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Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis. Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. The process by which a protein is incorporated into a mitochondrial membrane as an early step in apoptosis. A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. Any process that modulates the occurrence or rate of cell death by apoptosis. A process that directly activates any of the steps required for cell death by apoptosis. A process which directly activates any of the steps required for programmed cell death. Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: induction of apoptosis
Acc: GO:0006917
Aspect: Biological Process
Desc: A process that directly activates any of the steps required for cell death by apoptosis.
Synonyms:
  • apoptosis signaling
  • commitment to apoptosis
  • induction of apoptosis by p53
  • apoptosis activator activity
  • activation of apoptosis
Proteins in PDR annotated with:
   This term: 268 [Search]
   Term or descendants: 552 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006917 - induction of apoptosis (interactive image map)

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