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Protein Overview: VPS34

General Information:
Name(s) found: VPS34 / YLR240W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 875 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    Biological Process: vacuole inheritance [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    phosphoinositide phosphorylation [IDALink to PubMed article]
    vacuolar transport [IMPLink to PubMed article]
    inositol lipid-mediated signaling [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    protein targeting to vacuole [IDALink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]
    1-phosphatidylinositol-3-kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNNITFCV SQDLDVPLKV KIKSLEGHKP LLKPSQKILN PELMLIGSNV FPSSDLIVSL  60
   61 QVFDKERNRN LTLPIYTPYI PFRNSRTWDY WLTLPIRIKQ LTFSSHLRII LWEYNGSKQI 120
  121 PFFNLETSIF NLKDCTLKRG FESLKFRYDV IDHCEVVTDN KDQENLNKYF QGEFTRLPWL 180
  181 DEITISKLRK QRENRTWPQG TFVLNLEFPM LELPVVFIER EIMNTQMNIP TLKNNPGLST 240
  241 DLREPNRNDP QIKISLGDKY HSTLKFYDPD QPNNDPIEEK YRRLERASKN ANLDKQVKPD 300
  301 IKKRDYLNKI INYPPGTKLT AHEKGSIWKY RYYLMNNKKA LTKLLQSTNL REESERVEVL 360
  361 ELMDSWAEID IDDALELLGS TFKNLSVRSY AVNRLKKASD KELELYLLQL VEAVCFENLS 420
  421 TFSDKSNSEF TIVDAVSSQK LSGDSMLLST SHANQKLLKS ISSESETSGT ESLPIVISPL 480
  481 AEFLIRRALV NPRLGSFFYW YLKSESEDKP YLDQILSSFW SRLDKKSRNI LNDQVRLINV 540
  541 LRECCETIKR LKDTTAKKME LLVHLLETKV RPLVKVRPIA LPLDPDVLIC DVCPETSKVF 600
  601 KSSLSPLKIT FKTTLNQPYH LMFKVGDDLR QDQLVVQIIS LMNELLKNEN VDLKLTPYKI 660
  661 LATGPQEGAI EFIPNDTLAS ILSKYHGILG YLKLHYPDEN ATLGVQGWVL DNFVKSCAGY 720
  721 CVITYILGVG DRHLDNLLVT PDGHFFHADF GYILGQDPKP FPPLMKLPPQ IIEAFGGAES 780
  781 SNYDKFRSYC FVAYSILRRN AGLILNLFEL MKTSNIPDIR IDPNGAILRV RERFNLNMSE 840
  841 EDATVHFQNL INDSVNALLP IVIDHLHNLA QYWRT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) PAA1 PTC2 PTC3 PTC4 VPS34
    View Details Gavin AC, et al. (2006) VPS15 VPS30 VPS34 VPS38

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS34 Huh WK, et al. (2003)
    View Data VPS34 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..674]
    [798..830]    		 PSI-BLAST 666.228787 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    2 View Details [675..797]
    [831..875]    		 PSI-BLAST 666.228787 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • 1-phosphatidylinositol-3-kinase activity
    		•  8.12544462052019 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  8.10715314025226 bayes_pls_golite062009
  • lipid kinase activity
    		•  5.98454599133418 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  5.59422890717019 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    		•  4.51744163880238 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  2.37116581763683 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.36057410204148 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • profilin binding
    		•  2.1052288288978 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • signal transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.63027742934354 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.4515576307774 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • neurexin binding
    		•  1.37902741014529 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.27941426224024 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.27740808551012 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • receptor activity
    		•  1.13726344123824 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.96468055729151 bayes_pls_golite062009
  • phospholipase activity
    		•  0.689713182053935 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57867852584301 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • phospholipase C activity
    		•  0.526467636680161 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.5066845540941 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • SNARE binding
    		•  0.3731056408292 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • clathrin binding
    		•  0.35775052108553 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  0.302570916877053 bayes_pls_golite062009
  • protein complex binding
    		•  0.265979208658691 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.205652638854091 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.200784507667389 bayes_pls_golite062009
  • insulin binding
    		•  0.123049243480919 bayes_pls_golite062009
  • hydrolase activity
    		•  0.056449407710228 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.00492507437049428 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle