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Protein Overview: PDR12

General Information:
Name(s) found: PDR12 / YPL058C [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1511 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: organic acid transport [IDALink to PubMed article]
    propionate metabolic process [IEPLink to PubMed article]
    transport [TASLink to PubMed article]
    Molecular Function: organic acid transmembrane transporter activity [IDALink to PubMed article]
    xenobiotic-transporting ATPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTDEHIEK DISSRSNHDD DYANSVQSYA ASEGQVDNED LAATSQLSRH LSNILSNEEG  60
   61 IERLESMARV ISHKTKKEMD SFEINDLDFD LRSLLHYLRS RQLEQGIEPG DSGIAFKNLT 120
  121 AVGVDASAAY GPSVEEMFRN IASIPAHLIS KFTKKSDVPL RNIIQNCTGV VESGEMLFVV 180
  181 GRPGAGCSTF LKCLSGETSE LVDVQGEFSY DGLDQSEMMS KYKGYVIYCP ELDFHFPKIT 240
  241 VKETIDFALK CKTPRVRIDK MTRKQYVDNI RDMWCTVFGL RHTYATKVGN DFVRGVSGGE 300
  301 RKRVSLVEAQ AMNASIYSWD NATRGLDAST ALEFAQAIRT ATNMVNNSAI VAIYQAGENI 360
  361 YELFDKTTVL YNGRQIYFGP ADKAVGYFQR MGWVKPNRMT SAEFLTSVTV DFENRTLDIK 420
  421 PGYEDKVPKS SSEFEEYWLN SEDYQELLRT YDDYQSRHPV NETRDRLDVA KKQRLQQGQR 480
  481 ENSQYVVNYW TQVYYCMIRG FQRVKGDSTY TKVYLSSFLI KALIIGSMFH KIDDKSQSTT 540
  541 AGAYSRGGML FYVLLFASVT SLAEIGNSFS SRPVIVKHKS YSMYHLSAES LQEIITEFPT 600
  601 KFVAIVILCL ITYWIPFMKY EAGAFFQYIL YLLTVQQCTS FIFKFVATMS KSGVDAHAVG 660
  661 GLWVLMLCVY AGFVLPIGEM HHWIRWLHFI NPLTYAFESL VSTEFHHREM LCSALVPSGP 720
  721 GYEGISIANQ VCDAAGAVKG NLYVSGDSYI LHQYHFAYKH AWRNWGVNIV WTFGYIVFNV 780
  781 ILSEYLKPVE GGGDLLLYKR GHMPELGTEN ADARTASREE MMEALNGPNV DLEKVIAEKD 840
  841 VFTWNHLDYT IPYDGATRKL LSDVFGYVKP GKMTALMGES GAGKTTLLNV LAQRINMGVI 900
  901 TGDMLVNAKP LPASFNRSCG YVAQADNHMA ELSVRESLRF AAELRQQSSV PLEEKYEYVE 960
  961 KIITLLGMQN YAEALVGKTG RGLNVEQRKK LSIGVELVAK PSLLLFLDEP TSGLDSQSAW1020
 1021 SIVQFMRALA DSGQSILCTI HQPSATLFEQ FDRLLLLKKG GKMVYFGDIG PNSETLLKYF1080
 1081 ERQSGMKCGV SENPAEYILN CIGAGATASV NSDWHDLWLA SPECAAARAE VEELHRTLPG1140
 1141 RAVNDDPELA TRFAASYMTQ IKCVLRRTAL QFWRSPVYIR AKFFECVACA LFVGLSYVGV1200
 1201 NHSVGGAIEA FSSIFMLLLI ALAMINQLHV FAYDSRELYE VREAASNTFH WSVLLLCHAA1260
 1261 VENFWSTLCQ FMCFICYYWP AQFSGRASHA GFFFFFYVLI FPLYFVTYGL WILYMSPDVP1320
 1321 SASMINSNLF AAMLLFCGIL QPREKMPAFW RRLMYNVSPF TYVVQALVTP LVHNKKVVCN1380
 1381 PHEYNIMDPP SGKTCGEFLS TYMDNNTGYL VNPTATENCQ YCPYTVQDQV VAKYNVKWDH1440
 1441 RWRNFGFMWA YICFNIAAML ICYYVVRVKV WSLKSVLNFK KWFNGPRKER HEKDTNIFQT1500
 1501 VPGDENKITK K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PDR12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..421] PSI-BLAST 122.38764 Peptide transporter Tap1, C-terminal ABC domain
    3 View Details [422..838] deduced N/A No confident structure predictions are available.
    4 View Details [839..866]
    [888..916]    		 PSI-BLAST 156.154902 Haemolysin B ATP-binding protein
    5 View Details [867..887]
    [917..1091]    		 PSI-BLAST 156.154902 Haemolysin B ATP-binding protein
    6 View Details [1092..1389] MSA 23.864961 View MSA. No confident structure predictions are available.
    7 View Details [1390..1511] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • lipid transporter activity
    		•  7.47642599298853 bayes_pls_golite062009
  • lipopolysaccharide transmembrane transporter activity
    		•  5.90177503313326 bayes_pls_golite062009
  • lipopolysaccharide-transporting ATPase activity
    		•  5.90177503313326 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • polysaccharide transmembrane transporter activity
    		•  5.26442752745523 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • sterol transporter activity
    		•  4.45355165759136 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • hydrolase activity
    		•  3.14498892233323 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00745742755195 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  2.88795687640992 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  2.72457626066894 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • eye pigment precursor transporter activity
    		•  2.19742277986318 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  2.12727614888121 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  1.95782378818812 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  1.88153949603611 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • fluconazole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • azole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • binding
    		•  1.64266915208623 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • signal recognition particle binding
    		•  1.23869719200594 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • potassium channel activity
    		•  1.17288958041707 bayes_pls_golite062009
  • GTPase activity
    		•  1.16964908174651 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.896078342024449 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • phospholipid transporter activity
    		•  0.755445322666929 bayes_pls_golite062009
  • motor activity
    		•  0.677658554107 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.62832939629645 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • DNA binding
    		•  0.361518668029935 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  0.301752323171649 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.169034229773346 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • signal transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.133605084599819 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.11674780318211 bayes_pls_golite062009
  • protein transporter activity
    		•  0.104820191623932 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.050232896280066 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.0181245554613096 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle