Protein Overview: LSM3

General Information:
Name(s) found:	LSM3 / YLR438C-A [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|S78568 snRNP protein SMX4 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6323471\|ref\|NP_013543.1\| Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, sno [NCBI NR] gi\|12230246\|sp\|P57743.1\|LSM3_YEAST RecName: Full=U6 snRNA-associated Sm-like protein LSm3; AltName: Full=SmX4 protein [NCBI NR] U6 snRNA-associated Sm-like protein LSm3 OS=Saccharomyces cerevisiae GN=LSM3 PE=1 SV=1 [Swiss-Prot] LSM3 Sm-like (Lsm) protein [mips] Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [SGD] LSM3, Chr XII from 1013904-1014173, reverse complement [yeast_orfs2] Chr XII from 1013904-1014173, reverse complement [yeastorf3.fasta] Chr XII from 1014173-1013904, reverse complement [yeastorf5.fasta] (P57743) U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein) [4932.FASTACCERV.txt] LSM3 SGDID:S0006434, Chr XII from 1014174-1013905, reverse complement, Verified ORF [yeastflysequest.fasta] Component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay [Saccharomyces cerevisiae]gi\|12230246\|sp\|P57743\|LSM3_YEAST U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein)gi\|7493897\|pir\|\|S78568 snRNP protein [nrdb_11152004_Chlamydomonas] LSM3 SGDID:S000006434, Chr XII from 1014174-1013905, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex pa [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] LSM3 SGDID:S000006434, Chr XII from 1014175-1013906, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex pa [yeast-contam.fasta] U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein) [nr-271106-contam.fasta] Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; Lsm3p [Saccha [nr-271106-contam.fasta] LSM3 SGDID:S000006434, Chr XII from 1014175-1013906, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" [yeast-bovrabprots.fasta] [chemostatdb.fasta] U6 snRNA-associated Sm-like protein LSm3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LSM3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] LSM3 SGDID:S000006434, Chr XII from 1014178-1013909, Genome Release 64-1-1, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" [yeast-030211-contam.fasta] LSM3 SGDID:S000006434, Chr XII from 1014178-1013909, Genome Release 64-2-1, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" [20141208_orf_trans.fasta] YLR438C-A SGDID:S000006434, Chr XII from 1014178-1013909, Genome Release 64-1-1, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	89 amino acids
Gene Ontology:
Cellular Component:	U4/U6 x U5 tri-snRNP complex [IDA][NAS] nucleolus [IDA] U6 snRNP [IDA ][TAS ] small nucleolar ribonucleoprotein complex [IPI]
Biological Process:	mRNA catabolic process [TAS] nuclear mRNA splicing, via spliceosome [IPI][TAS]
Molecular Function:	RNA binding [IPI][TAS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 METPLDLLKL NLDERVYIKL RGARTLVGTL QAFDSHCNIV LSDAVETIYQ LNNEELSESE 60 61 RRCEMVFIRG DTVTLISTPS EDDDGAVEI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		KEM1 LSM1 LSM3 LSM5 LSM6 PAT1
View Details	Krogan NJ, et al. (2006)		KEM1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PAT1 PRP24 YGR054W
View Details	Gavin AC, et al. (2002)		ASC1 CDC33 CLF1 CWC23 DCP2 DHH1 DIB1 ERB1 KRS1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 NAM7 NOG2 NOP1 NUG1 PAT1 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 SMB1 SMD2 SNU114 SNU23 SNU66 SPP382 SQS1 SRO9
View Details	Qiu et al. (2008)		AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 DIB1 HSH155 ISY1 LEA1 LSM2 LSM3 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 PRP16 PRP18 PRP19 PRP2 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD3 SME1 SMX2 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SPP2 SPP381 SPP382 SUB2 SYF2 YHC1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	LSM3	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89]	PSI-BLAST	88.533179	Archaeal homoheptameric Sm protein

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
	9.36615441177233	bayes_pls_golite062009
RNA binding	5.81718051012035	bayes_pls_golite062009
nucleic acid binding	2.69031444148163	bayes_pls_golite062009
mRNA binding	2.57166143288861	bayes_pls_golite062009
binding	2.04681172391952	bayes_pls_golite062009
protein binding	0.187097443004706	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle