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The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. Any process that stops, prevents or reduces the frequency, rate or extent of bone formation. Any process that modulates the frequency, rate or extent of bone formation. Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of ossification
Acc: GO:0030279
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of bone formation.
Synonyms:
  • downregulation of ossification
  • down-regulation of ossification
  • negative regulation of bone biosynthesis
  • down regulation of ossification
  • inhibition of ossification
  • negative regulation of bone formation
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 30 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030279 - negative regulation of ossification (interactive image map)
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Created and Maintained by: Michael Riffle