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Protein Overview: ILV1

General Information:
Name(s) found: ILV1 / YER086W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 576 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: branched chain family amino acid biosynthetic process [TASLink to PubMed article]
    Molecular Function: L-threonine ammonia-lyase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATLLKQPL CTVVRQGKQS KVSGLNLLRL KAHLHRQHLS PSLIKLHSEL KLDELQTDNT  60
   61 PDYVRLVLRS SVYDVINESP ISQGVGLSSR LNTNVILKRE DLLPVFSFKL RGAYNMIAKL 120
  121 DDSQRNQGVI ACSAGNHAQG VAFAAKHLKI PATIVMPVCT PSIKYQNVSR LGSQVVLYGN 180
  181 DFDEAKAECA KLAEERGLTN IPPFDHPYVI AGQGTVAMEI LRQVRTANKI GAVFVPVGGG 240
  241 GLIAGIGAYL KRVAPHIKII GVETYDAATL HNSLQRNQRT PLPVVGTFAD GTSVRMIGEE 300
  301 TFRVAQQVVD EVVLVNTDEI CAAVKDIFED TRSIVEPSGA LSVAGMKKYI STVHPEIDHT 360
  361 KNTYVPILSG ANMNFDRLRF VSERAVLGEG KEVFMLVTLP DVPGAFKKMQ KIIHPRSVTE 420
  421 FSYRYNEHRH ESSSEVPKAY IYTSFSVVDR EKEIKQVMQQ LNALGFEAVD ISDNELAKSH 480
  481 GRYLVGGASK VPNERIISFE FPERPGALTR FLGGLSDSWN LTLFHYRNHG ADIGKVLAGI 540
  541 SVPPRENLTF QKFLEDLGYT YHDETDNTVY QKFLKY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CLU1 EFT2, EFT1 GCN20 GUS1 ILV1 RPN2 TUB3 YHR020W
    View Details Krogan NJ, et al. (2006) ILV1 ILV5
    View Details Gavin AC, et al. (2006) DPS1 ILV1 PSA1 RPL18A, RPL18B
    View Details Gavin AC, et al. (2002) ACC1 ARO1 CAM1 CCT8 CLU1 COP1 CPA2 EFB1 FAP1 FDH1 GCN20 GFA1 GLO3 GPT2 GUS1 HSC82 IDH2 ILV1 KAP123 LYS12 MGA2 MKT1 MRPL3 NEW1 OLA1 PFK1 PGK1 PSA1 RAD51 RAD52 RET2 RET3 RFA1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPN9 RPT3 RPT5 RPT6 RVB2 SAM1 SBP1 SCJ1 SEC21 SEC26 SEC27 SEC28 SEH1 SMC3 TCB1 TEF1, TEF2 TEF4 TIF1, TIF2 TOS1 TSA1 TUB3 URA7 VAS1 YHB1 YOL098C
    View Details Qiu et al. (2008) ILV1 ILV3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ILV1 Huh WK, et al. (2003)
    View Data ILV1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77]
    [103..212]    		 PSI-BLAST 1441.0 Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain
    2 View Details [78..102]
    [213..386]    		 PSI-BLAST 1441.0 Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain
    3 View Details [387..576] PSI-BLAST 1441.0 Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  6.50887202511626 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  5.28856942236052 bayes_pls_golite062009
  • threonine racemase activity
    		•  4.44340924206787 bayes_pls_golite062009
  • threonine synthase activity
    		•  3.59927532963055 bayes_pls_golite062009
  • cysteine synthase activity
    		•  3.57860549303214 bayes_pls_golite062009
  • L-threonine ammonia-lyase activity
    		•  3.33109959091277 bayes_pls_golite062009
  • tryptophan synthase activity
    		•  1.99526226543975 bayes_pls_golite062009
  • lyase activity
    		•  1.87743897464083 bayes_pls_golite062009
  • binding
    		•  1.14906798355281 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.923824749425553 bayes_pls_golite062009
  • catalytic activity
    		•  0.645256181736122 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.476674617721478 bayes_pls_golite062009
  • protein binding
    		•  0.341967829237094 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  0.249761226675912 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.248470717905239 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle