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Protein Overview: PFY1

General Information:
Name(s) found: PFY1 / YOR122C [SGD]
Description(s) found:
Found 41 descriptions.
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  • Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 126 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck contractile ring [IDALink to PubMed article]
    actin cap [IPILink to PubMed article]
    Biological Process: axial cellular bud site selection [IMPLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    actin polymerization or depolymerization [TASLink to PubMed article]
    actin nucleation [TASLink to PubMed article]
    intracellular transport [IGILink to PubMed article]
    response to osmotic stress [IMPLink to PubMed article]
    Molecular Function: actin monomer binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWQAYTDNL IGTGKVDKAV IYSRAGDAVW ATSGGLSLQP NEIGEIVQGF DNPAGLQSNG  60
   61 LHIQGQKFML LRADDRSIYG RHDAEGVVCV RTKQTVIIAH YPPTVQAGEA TKIVEQLADY 120
  121 LIGVQY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Qiu et al. (2008) ABP1 ABP140 ACT1 AIP1 ARC15 ARC40 ARP2 BBC1 BEM1 BNI1 BNR1 BOI1 BUD4 BUD6 CAP1 CAP2 CDC10 CDC3 COF1 CRN1 END3 ENT3 GIC1 GIC2 HOF1 IQG1 LAS17 MLC1 MLC2 MYO4 PAN1 PEA2 PFY1 RVS161 RVS167 SAC6 SCP1 SLA1 SLA2 SLG1 SRV2 TPM1 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PFY1 ACT1 2 Drees BL, et al. (2001)
    View Screen PFY1 BNR1 2 Drees BL, et al. (2001)
    View Screen PFY1 SRV2 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PFY1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 700.522879 Profilin (actin-binding protein)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.981958446142 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.51470611165788 bayes_pls_golite062009
  • actin monomer binding
    		•  3.80837480536839 bayes_pls_golite062009
  • binding
    		•  3.26636517628678 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  3.24248939295046 bayes_pls_golite062009
  • protein binding
    		•  2.14534188091242 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.69872978885701 bayes_pls_golite062009
  • phospholipid binding
    		•  1.52027694872856 bayes_pls_golite062009
  • transporter activity
    		•  1.434681455285 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.23300160340736 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.490905558612378 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle