Protein Overview: CAF40

General Information:
Name(s) found:	CAF40 / YNL288W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324041\|ref\|NP_014111.1\| Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p; Caf40p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S63262 hypothetical protein YNL288w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730650\|sp\|P53829.1\|CAF40_YEAST RecName: Full=Protein CAF40; AltName: Full=40 kDa CCR4-associated factor [NCBI NR] gi\|1302371\|emb\|CAA96205.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P53829) Hypothetical 41.2 kDa protein in PLC1-SEC21 intergenic region [Swiss-Prot] Protein CAF40 OS=Saccharomyces cerevisiae GN=CAF40 PE=1 SV=1 [Swiss-Prot] CAF40 CCR4 Associated Factor 40 kDa [mips] Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p [SGD] Chr XIV from 90301-91422 [yeastorf3.fasta] CAF40, Chr XIV from 90301-91422 [yeast_orfs2] CAF40 SGDID:S0005232, Chr XIV from 90301-91422, Verified ORF [yeastflysequest.fasta] CCR4 Associated Factor 40 kDa [Saccharomyces cerevisiae]gi\|1302371\|emb\|CAA96205.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1730650\|sp\|P53829\|YN28_YEAST Hypothetical 41.2 kDa protein in PLC1-SEC21 intergenic regiongi\|2131957\|pir\|\|S63262 hyp [nrdb_11152004_Chlamydomonas] CAF40 SGDID:S000005232, Chr XIV from 90303-91424, Verified ORF, "Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Protein CAF40 (40 kDa CCR4-associated factor) [nr-271106-contam.fasta] Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p; Caf40p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Protein CAF40 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAF40 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CAF40 SGDID:S000005232, Chr XIV from 90303-91424, Genome Release 64-1-1, Verified ORF, "Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p" [yeast-030211-contam.fasta] CAF40 SGDID:S000005232, Chr XIV from 90303-91424, Genome Release 64-2-1, Verified ORF, "Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p" [20141208_orf_trans.fasta] YNL288W SGDID:S000005232, Chr XIV from 90303-91424, Genome Release 64-1-1, Verified ORF, "Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	373 amino acids
Gene Ontology:
Cellular Component:	CCR4-NOT complex [IPI]
Biological Process:	regulation of transcription from RNA polymerase II promoter [IPI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG GPMLMGNTPN  60
   61 NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA LDDPNVYHWI CQLTYGPQKE 120
  121 QALLELGRKR EQFDDLAVVL WSSFGVMTSL LNEIISVYPM LQPQMLSNNL SNRVCNALVL 180
  181 LQCVASHPET KHLFLQAHIP LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT 240
  241 FLLRTDIVPL CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM 300
  301 VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV LRDDVGSKRC 360
  361 LAQLLLTLNE ETS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CAF130 CAF40 CCR4 CDC39 POP2
View Details	Krogan NJ, et al. (2006)		CAF40 CCR4 CDC39 POP2
View Details	Gavin AC, et al. (2006)		CAF40 CCR4 CDC39 POP2
View Details	Gavin AC, et al. (2002)		AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TFC7 TFP1 YRA1
View Details	Qiu et al. (2008)		CAF16 CAF4 CAF40 CCR4 CDC36 CDC39 MOT2 NOT3 NOT5 POP2 SUS1 TFB5

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	CAF40	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..76]	deduced	N/A	No confident structure predictions are available.
2	View Details	[77..279]	ab initio	8.35	No description for 1ee5A was found.
3	View Details	[280..373]	ab initio	8.35	No description for 1ee5A was found.

Protein Overview: CAF40

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: