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Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly). A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. Any process that modulates the rate, frequency, or extent of the signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly). A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition. Any process that increases the rate, frequency, or extent of the signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly). A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: mitotic cell cycle spindle assembly checkpoint
Acc: GO:0007094
Aspect: Biological Process
Desc: A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).
Synonyms:
  • Mad2-dependent checkpoint
  • negative regulation of mitotic metaphase/anaphase transition by spindle assembly checkpoint
Proteins in PDR annotated with:
   This term: 93 [Search]
   Term or descendants: 93 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007094 - mitotic cell cycle spindle assembly checkpoint (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle