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Any process that modulates the rate or extent of progress through the mitotic cell cycle. The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle. Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle. Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that modulates the rate or extent of progression through the cell cycle. Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of mitotic cell cycle
Acc: GO:0045930
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
Synonyms:
  • inhibition of progression through mitotic cell cycle
  • down regulation of progression through mitotic cell cycle
  • down-regulation of progression through mitotic cell cycle
  • downregulation of progression through mitotic cell cycle
  • negative regulation of progression through mitotic cell cycle
  • negative regulation of mitotic cell cycle progression
Proteins in PDR annotated with:
   This term: 45 [Search]
   Term or descendants: 68 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045930 - negative regulation of mitotic cell cycle (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle