Protein Overview: DCS2

General Information:
Name(s) found:	DCS2 / YOR173W [SGD]
Description(s) found: Found 16 descriptions. SHOW ALL	Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p. [SGD]
Organism:	Saccharomyces cerevisiae
Length:	397 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] cytoplasmic mRNA processing body [IDA]
Biological Process:	deadenylation-dependent decapping of nuclear-transcribed mRNA [IDA]
Molecular Function:	m7G(5')pppN diphosphatase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIKAERRET EARGFRLVFK YMLGRYLFIA KLKRFERVKV KKYMMGSQDL ASLIGRFKYV  60
   61 RVLDSNPHTK VISLLGSIDG KDAVLTAEKT HFIFDETVRR PSQSGRSTPI FFHREIDEYS 120
  121 FLNGITDLKE LTSNDIYYWG LSVLKQHILH NPTAKVNLIW PASQFHIKGY DQQDLHVVRE 180
  181 TPDMYRNIVV PFIQEMCTSE RMKWVNNILY EGAEDDRVVY KEYSSRNKED GFVILPDMKW 240
  241 DGINIDSLYL VAIVYRDDIK SLRDLNPNHR DWLIRLNKKI KTIIPQHYDY NVNPDELRVF 300
  301 IHYQPSYYHF HVHIVNIRHP GVGEERGSGM TILLEDVIEA LGFLGPEGYM KKTLTYVIGE 360
  361 NHDLWKKGFK EEVEKQLKHD GIATSPEKGS GFNTNLG

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		DCS1 DCS2
View Details	Krogan NJ, et al. (2006)		DCS1 DCS2 YPL245W
View Details	Gavin AC, et al. (2006)		DCS2 TFB3
View Details	Gavin AC, et al. (2002)		CCL1 DCS2 FAP1 FPR1 KAP95 KIN28 MRPS28 SPT7 SSL1 TFA1 TFB1 TFB3 TFB4 TIF6
View Details	Ho Y, et al. (2002)		AHP1 CDC39 DCS1 DCS2 GDB1 RAD50 TSA2 UBP15 UBR1 VPS1 YAK1 YLR241W YPL247C
View Details	Qiu et al. (2008)		DCP1 DCP2 DCS1 DCS2 LSM1 RPB4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RGD2	DCS2	1	Unpublished Fields Lab Data
View Screen	YHR122W	DCS2	1	Hazbun TR, et al. (2003)
View Screen	UBC12	DCS2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..397]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
m7G(5')pppN diphosphatase activity	11.4290795741181	bayes_pls_golite062009
RNA binding	2.65561768780165	bayes_pls_golite062009
nucleic acid binding	1.24536295645879	bayes_pls_golite062009
binding	1.12315862086587	bayes_pls_golite062009
hydrolase activity	0.927269748430359	bayes_pls_golite062009
catalytic activity	0.096119422680995	bayes_pls_golite062009
protein binding	0.0635855651106229	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2