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Protein Overview: MSC3

General Information:
Name(s) found: MSC3 / YLR219W [SGD]
Description(s) found:
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  • gi|74644915|sp|Q05812.1|MSC3_YEAST RecName: Full=Meiotic sister-chromatid recombination protein 3 [NCBI NR]
  • gi|6323248|ref|NP_013320.1| Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substr [NCBI NR]
  • pir||S48569 hypothetical protein YLR219w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|544498|gb|AAB67423.1| Ylr219wp [Saccharomyces cerevisiae] [NCBI NR]
  • Meiotic sister-chromatid recombination protein 3 OS=Saccharomyces cerevisiae GN=MSC3 PE=1 SV=1 [Swiss-Prot]
  • MSC3 Protein involved meiotic recombination events to homologous chromatids [mips]
  • Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate [SGD]
  • MSC3, Chr XII from 574151-576337 [yeast_orfs2]
  • Chr XII from 574151-576337 [yeastorf3.fasta]
  • >Q05812 (Q05812) Chromosome XII COSMID 8167 (YLR219WP) [4932.FASTACCERV.txt]
  • MSC3 SGDID:S0004209, Chr XII from 574153-576339, Verified ORF [yeastflysequest.fasta]
  • Msc3p [Saccharomyces cerevisiae]gi|626441|pir||S48569 hypothetical protein YLR219w - yeast (Saccharomyces cerevisiae)gi|544498|gb|AAB67423.1| Ylr219wp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • (Q05812) Ylr219wp [cerv4932.FASTAC]
  • MSC3 SGDID:S000004209, Chr XII from 574153-576339, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; Msc3p [Saccharomyces ce [nr-271106-contam.fasta]
  • Ylr219wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Meiotic sister-chromatid recombination protein 3 [nr-271106-contam.fasta]
  • MSC3 SGDID:S000004209, Chr XII from 574153-576339, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Meiotic sister-chromatid recombination protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSC3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MSC3 SGDID:S000004209, Chr XII from 574151-576337, Genome Release 64-1-1, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate" [yeast-030211-contam.fasta]
  • MSC3 SGDID:S000004209, Chr XII from 574151-576337, Genome Release 64-2-1, Verified ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YLR219W SGDID:S000004209, Chr XII from 574151-576337, Genome Release 64-1-1, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 728 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: reciprocal meiotic recombination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFGFTKRDR RVPDLSRYDY YYQNHEDYNK SPQLSAAAAS AASAASPDRT NYSRSHSLVS  60
   61 HAPSIPRQRS SVKSPGRRLS TSSAAPPTSR AAAKQYSQKT YSLRSQRSGE YHLHPPGYTT 120
  121 NGSRMNSMTS GANVRRNYGK NKSTAGNNND SRANSITVKT TQVTDPSGRT QSITKKTIRK 180
  181 INGYEYVETT TTTKNLVPLG DSQRHFDEFS ENYMLQDDDI LEEQASDNIH DIIEENETDN 240
  241 EKPYSPVSES HLQDDSELNV EKPDFPLGSY FHHKYSTDVM PLEEESSLSN FSDALDYIPP 300
  301 THQTSSKYIH NKRKQASTTR RKKRPPAVKN AEAEAKKPLT EAEMYLKALE VAKRNVYHTD 360
  361 AASDNASAPL GSNKSRKSRM GQKMTLRSSS DSPTATANLV KSNVEVQPKR FTSSFFSRNT 420
  421 KSAPHEVHNH SVSTHFKSNK AVDPVPEPKS ANTGLTDKEM YDQALKIAQA RYYNSHGIQP 480
  481 EAVDNSTTAA KPRQVGVSHL GSTGSIPPNE QHYLGDSEIP VQSEVHEYEP IPLQKTKTTG 540
  541 SSKNKFKTMF DKVLQFSQEN YGYQHKKEQG EQTPVTRNAE ESFPAASISE GVTTAKPSSN 600
  601 EGVMTNPVVT DSPSPLQQQI DSTTASSNGQ SQGNVPTSAV ASTTRTRSPE LQDNLKSSSS 660
  661 LLQDQTPQRQ EDATDPTTSS TNELSAAEPT MVTSTHATKT IQAQTQDPPT KHKKSSFFTK 720
  721 LFKKKSSR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W
    View Details Ho Y, et al. (2002) AIM46 ARE1 CDC33 FET4 FUN12 GRS1 HAS1 IMD2 IMD3 IMD4 KRE33 KRI1 MAG2 MGM101 MSC3 NOC2 NOP12 NOP4 NPL3 OYE2 PDC6 RPF2 RRP12 TIF4631 TIF4632 UTP22

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MSC3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] ORFEUS 11.14 Fibrinogen
    2 View Details [167..525] ORFEUS 10.93 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    3 View Details [526..665] ORFEUS 10.93 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    4 View Details [666..728] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [689..728] MSA 1.002996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle