activity 1.94584323396575 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.94584323396575 bayes_pls_golite062009
binding 1.9212205923594 bayes_pls_golite062009
DNA-dependent ATPase activity 1.68565168715612 bayes_pls_golite062009
DNA helicase activity 1.46069986266132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.34255479264918 bayes_pls_golite062009
catalytic activity 1.17990683373825 bayes_pls_golite062009
hydrolase activity 1.08890095536803 bayes_pls_golite062009
endonuclease activity 0.876142054476658 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.54480131475963 bayes_pls_golite062009
protein binding 0.497114544861103 bayes_pls_golite062009
ribonuclease activity 0.35631508447468 bayes_pls_golite062009
helicase activity 0.112889920470041 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1157-1269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEYSIMNNSG FASSYVKVGP NAKKLLTGKM EIKMQFTISA PNSRPSTSSS FQANEDNIPV  60
   61 IAQKSTTIGG NVAANPPRFI SAKEHLRSYT YGGSTMGSSH PITLKNTSDL RST

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.442 0.831 meiotic chromosome segregation b.1.1 Immunoglobulin

Predicted Domain #7
Region A:
Residues: [1270-1373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QELNNLRMTY ERLRELSLNL GNRMVPPVGN FMPDSILKKM AAILPMNDSA FATLGTVEDK  60
   61 YRRRFKYFKA TIADLSKKRS SEDHEKYDTI LNDEFVNRAA ASSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 405.440336
Match: 1d8bA_
Description: HRDC domain from RecQ helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1374-1447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIAQSTGTKS KFFGANLNEA KENEQIINQI RQSQLPKNTT SSKSGTRSIS KSSKKSANGR  60
   61 RGFRNYRGHY RGRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle