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Protein Overview: RPL6A

General Information:
Name(s) found: RPL6A / YML073C [SGD]
Description(s) found:
Found 30 descriptions.
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  • N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 176 amino acids

    Gene Ontology:
    Cellular Component: ribonucleoprotein complex [IEA]
    cytoplasm [IEA]
    cytosolic large ribosomal subunit [IDA]
    ribosome [IEA]
    intracellular [IEA]
    Biological Process: ribosomal large subunit assembly [IMPLink to PubMed article]
    translation [IDA]
    Molecular Function: RNA binding [IDALink to PubMed article]
    structural constituent of ribosome [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK RVVYLKHLED  60
   61 NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK FNVEYFAKEK LTKKEKKEAN 120
  121 LFPEQQNKEI KAERVEDQKV VDKALIAEIK KTPLLKQYLS ASFSLKNGDK PHMLKF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN12 HCA4 HHO1 ISA2 KEM1 NHP6A NOG1 NOP12 NOP2 NOP58 PUF4 RPF2 RPL10 RPL11B RPL12B, RPL12A RPL13A RPL13B RPL15A RPL16A RPL16B RPL17A RPL17B RPL18A, RPL18B RPL1A, RPL1B RPL20A RPL20B RPL21A RPL24A RPL25 RPL28 RPL29 RPL2A, RPL2B RPL3 RPL30 RPL32 RPL33B RPL34A RPL36A RPL36B RPL42B, RPL42A RPL43B, RPL43A RPL4A RPL4B RPL6A RPL8A RPL8B RPL9A RPS11A, RPS11B RPS14A RPS16B, RPS16A RPS17B RPS18B, RPS18A RPS1A RPS1B RPS2 RPS22A RPS23B, RPS23A RPS26A RPS3 RPS30B, RPS30A RPS5 RPS6A, RPS6B RPS7A RPS8B, RPS8A RPS9B SBP1 YHI9
    View Details (MIPS) Mewes HW, et al. (2004) RPL10 RPL11A RPL11B RPL12B, RPL12A RPL13A RPL13B RPL14A RPL14B RPL15A RPL15B RPL16A RPL16B RPL17A RPL17B RPL18A, RPL18B RPL19B, RPL19A RPL1A, RPL1B RPL20A RPL20B RPL21A RPL21B RPL22A RPL22B RPL23B, RPL23A RPL24A RPL24B RPL25 RPL26A RPL26B RPL27A RPL27B RPL28 RPL29 RPL2A, RPL2B RPL3 RPL30 RPL31A RPL31B RPL32 RPL33A RPL33B RPL34A RPL34B RPL35A, RPL35B RPL36A RPL36B RPL37A RPL37B RPL38 RPL39 RPL40B, RPL40A RPL41A, RPL41B RPL42B, RPL42A RPL43B, RPL43A RPL4A RPL4B RPL5 RPL6A RPL6B RPL7A RPL7B RPL8A RPL8B RPL9A RPL9B RPP0 RPP1A RPP1B RPP2A RPP2B
    View Details Qiu et al. (2008) ASC1 ATG27 BUD20 EFT2, EFT1 HMS2 NAT3 RKI1 RPL10 RPL11A RPL11B RPL12B, RPL12A RPL13A RPL13B RPL14A RPL14B RPL15A RPL15B RPL16A RPL16B RPL17A RPL17B RPL18A, RPL18B RPL19B, RPL19A RPL1A, RPL1B RPL20A RPL20B RPL21A RPL21B RPL22A RPL22B RPL23B, RPL23A RPL24A RPL24B RPL25 RPL26A RPL26B RPL27A RPL27B RPL28 RPL29 RPL2A, RPL2B RPL3 RPL30 RPL31A RPL31B RPL32 RPL33A RPL33B RPL34A RPL34B RPL35A, RPL35B RPL36A RPL36B RPL37A RPL37B RPL38 RPL39 RPL40B, RPL40A RPL41A, RPL41B RPL42B, RPL42A RPL43B, RPL43A RPL4A RPL4B RPL5 RPL6A RPL6B RPL7A RPL7B RPL8A RPL8B RPL9A RPL9B RPP0 RPP1A RPP1B RPP2A RPP2B RPS0A RPS0B RPS10A RPS10B RPS11A, RPS11B RPS12 RPS13 RPS14A RPS14B RPS15 RPS16B, RPS16A RPS17A RPS17B RPS18B, RPS18A RPS19A RPS19B RPS1A RPS1B RPS2 RPS20 RPS21A RPS21B RPS22A RPS22B RPS23B, RPS23A RPS24A, RPS24B RPS25A RPS25B RPS26A RPS26B RPS27A RPS27B RPS28A RPS28B RPS29A RPS29B RPS3 RPS30B, RPS30A RPS31 RPS4B, RPS4A RPS5 RPS6A, RPS6B RPS7A RPS7B RPS8B, RPS8A RPS9A RPS9B SOP4 STM1 TEF1, TEF2 TIF5 TOS4 TSR1 VAR1 YML6 YPL199C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPL6A Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] MSA 4.033992 View MSA. No confident structure predictions are available.
    2 View Details [67..176] Pfam 70.657577 Ribosomal protein L6e No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of ribosome
    		•  9.33175622373475 bayes_pls_golite062009
  • structural molecule activity
    		•  8.78104488316498 bayes_pls_golite062009
  • binding
    		•  1.53082494948413 bayes_pls_golite062009
  • RNA binding
    		•  1.34286989242843 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.34250569976274 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.24801565562229 bayes_pls_golite062009
  • DNA binding
    		•  0.817602006068725 bayes_pls_golite062009
  • protein binding
    		•  0.431966441580751 bayes_pls_golite062009
  • transcription factor activity
    		•  0.151888933180377 bayes_pls_golite062009
  • translation regulator activity
    		•  0.084754562593104 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.0564075582229911 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle