Protein Overview: CDC55

General Information:
Name(s) found:	CDC55 / YGL190C [SGD]
Description(s) found: Found 34 descriptions. SHOW ALL	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip [SGD]
Organism:	Saccharomyces cerevisiae
Length:	526 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cellular bud tip [IDA] cellular bud neck [IDA] protein phosphatase type 2A complex [TAS]
Biological Process:	mitotic cell cycle spindle assembly checkpoint [IMP] negative regulation of exit from mitosis [IMP] protein amino acid dephosphorylation [TAS] pseudohyphal growth [IMP] actin filament organization [TAS] budding cell bud growth [TAS] translation [IMP]
Molecular Function:	protein serine/threonine phosphatase activity [IPI] protein phosphatase type 2A regulator activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQNNFDFKF SQCFGDKADI VVTEADLITA VEFDYTGNYL ATGDKGGRVV LFERSNSRHC  60
   61 EYKFLTEFQS HDAEFDYLKS LEIEEKINEI KWLRPTQRSH FLLSTNDKTI KLWKVYEKNI 120
  121 KLVSQNNLTE GVTFAKKGKP DNHNSRGGSV RAVLSLQSLK LPQLSQHDKI IAATPKRIYS 180
  181 NAHTYHINSI SLNSDQETFL SADDLRINLW NLDIPDQSFN IVDIKPTNME ELTEVITSAE 240
  241 FHPQECNLFM YSSSKGTIKL CDMRQNSLCD NKTKTFEEYL DPINHNFFTE ITSSISDIKF 300
  301 SPNGRYIASR DYLTVKIWDV NMDNKPLKTI NIHEQLKERL SDTYENDAIF DKFEVNFSGD 360
  361 SSSVMTGSYN NNFMIYPNVV TSGDNDNGIV KTFDEHNAPN SNSNKNIHNS IQNKDSSSSG 420
  421 NSHKRRSNGR NTGMVGSSNS SRSSIAGGEG ANSEDSGTEM NEIVLQADKT AFRNKRYGSL 480
  481 AQRSARNKDW GDDIDFKKNI LHFSWHPREN SIAVAATNNL FIFSAL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CDC55 PPH21 PPH22 RRD2 RTS1 TPD3 ZDS1 ZDS2
View Details	Krogan NJ, et al. (2006)		CDC55 FIR1 PHR1 PPH21 PPH22 RRD2 TPD3 YRR1 ZDS1 ZDS2
View Details	Gavin AC, et al. (2006)		CDC55 IML1 RTS3 TPD3 ZDS1 ZDS2
View Details	Gavin AC, et al. (2002)		BDF2 BLM10 CDC55 CIN1 CKB1 DYN1 ECM5 ERG13 GLY1 GUS1 HAT1 HAT2 HHF1, HHF2 HIF1 HOS2 HOS4 HSM3 ICL1 IML1 KAP123 KAP95 KEL1 KRE33 LIP2 LTE1 MAC1 MDN1 MIS1 MSB1 MYO5 NIP1 NMD5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRO1 PRT1 PSD2 PSE1 PSH1 PUP1 PUP2 PUP3 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RRD2 RSC3 RTS1 RTS3 SAM1 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TEL1 TPD3 TSC11 USO1 UTP20 VTH2 YBL104C YFR006W YOR1 YPR077C YRA1 ZDS1 ZDS2
View Details	Ho Y, et al. (2002)		ATG18 ATG2 CCT2 CCT3 CCT5 CCT6 CDC55 GPG1 HTA2 MKT1 PPE1 PPH21 PPH22 RPA135 RPB11 RTS1 RTS3 RVB1 SAP155 TAP42 TCP1 TPD3 YCK2 YHR033W
View Details	Qiu et al. (2008)		CDC55 PPH22 RTS1 RTS3 TPD3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CNS1	CDC55	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CDC55	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..419]	PSI-BLAST	64.0	beta1-subunit of the signal-transducing G protein heterotrimer
2	View Details	[420..526]	PSI-BLAST	24.0	Groucho/tle1, C-terminal domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2