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Protein Overview: CDC13

General Information:
Name(s) found: CDC13 / YDL220C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 924 amino acids

    Gene Ontology:
    Cellular Component: nuclear telomere cap complex [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    telomere capping [TASLink to PubMed article]
    Molecular Function: telomeric DNA binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTLEEPECP PHKNRIFVSS SKDFEGYPSK AIVPVQFVAL LTSIHLTETK CLLGFSNFER  60
   61 RGDQSQEDQY LIKLKFKDRG SERLARITIS LLCQYFDIEL PDLDSDSGAS PTVILRDIHL 120
  121 ERLCFSSCKA LYVSKHGNYT LFLEDIKPLD LVSVISTIST KSTNSSKHSS SELISECDLN 180
  181 NSLVDIFNNL IEMNRDEKNR FKFVKLIHYD IELKKFVQDQ QKVLSQKSKA AAINPFFVPN 240
  241 RLGIPYIESQ NEFNSQLMTL NVDEPTTDIS NMGEEMHDSA DPIEDSDSST TSSTGKYFSS 300
  301 KSYIQSQTPE RKTSVPNNWH DDDSGSKRKR KLSFHSPNAS SIRKAISYEQ LSLASVGSVE 360
  361 RLEGKIVGMN PPQFASINEF KYCTLKLYFT QLLPNVPDKV LVPGVNCIEI VIPTRERICE 420
  421 LFGVLNCQSD KISDILLLEK PDRISVEVER ILWDNDKTAS PGMAVWSLKN ISTDTQAQAQ 480
  481 VQVPAQSSAS IDPSRTRMSK MARKDPTIEF CQLGLDTFET KYITMFGMLV SCSFDKPAFI 540
  541 SFVFSDFTKN DIVQNYLYDR YLIDYENKLE LNEGFKAIMY KNQFETFDSK LRKIFNNGLR 600
  601 DLQNGRDENL SQYGIVCKMN IKVKMYNGKL NAIVRECEPV PHSQISSIAS PSQCEHLRLF 660
  661 YQRAFKRIGE SAISRYFEEY RRFFPIHRNG SHLAKLRFDE VKHEPKKSPT TPALAEHIPD 720
  721 LNADVSSFDV KFTDISSLLD SSARLPRPQQ THKSNTLYSC EGRIIAIEYH ASDLCFHITN 780
  781 ELPLLQTRGL APERVLQLHI ITSKNFAYFF NRSSAYLQRQ PLEEKYTQLA QFLGHSFKFN 840
  841 ITSSLTLFPD TTVALQIWCP IECTFRELQQ QLAHPKVAAA PDSGSLDCAI NATVNPLRLL 900
  901 AAQNGVTVKK EEDNDDDAGA VPTS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BUD4 CDC13 CDC15 GIR2 PRS5 RBG2 YIL152W
    View Details Ho Y, et al. (2002) ADH4 ASF1 BAT1 CDC13 CPR1 ECM10 EDE1 KAP95 PTC2 RAD53 SRP1 SWI4 TBF1 UTP22 YTA7
    View Details Qiu et al. (2008) CDC13 RAP1 RIF1 RIF2 STN1 TBF1 TEN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC13 STN1 2 Uetz P, et al. (2000)
    View Screen CDC13 SCS2 2 Unpublished Fields Lab Data
    View Screen CDC13 GIS3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..490] deduced N/A No confident structure predictions are available.
    2 View Details [491..641] PSI-BLAST 1276.0 CDC13 ssDNA-binding domain
    3 View Details [642..744] PSI-BLAST 1276.0 CDC13 ssDNA-binding domain
    4 View Details [745..924] deduced N/A No confident structure predictions are available.
    5 View Details [706..924] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • telomerase inhibitor activity
    		•  8.08322438894165 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  7.13197590913268 bayes_pls_golite062009
  • telomeric DNA binding
    		•  7.07761964836826 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.99127970564994 bayes_pls_golite062009
  • DNA binding
    		•  3.53568546959418 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.06066809614422 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.0183551365402 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  2.8741276864403 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.13063800565247 bayes_pls_golite062009
  • structural molecule activity
    		•  1.9177190829469 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.84350127337404 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.12203697857261 bayes_pls_golite062009
  • transcription factor activity
    		•  0.952569279670437 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.85691075793641 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.638831894247026 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.62994126331969 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • translation regulator activity
    		•  0.515576958825022 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.491028860958185 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.468402630523277 bayes_pls_golite062009
  • exonuclease activity
    		•  0.28313884527829 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.2080607201312 bayes_pls_golite062009
  • protein binding
    		•  0.152645195799531 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.10868826895563 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.10868826895563 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.0179535526984695 bayes_pls_golite062009
  • helicase activity
    		•  0.0121541775159524 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle