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Protein Overview: TGFB1_RAT

General Information:
Name(s) found: TGFB1_RAT [Swiss-Prot]
Description(s) found:
Found 25 descriptions.
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  • Transforming growth factor beta-1 OS=Rattus norvegicus GN=Tgfb1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 390 amino acids

    Gene Ontology:
    Cellular Component: platelet alpha granule lumen [UNKNOWN]
    nucleus [UNKNOWN][IEA]
    extracellular space [IDA]
    cytoplasm [UNKNOWN][IDA]
    secretory granule [IDA]
    extracellular matrix [UNKNOWN]
    neuronal cell body [IDA]
    extracellular region [UNKNOWN][IEA]
    Golgi lumen [UNKNOWN]
    proteinaceous extracellular matrix [UNKNOWN][IEA]
    axon [IDA]
    cell surface [IDA]
    Biological Process: embryonic development [IEP]
    frontal suture morphogenesis [IEP]
    regulation of branching involved in mammary gland duct morphogenesis [UNKNOWN][IEA]
    endoderm development [UNKNOWN][IEA]
    negative regulation of cell-cell adhesion [UNKNOWN][IEA]
    response to progesterone stimulus [UNKNOWN][IEA]
    response to radiation [IEP]
    positive regulation of NF-kappaB transcription factor activity [IDA]
    hemopoietic progenitor cell differentiation [UNKNOWN]
    inflammatory response [UNKNOWN][IEA]
    response to hypoxia [IEP]
    tolerance induction to self antigen [UNKNOWN][IEA]
    negative regulation of neuroblast proliferation [IDA]
    cell death [UNKNOWN][IEA]
    positive regulation of collagen biosynthetic process [UNKNOWN][IEA]
    positive regulation of gene-specific transcription [UNKNOWN]
    negative regulation of cell growth [UNKNOWN][IEA]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    positive regulation of protein secretion [UNKNOWN][IEA]
    positive regulation of epithelial cell proliferation [IDA]
    positive regulation of peptidyl-serine phosphorylation [UNKNOWN][IEA]
    response to cholesterol [UNKNOWN][IEA]
    regulation of protein import into nucleus [UNKNOWN][IEA]
    response to organic substance [IDA]
    branch elongation involved in mammary gland duct branching [UNKNOWN][IEA]
    negative regulation of mitotic cell cycle [UNKNOWN][IEA]
    germ cell migration [UNKNOWN][IEA]
    response to organic cyclic substance [IEP]
    protein export from nucleus [UNKNOWN][IEA]
    positive regulation of branching involved in ureteric bud morphogenesis [IMP]
    response to laminar fluid shear stress [IEP]
    regulation of cell growth [TAS]
    negative regulation of transcription [UNKNOWN][IEA]
    cellular response to growth factor stimulus [UNKNOWN]
    negative regulation of epithelial cell proliferation [UNKNOWN][IDA]
    regulation of binding [UNKNOWN]
    epithelial to mesenchymal transition [IDA]
    positive regulation of protein amino acid dephosphorylation [UNKNOWN][IEA]
    organ regeneration [IMP]
    positive regulation of protein kinase B signaling cascade [UNKNOWN][IEA]
    cell proliferation [UNKNOWN]
    positive regulation of cellular protein metabolic process [UNKNOWN][IEA]
    positive regulation of MAP kinase activity [UNKNOWN][IEA]
    positive regulation of histone deacetylation [UNKNOWN][IEA]
    negative regulation of cell proliferation [UNKNOWN]
    positive regulation of cell proliferation [UNKNOWN]
    chondrocyte differentiation [UNKNOWN]
    negative regulation of cell cycle [UNKNOWN]
    positive regulation of transcription [UNKNOWN]
    myelination [IMP]
    lymph node development [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    pathway-restricted SMAD protein phosphorylation [UNKNOWN]
    morphogenesis of a branching structure [IDA]
    positive regulation of cell division [IEA]
    myeloid dendritic cell differentiation [UNKNOWN][IEA]
    G1/S transition checkpoint [UNKNOWN][IEA]
    positive regulation of SMAD protein nuclear translocation [UNKNOWN][IEA]
    response to protein stimulus [UNKNOWN][IEA]
    mononuclear cell proliferation [UNKNOWN][IEA]
    negative regulation of blood vessel endothelial cell migration [UNKNOWN][IEA]
    negative regulation of release of sequestered calcium ion into cytosol [IDA]
    phosphate metabolic process [UNKNOWN][IEA]
    positive regulation of blood vessel endothelial cell migration [UNKNOWN][IEA]
    ossification involved in bone remodeling [UNKNOWN][IEA]
    defense response to fungus, incompatible interaction [IDA]
    mammary gland development [UNKNOWN][IEA]
    ureteric bud development [UNKNOWN][IEA]
    negative regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    positive regulation of smooth muscle cell differentiation [IDA]
    positive regulation of protein amino acid phosphorylation [UNKNOWN]
    positive regulation of peptidyl-threonine phosphorylation [UNKNOWN][IEA]
    negative regulation of T cell activation [UNKNOWN]
    cellular response to dexamethasone stimulus [IDA]
    positive regulation of fibroblast migration [UNKNOWN][IEA]
    cell cycle arrest [UNKNOWN][IEA]
    inner ear development [IEP]
    epidermal growth factor receptor signaling pathway [UNKNOWN][IEA]
    transforming growth factor beta receptor signaling pathway [UNKNOWN]
    T cell homeostasis [UNKNOWN][IEA]
    response to glucose stimulus [IEP]
    receptor catabolic process [UNKNOWN][IEA]
    wound healing [IEP][IMP]
    induction of apoptosis [UNKNOWN][IEA]
    gut development [IEP]
    evasion of host defenses by virus [UNKNOWN][IEA]
    positive regulation of bone mineralization [UNKNOWN][IEA]
    SMAD protein complex assembly [UNKNOWN][IEA]
    SMAD protein nuclear translocation [UNKNOWN][IDA]
    positive regulation of phosphoinositide 3-kinase activity [UNKNOWN][IEA]
    negative regulation of DNA replication [UNKNOWN][IEA]
    cell-cell junction organization [UNKNOWN][IEA]
    T cell differentiation [UNKNOWN]
    positive regulation of isotype switching to IgA isotypes [UNKNOWN][IEA]
    positive regulation of gene expression [UNKNOWN]
    regulatory T cell differentiation [UNKNOWN][IEA]
    response to estradiol stimulus [UNKNOWN][IEP]
    regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    regulation of striated muscle tissue development [UNKNOWN][IEA]
    positive regulation of chemotaxis [UNKNOWN][IEA]
    positive regulation of pathway-restricted SMAD protein phosphorylation [UNKNOWN][IEA]
    negative regulation of phagocytosis [IDA]
    positive regulation of histone acetylation [UNKNOWN][IEA]
    response to vitamin D [IEP]
    response to wounding [UNKNOWN]
    T cell activation [UNKNOWN]
    protein amino acid phosphorylation [UNKNOWN]
    salivary gland morphogenesis [UNKNOWN][IEA]
    mammary gland branching involved in thelarche [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    positive regulation of epithelial to mesenchymal transition [UNKNOWN][IEA]
    positive regulation of exit from mitosis [IDA]
    regulation of DNA binding [UNKNOWN][IEA]
    positive regulation of odontogenesis [UNKNOWN]
    positive regulation of interleukin-17 production [UNKNOWN][IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    negative regulation of immune response [IDA]
    lens fiber cell differentiation [UNKNOWN][IEA]
    lung development [TAS]
    negative regulation of fat cell differentiation [UNKNOWN]
    female pregnancy [IEP]
    ATP biosynthetic process [UNKNOWN][IEA]
    aging [IEP]
    regulation of cell proliferation [UNKNOWN][TAS]
    cellular calcium ion homeostasis [UNKNOWN][IEA]
    regulation of sodium ion transport [UNKNOWN]
    negative regulation of T cell proliferation [UNKNOWN][IEA]
    response to drug [IEP]
    positive regulation of apoptosis [IDA][IMP]
    negative regulation of ossification [UNKNOWN][IEA]
    Molecular Function: growth factor activity [IEA]
    protein binding [UNKNOWN]
    protein homodimerization activity [IDA]
    transforming growth factor beta receptor binding [IC][TAS]
    protein heterodimerization activity [IDA]
    protein N-terminus binding [IMP]
    transcription activator activity [UNKNOWN][IEA]
    type II transforming growth factor beta receptor binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSGLRLLP LLLPLPWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA  60
   61 SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESADPEPEPE ADYYAKEVTR VLMVDRNNAI 120
  121 YDKTKDITHS IYMFFNTSDI REAVPEPPLL SRAELRLQRF KSTVEQHVEL YQKYSNNSWR 180
  181 YLGNRLLTPT DTPEWLSFDV TGVVRQWLNQ GDGIQGFRFS AHCSCDSKDN VLHVEINGIS 240
  241 PKRRGDLGTI HDMNRPFLLL MATPLERAQH LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI 300
  301 DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SASPCCVPQA 360
  361 LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle