Protein Overview: VPS71

General Information:
Name(s) found:	VPS71 / YML041C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|683666\|emb\|CAA88328.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323600\|ref\|NP_013671.1\| Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting; Vps71p [Saccharomyces cerevisiae] [NCBI NR] gi\|2497094\|sp\|Q03433.1\|VPS71_YEAST RecName: Full=Vacuolar protein sorting-associated protein 71; AltName: Full=SWR complex protein 6 [NCBI NR] pir\|\|S52479 hypothetical protein YML041c - yeast (Saccharomyces cerevisiae) [NCBI NR] (Q03433) Hypothetical 32.0 kDa protein in CAT2-AMD1 intergenic region [Swiss-Prot] Vacuolar protein sorting-associated protein 71 OS=Saccharomyces cerevisiae GN=VPS71 PE=1 SV=1 [Swiss-Prot] VPS71 Component of the Swr1p complex that incorporates Htz1p into chromatin, required for vacuolar protein sorting [mips] Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [SGD] YML041C, Chr XIII from 194913-195755, reverse complement [yeast_orfs2] Chr XIII from 194913-195755, reverse complement [yeastorf3.fasta] Chr XIII from 195755-194913, reverse complement [yeastorf5.fasta] VPS71 SGDID:S0004505, Chr XIII from 195755-194913, reverse complement, Verified ORF [yeastflysequest.fasta] Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for vacuolar protein sorting [Saccharomyces cerevisiae]gi\|683666\|emb\|CAA88328.1\| unknown [Saccharomyces cerevisiae]gi\|2497094\|sp\|Q03433\|YMEI_YEA [nrdb_11152004_Chlamydomonas] VPS71 SGDID:S000004505, Chr XIII from 195755-194913, reverse complement, Verified ORF, "Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for vacuolar protein sorting" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] VPS71 SGDID:S000004505, Chr XIII from 195755-194913, reverse complement, Verified ORF, "nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" [yeast-contam.fasta] VPS71 SGDID:S000004505, Chr XIII from 195755-194913, reverse complement, Verified ORF, "Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Vacuolar protein sorting-associated protein 71 (SWR complex protein 6) [nr-271106-contam.fasta] nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting; Vps71p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Vacuolar protein sorting-associated protein 71 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS71 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] VPS71 SGDID:S000004505, Chr XIII from 195755-194913, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" [yeast-030211-contam.fasta] VPS71 SGDID:S000004505, Chr XIII from 195755-194913, Genome Release 64-2-1, reverse complement, Verified ORF, "Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" [20141208_orf_trans.fasta] TR3011\|c0_g1_i1\|g.2138 ORF TR3011\|c0_g1_i1\|g.2138 TR3011\|c0_g1_i1\|m.2138 type:complete len:281 (+) TR3011\|c0_g1_i1:401-1243(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YML041C SGDID:S000004505, Chr XIII from 195755-194913, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_4114\|g.2659 ORF ID=asmbl_4114\|g.2659 ID=asmbl_4114\|m.2659 type:complete len:281 (+) ID=asmbl_4114:419-1261(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	280 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] Swr1 complex [IDA ]
Biological Process:	chromatin remodeling [IDA][IGI][IMP] histone exchange [IMP] protein targeting to vacuole [IMP]
Molecular Function:	nucleosome binding [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKALVEEIDK KTYNPDIYFT SLDPQARRYT SKKINKQGTI STSRPVKRIN YSLADLEARL  60
   61 YTSRSEGDGN SISRQDDRNS KNSHSFEERY TQQEILQSDR RFMELNTENF SDLPNVPTLL 120
  121 SDLTGVPRDR IESTTKPISQ TSDGLSALMG GSSFVKEHSK YGHGWVLKPE TLREIQLSYK 180
  181 STKLPKPKRK NTNRIVALKK VLSSKRNLHS FLDSALLNLM DKNVIYHNVY NKRYFKVLPL 240
  241 ITTCSICGGY DSISSCVNCG NKICSVSCFK LHNETRCRNR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARP4 ARP6 RVB1 RVB2 SWC3 SWC5 SWR1 VPS71 VPS72
View Details	Krogan NJ, et al. (2006)		ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
View Details	Qiu et al. (2008)		ARP4 ARP6 SWC4 SWC5 VPS71 VPS72 YAF9

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SWI5	VPS71	1	Unpublished Fields Lab Data
View Screen	DOT1	VPS71	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	VPS71	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..182]	deduced	N/A	No confident structure predictions are available.
2	View Details	[183..280]	MSA	7.010997	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2