YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Catalysis of the reaction: 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3. Catalysis of the reaction: L-ornithine = L-proline + NH3. Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3. Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + SO4(2-) (sulfate). Catalysis of the reaction: L-aspartate = fumarate + NH3. Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3. Catalysis of the reaction: L-histidine = urocanate + NH3. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Catalysis of the reaction: D-serine = pyruvate + NH3. Catalysis of the reaction: L-serine = pyruvate + NH3. Catalysis of the reaction: ethanolamine = acetaldehyde + NH3. Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3. Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid. Catalysis of the reaction: threo-3-hydroxy-L-aspartate = oxaloacetate + NH3. Catalysis of the reaction: L-threo-3-methylaspartate = mesaconate + NH3. Catalysis of the reaction: L-3-aminobutyryl-CoA = NH3 + crotonyl-CoA. Catalysis of the reaction: O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2. Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3. Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ammonia-lyase activity
Acc: GO:0016841
Aspect: Molecular Function
Desc: Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 100 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016841 - ammonia-lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle