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View Structure Prediction Details

Protein: VPS34
Organism: Saccharomyces cerevisiae
Length: 875 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS34.

Description E-value Query
Range		 Subject
Range
VPS34_YEAST - Phosphatidylinositol 3-kinase VPS34 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS3...
gi|190405302 - gi|190405302|gb|EDV08569.1| phosphatidylinositol 3-kinase VPS34 [Saccharomyces cerevisiae RM11-1a]
VPS34 - Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; for...
gi|151941076 - gi|151941076|gb|EDN59456.1| phosphatidylinositol 3-kinase [Saccharomyces cerevisiae YJM789]
 0.0 [1..875] [1..875]
PK3C3_RAT - Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Rattus norvegicus GN=Pik3c3 PE=1 SV=1
 0.0 [3..874] [4..886]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..874] [4..886]
PI3K1_SOYBN - Phosphatidylinositol 3-kinase, root isoform OS=Glycine max PE=2 SV=1
 0.0 [1..874] [1..814]
gi|19353278 - gi|19353278|gb|AAH24675.1| Pik3c3 protein [Mus musculus]
 0.0 [3..830] [4..841]
PI3K_ARATH - Phosphatidylinositol 3-kinase VPS34 OS=Arabidopsis thaliana GN=At1g60490 PE=2 SV=2
 0.0 [1..874] [1..814]
Pi3K59F-PA - The gene Phosphotidylinositol 3 kinase 59F is referred to in FlyBase by the symbol Dmel\Pi3K59F (CG5...
gi|220945154 - gi|220945154|gb|ACL85120.1| Pi3K59F-PA [synthetic construct]
 0.0 [6..874] [8..948]

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Predicted Domain #1
Region A:
Residues: [1-674] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNNITFCV SQDLDVPLKV KIKSLEGHKP LLKPSQKILN PELMLIGSNV FPSSDLIVSL  60
   61 QVFDKERNRN LTLPIYTPYI PFRNSRTWDY WLTLPIRIKQ LTFSSHLRII LWEYNGSKQI 120
  121 PFFNLETSIF NLKDCTLKRG FESLKFRYDV IDHCEVVTDN KDQENLNKYF QGEFTRLPWL 180
  181 DEITISKLRK QRENRTWPQG TFVLNLEFPM LELPVVFIER EIMNTQMNIP TLKNNPGLST 240
  241 DLREPNRNDP QIKISLGDKY HSTLKFYDPD QPNNDPIEEK YRRLERASKN ANLDKQVKPD 300
  301 IKKRDYLNKI INYPPGTKLT AHEKGSIWKY RYYLMNNKKA LTKLLQSTNL REESERVEVL 360
  361 ELMDSWAEID IDDALELLGS TFKNLSVRSY AVNRLKKASD KELELYLLQL VEAVCFENLS 420
  421 TFSDKSNSEF TIVDAVSSQK LSGDSMLLST SHANQKLLKS ISSESETSGT ESLPIVISPL 480
  481 AEFLIRRALV NPRLGSFFYW YLKSESEDKP YLDQILSSFW SRLDKKSRNI LNDQVRLINV 540
  541 LRECCETIKR LKDTTAKKME LLVHLLETKV RPLVKVRPIA LPLDPDVLIC DVCPETSKVF 600
  601 KSSLSPLKIT FKTTLNQPYH LMFKVGDDLR QDQLVVQIIS LMNELLKNEN VDLKLTPYKI 660
  661 LATGPQEGAI EFIP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [798-830] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRNAGLILNL FELMKTSNIP DIRIDPNGAI LRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 666.228787
Match: 1e7uA_
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [675-797] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDTLASILSK YHGILGYLKL HYPDENATLG VQGWVLDNFV KSCAGYCVIT YILGVGDRHL  60
   61 DNLLVTPDGH FFHADFGYIL GQDPKPFPPL MKLPPQIIEA FGGAESSNYD KFRSYCFVAY 120
  121 SIL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [831-875] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RERFNLNMSE EDATVHFQNL INDSVNALLP IVIDHLHNLA QYWRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 666.228787
Match: 1e7uA_
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
1-phosphatidylinositol-3-kinase activity 8.12544462052019 bayes_pls_golite062009
phosphoinositide 3-kinase activity 8.10715314025226 bayes_pls_golite062009
lipid kinase activity 5.98454599133418 bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity 5.59422890717019 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
protein kinase activity 5.17195961442593 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 3-kinase activity 4.51744163880238 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
calcium-dependent phospholipid binding 2.37116581763683 bayes_pls_golite062009
protein tyrosine kinase activity 2.36057410204148 bayes_pls_golite062009
binding 2.31930216202447 bayes_pls_golite062009
profilin binding 2.1052288288978 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
molecular transducer activity 1.95775692939268 bayes_pls_golite062009
signal transducer activity 1.95775692939268 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
receptor signaling protein activity 1.63027742934354 bayes_pls_golite062009
protein transmembrane transporter activity 1.4515576307774 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
neurexin binding 1.37902741014529 bayes_pls_golite062009
transmembrane receptor activity 1.27941426224024 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.27740808551012 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
receptor activity 1.13726344123824 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.96468055729151 bayes_pls_golite062009
phospholipase activity 0.689713182053935 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.58590430118616 bayes_pls_golite062009
insulin receptor substrate binding 0.57867852584301 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
phospholipase C activity 0.526467636680161 bayes_pls_golite062009
MAP kinase activity 0.5066845540941 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
SNARE binding 0.3731056408292 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
clathrin binding 0.35775052108553 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
calcium-dependent protein binding 0.302570916877053 bayes_pls_golite062009
protein complex binding 0.265979208658691 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
nuclear localization sequence binding 0.200784507667389 bayes_pls_golite062009
insulin binding 0.123049243480919 bayes_pls_golite062009
hydrolase activity 0.056449407710228 bayes_pls_golite062009
primary active transmembrane transporter activity 0.00492507437049428 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle