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Protein Overview: Pi3K59F-PA

General Information:
Name(s) found: Pi3K59F-PA / FBpp0071973 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Phosphotidylinositol 3 kinase 59F is referred to in FlyBase by the symbol Dmel\Pi3K59F (CG5373, FBgn0015277). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19448017..19451570. It has the cytological map location 59E4-59F1. There is experimental evidence that it has the molecular function</span>: 1-phosphatidylinositol-3-kinase activity. There is experimental evidence that it is involved in the biological process</span>: dsRNA transport; phosphoinositide phosphorylation. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 949 amino acids

    Gene Ontology:
    Cellular Component: phosphoinositide 3-kinase complex [IEA]
    phosphoinositide 3-kinase complex, class III [NAS]
    Biological Process: phosphoinositide-mediated signaling [IEA]
    phosphoinositide phosphorylation [IDA][ISS][NAS]
    dsRNA transport [IMP]
    Molecular Function: [NOT]phosphatidylinositol-4,5-bisphosphate 3-kinase activity [IDA]
    phosphoinositide 3-kinase activity [NAS]
    binding [IEA]
    [NOT]phosphatidylinositol-4-phosphate 3-kinase activity [IDA]
    1-phosphatidylinositol-3-kinase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQPDDHFRY IHSSSLHERV QIKVGTLEGK KRQPDYEKLL EDPILRFSGL YSEEHPSFQV  60
   61 RLQVFNQGRP YCLPVTSSYK AFGKRWSWNE WVTLPLQFSD LPRSAMLVLT ILDCSGAGQT 120
  121 TVIGGTSISM FGKDGMFRQG MYDLRVWLGV EGDGNFPSRT PGKGKESSKS QMQRLGKLAK 180
  181 KHRNGQVQKV DWLDRLTFRE IEVINEREKR MSDYMFLMIE FPAIVVDDMY NYAVVYFEPE 240
  241 GDVKYKLPAK PKLVSVPDSE IQMENLVERK HHRLARSERS GISDRDAKPT ASIRDQLHTI 300
  301 VYRYPPTYVL SSEEQDLVWK FRFYLSSHKK ALTKFLKCIN WKLEDEVTQA LWMLANWAPM 360
  361 DVEDALELLS PTFTHPQVRK YAVSRLAQAP DEDLLLYLLQ LVQALKYEDP RHIVHLHGCI 420
  421 FPERDVVRSI LDDNGSLLDQ SSLSDLSATS SGLHGSVIPA NQRAASVLAA IKSDKSVSPG 480
  481 SAGGSGSGGQ GSVALPNPSA PATPGSSSLP CDSNSNALML AEGISFGSVP ANLCTFLIQR 540
  541 ACTNATLANY FYWYLSIEVE EVESVRKQDE RAHDMYAMVL KMFLKVLENG NFNLRGIFYN 600
  601 LRKQRRFIDE LVKLVKLVAK EPGNRNKKTE KFQKLLAEQD MFKVNFTNFE PIPFPLDPEI 660
  661 YITKIVPMRT SLFKSALMPA KLTFVTSIAH HEYAAIFKHG DDLRQDQLIL QMITLMDKLL 720
  721 RRENLDLKLT PYKVLATSSK HGFLQYVDSC TVAEVLAREG NIHNFFRKHH PCDNGPYGIS 780
  781 AEVMDTYIKS CAGYCVITYL LGVGDRHLDN LLLTTNGKLF HIDFGYILGR DPKPMPPPMK 840
  841 LSKEMVEAMG GISSEHHHEF RKQCYTAYLH LRRHANVMLN LFSLMVDATV PDIALEPDKA 900
  901 VKKVEENLQL GLTDEEAVQH LQSLLDVSIT AVMPALVEQI HRFTQYWRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] FFAS03 1.37 No description for 2uzpA was found.
    2 View Details [154..250] MSA 1.055995 View MSA. No confident structure predictions are available.
    3 View Details [251..949] PSI-BLAST 115.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • 1-phosphatidylinositol-3-kinase activity
    		•  8.12544462052019 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  8.10715314025226 bayes_pls_golite062009
  • lipid kinase activity
    		•  5.98454599133418 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  5.59422890717019 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    		•  4.51744163880238 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • signal transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.02389895825558 bayes_pls_golite062009
  • profilin binding
    		•  0.982035967740892 bayes_pls_golite062009
  • phospholipase activity
    		•  0.689713182053935 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.5066845540941 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal sequence binding
    		•  0.14931345687137 bayes_pls_golite062009
  • phospholipase C activity
    		•  0.105085008317406 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle