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The directed movement of calcium ions (Ca2+) into the cytosol. The process by which calcium ions sequestered in the endoplasmic reticulum or mitochondria are released into the cytosolic compartment. Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells by means of some external agent such as a transporter or pore. Any process that stops, prevents or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. Any process that stops, prevents or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of release of sequestered calcium ion into cytosol
Acc: GO:0051280
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
Synonyms:
  • negative regulation of calcium ion (Ca2+) mobilization
  • negative regulation of cytosolic release of sequestered calcium ion (Ca2+)
  • negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)
  • down regulation of release of sequestered calcium ion into cytosol
  • negative regulation of calcium mobilization
  • negative regulation of release of stored calcium ion (Ca2+) into cytoplasm
  • negative regulation of release of stored calcium ion (Ca2+) into cytosol
  • downregulation of release of sequestered calcium ion into cytosol
  • down-regulation of release of sequestered calcium ion into cytosol
  • negative regulation of cytoplasmic release of stored calcium ion (Ca2+)
  • inhibition of release of sequestered calcium ion into cytosol
  • negative regulation of cytosolic release of stored calcium ion (Ca2+)
  • negative regulation of release of sequestered calcium ion into cytoplasm
  • negative regulation of release of stored calcium ion (Ca2+)
  • negative regulation of release of sequestered calcium ion (Ca2+)
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051280 - negative regulation of release of sequestered calcium ion into cytosol (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle