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View Structure Prediction Details

Protein: YCK2
Organism: Saccharomyces cerevisiae
Length: 546 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YCK2.

Description E-value Query
Range		 Subject
Range
YCK2 - Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p i...
KC12_YEAST - Casein kinase I homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YCK2 PE=1 SV=1
 0.0 [1..546] [1..546]
KC1D_ARATH - Casein kinase I isoform delta-like OS=Arabidopsis thaliana GN=At4g26100 PE=2 SV=2
 0.0 [69..529] [2..444]
gi|5162880, gi|5... - gi|5162880|dbj|BAA81750.1| calcium-dependent protein kinase [Marchantia polymorpha], gi|5162877|dbj|...
 0.0 [14..424] [7..421]
gi|4336426 - gi|4336426|gb|AAD17800.1| Ca2+-dependent protein kinase [Mesembryanthemum crystallinum]
 0.0 [4..423] [7..424]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..424] [65..493]

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Predicted Domain #1
Region A:
Residues: [1-118] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVQSPLTA TNSGLAVNNN TMNSQMPNRS NVRLVNGTLP PSLHVSSNLN HNTGNSSASY  60
   61 SGSQSRDDST IVGLHYKIGK KIGEGSFGVL FEGTNMINGL PVAIKFEPRK TEAPQLKD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [135-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYYFGQEGLH NILVID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1294.0
Match: 1csn__
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription regulator activity 1.16307073947901 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
nucleic acid binding 1.06086848160606 bayes_pls_golite062009
DNA binding 1.02122968429273 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
transcription factor activity 0.825932471558326 bayes_pls_golite062009
peptidase activity 0.540289770145252 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.265003282584135 bayes_pls_golite062009
MAP kinase activity 0.26024936404169 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
actin filament binding 0.10870608219756 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [119-134] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYRTYKILAG TPGIPQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [151-156] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLGPSL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [181-233] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLIEDLHAHD LIYRDIKPDN FLIGRPGQPD ANKVHLIDFG MAKQYRDPKT KQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1294.0
Match: 1csn__
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [157-180] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDLFDWCGRR FSVKTVVQVA VQMI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [234-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPYREKKSLS GTARYMSINT HLGREQSRRD DMEAMGHVFF YFLRGQLPWQ GLKAPNNKQK  60
   61 YEKIGEKKRL TNVYDLAQGL PIQFGRYLEI VRNLSFEETP DYEGYRMLLL SVLDDLGETA 120
  121 DGQYDWMKLN GGRGWDLSIN KKPNLHGYGH P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1294.0
Match: 1csn__
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [385-546] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPPNEKSKRH RSKNHQYSSP DHHHHYNQQQ QQQQAQAQAQ AQAQAKVQQQ QLQQAQAQQQ  60
   61 ANRYQLQPDD SHYDEEREAS KLDPTSYEAY QQQTQQKYAQ QQQKQMQQKS KQFANTGANG 120
  121 QTNKYPYNAQ PTANDEQNAK NAAQDRNSNK SSKGFFSKLG CC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle