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Protein Overview: YCK2

General Information:
Name(s) found: YCK2 / YNL154C [SGD]
Description(s) found:
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  • gi|6324175|ref|NP_014245.1| Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p; [NCBI NR]
  • gi|433622|emb|CAA42896.1| casein kinase-1 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S29522 casein kinase I homolog YCK2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|173210|gb|AAA35230.1| casein kinase I [NCBI NR]
  • gi|140437|sp|P23292.1|KC12_YEAST RecName: Full=Casein kinase I homolog 2 [NCBI NR]
  • gi|1302114|emb|CAA96041.1| YCK2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1050798|emb|CAA63285.1| YCK2 [Saccharomyces cerevisiae] [NCBI NR]
  • Casein kinase I homolog 2 OS=Saccharomyces cerevisiae GN=YCK2 PE=1 SV=1 [Swiss-Prot]
  • (P23292) Casein kinase I homolog 2 (EC 2.7.1.-) [Swiss-Prot]
  • YCK2 Casein kinase I isoform [mips]
  • Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p [SGD]
  • YCK2, Chr XIV from 343633-345273, reverse complement [yeast_orfs2]
  • Chr XIV from 343633-345273, reverse complement [yeastorf3.fasta]
  • Chr XIV from 345273-343633, reverse complement [yeastorf5.fasta]
  • YCK2 SGDID:S0005098, Chr XIV from 345276-343636, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Yck2p [Saccharomyces cerevisiae]gi|433622|emb|CAA42896.1| casein kinase-1 [Saccharomyces cerevisiae]gi|1050798|emb|CAA63285.1| YCK2 [Saccharomyces cerevisiae]gi|1302114|emb|CAA96041.1| YCK2 [Saccharomyces cerevisiae]gi|320648|pir||S29522 casein kinase [nrdb_11152004_Chlamydomonas]
  • YCK2 SGDID:S000005098, Chr XIV from 345278-343638, reverse complement, Verified ORF, "Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; prov [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YCK2 SGDID:S000005098, Chr XIV from 345278-343638, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provi [yeast-200209-contam.fasta]
  • casein kinase I [nr-271106-contam.fasta]
  • YCK2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • casein kinase-1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Casein kinase I homolog 2 [nr-271106-contam.fasta]
  • Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p; Yck2p [Saccharomyces cerevi [nr-271106-contam.fasta]
  • YCK2 SGDID:S000005098, Chr XIV from 345278-343638, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p" [yeast-bovrabprots.fasta]
  • YCK2 SGDID:S000005098, Chr XIV from 345278-343638, reverse complement, Verified ORF, "Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Casein kinase I homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YCK2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • YCK2 SGDID:S000005098, Chr XIV from 345276-343636, Genome Release 64-1-1, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p" [yeast-030211-contam.fasta]
  • YCK2 SGDID:S000005098, Chr XIV from 345276-343636, Genome Release 64-2-1, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; YCK2 has a paralog, YCK1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL154C SGDID:S000005098, Chr XIV from 345276-343636, Genome Release 64-1-1, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed article]
    mating projection [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: response to glucose stimulus [IMPLink to PubMed article]
    cell morphogenesis [IGILink to PubMed articleLink to PubMed article]
    cytokinesis [IGILink to PubMed articleLink to PubMed article]
    protein amino acid phosphorylation [IMPLink to PubMed article][ISSLink to PubMed article]
    endocytosis [IGILink to PubMed article]
    Molecular Function: casein kinase I activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVQSPLTA TNSGLAVNNN TMNSQMPNRS NVRLVNGTLP PSLHVSSNLN HNTGNSSASY  60
   61 SGSQSRDDST IVGLHYKIGK KIGEGSFGVL FEGTNMINGL PVAIKFEPRK TEAPQLKDEY 120
  121 RTYKILAGTP GIPQEYYFGQ EGLHNILVID LLGPSLEDLF DWCGRRFSVK TVVQVAVQMI 180
  181 TLIEDLHAHD LIYRDIKPDN FLIGRPGQPD ANKVHLIDFG MAKQYRDPKT KQHIPYREKK 240
  241 SLSGTARYMS INTHLGREQS RRDDMEAMGH VFFYFLRGQL PWQGLKAPNN KQKYEKIGEK 300
  301 KRLTNVYDLA QGLPIQFGRY LEIVRNLSFE ETPDYEGYRM LLLSVLDDLG ETADGQYDWM 360
  361 KLNGGRGWDL SINKKPNLHG YGHPNPPNEK SKRHRSKNHQ YSSPDHHHHY NQQQQQQQAQ 420
  421 AQAQAQAQAK VQQQQLQQAQ AQQQANRYQL QPDDSHYDEE REASKLDPTS YEAYQQQTQQ 480
  481 KYAQQQQKQM QQKSKQFANT GANGQTNKYP YNAQPTANDE QNAKNAAQDR NSNKSSKGFF 540
  541 SKLGCC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP16 FIT1 YCK1 YCK2 YMR118C
    View Details (MIPS) Mewes HW, et al. (2004) HRR25 YCK1 YCK2 YCK3
    View Details Ho Y, et al. (2002) BCY1 CAR2 CDC55 CYS4 GND1 GTO1 LAA1 LYS1 PDC5 PPH21 PPH22 SAH1 SNO2 SSN8 THI21 THI22 THO2 TIF1, TIF2 TPD3 TPK2 TPK3 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPT53
    View Details Qiu et al. (2008) HRR25 YCK1 YCK2 YCK3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YCK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118]
    [135..150]    		 PSI-BLAST 1294.0 Casein kinase-1, CK1
    2 View Details [119..134]
    [151..156]
    [181..233]    		 PSI-BLAST 1294.0 Casein kinase-1, CK1
    3 View Details [157..180]
    [234..384]    		 PSI-BLAST 1294.0 Casein kinase-1, CK1
    4 View Details [385..546] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16307073947901 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06086848160606 bayes_pls_golite062009
  • DNA binding
    		•  1.02122968429273 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • transcription factor activity
    		•  0.825932471558326 bayes_pls_golite062009
  • peptidase activity
    		•  0.540289770145252 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.265003282584135 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.205652638854091 bayes_pls_golite062009
  • receptor binding
    		•  0.197402253061255 bayes_pls_golite062009
  • actin filament binding
    		•  0.10870608219756 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle