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Protein Overview: Dsor1-PA

General Information:
Name(s) found: Dsor1-PA / FBpp0071248 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • The gene Downstream of raf1 is referred to in FlyBase by the symbol Dmel\Dsor1 (CG15793, FBgn0010269). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9141828..9144070. It has the cytological map location 8D2-8D3. Based on sequence similarity, it is predicted to have molecular function</span>: MAP kinase kinase activity. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration; hemocyte differentiation; signal transduction. 32 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; organ system; egg; adult segment; chorion; adult mesothoracic segment; thoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 396 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: torso signaling pathway [NAS]
    MAPKKK cascade [NAS]
    anterior/posterior axis specification, embryo [TAS]
    signal transduction [IGI][IMP]
    epidermal growth factor receptor signaling pathway [NAS]
    regulation of Toll signaling pathway [NAS]
    sevenless signaling pathway [NAS]
    hemocyte differentiation [IGI]
    border follicle cell migration [IGI]
    protein amino acid phosphorylation [IEA][NAS][TAS]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    MAP kinase kinase activity [ISS][NAS][TAS]
    MAP kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNKLNLVL PPVNTEATVA AATVAPTPPF KTPSGTDTHS LLGKPKTSID ALTETLEGLD  60
   61 MGDTERKRIK MFLSQKEKIG ELSDEDLEKL GELGSGNGGV VMKVRHTHTH LIMARKLIHL 120
  121 EVKPAIKKQI LRELKVLHEC NFPHIVGFYG AFYSDGEISI CMEYMDGGSL DLILKRAGRI 180
  181 PESILGRITL AVLKGLSYLR DNHAIIHRDV KPSNILVNSS GEIKICDFGV SGQLIDSMAN 240
  241 SFVGTRSYMS PERLQGTHYS VQSDIWSLGL SLVEMAIGMY PIPPPNTATL ESIFADNAEE 300
  301 SGQPTDEPRA MAIFELLDYI VNEPPPKLEH KIFSTEFKDF VDICLKKQPD ERADLKTLLS 360
  361 HPWIRKAELE EVDISGWVCK TMDLPPSTPK RNTSPN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..396] PSI-BLAST 64.0 X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetylcholine receptor activator activity
    		•  5.9159846946654 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • transferase activity
    		•  2.34875558765742 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.94085498993561 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • MAP kinase 2 activity
    		•  1.93464174962664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.74206248731815 bayes_pls_golite062009
  • PTB domain binding
    		•  1.69692410125184 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.34841233233438 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.33825339298024 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.28428643482914 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.2266791546014 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.21636393741109 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.19908793854422 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.16995153203536 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • histone kinase activity (H3-S10 specific)
    		•  1.14432210832726 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.11664317075762 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.1007076636085 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  1.08910497299188 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.00828610859671 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • receptor binding
    		•  0.990272341309676 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.728507215600658 bayes_pls_golite062009
  • growth factor activity
    		•  0.707777793848936 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • peptidase activity
    		•  0.620684651690244 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • telethonin binding
    		•  0.564849360244591 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.537170519944039 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.442502307901785 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.425716341891679 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.344522125452779 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • heparin binding
    		•  0.199071129344272 bayes_pls_golite062009
  • collagen binding
    		•  0.154361871307716 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.0887520303124476 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  0.0794053647730006 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  0.0364367558658403 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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