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Protein Overview: SIR1

General Information:
Name(s) found: SIR1 / YKR101W [SGD]
Description(s) found:
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  • gi|6322954|ref|NP_013027.1| Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric ch [NCBI NR]
  • gi|486607|emb|CAA82181.1| SIR1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|172606|gb|AAA35046.1| silent information regulator [Saccharomyces cerevisiae] [NCBI NR]
  • gi|134505|sp|P21691.1|SIR1_YEAST RecName: Full=Regulatory protein SIR1; AltName: Full=Silent information regulator 1 [NCBI NR]
  • pir||S14173 SIR1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Regulatory protein SIR1 OS=Saccharomyces cerevisiae GN=SIR1 PE=1 SV=1 [Swiss-Prot]
  • SIR1 Silencing regulatory protein [mips]
  • Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin [SGD]
  • SIR1, Chr XI from 640097-642133 [yeast_orfs2]
  • Chr XI from 640097-642133 [yeastorf3.fasta]
  • (P21691) Regulatory protein SIR1 (Silent information regulator 1) [4932.FASTACCERV.txt]
  • SIR1 SGDID:S0001809, Chr XI from 640104-642140, Verified ORF [yeastflysequest.fasta]
  • SIR1 SGDID:S0001809, Chr XI from 640106-642142, Verified ORF [10112005cervSGD.fasta]
  • Sir1p [Saccharomyces cerevisiae]gi|486607|emb|CAA82181.1| SIR1 [Saccharomyces cerevisiae]gi|101621|pir||S14173 SIR1 protein - yeast (Saccharomyces cerevisiae)gi|134505|sp|P21691|SIR1_YEAST Regulatory protein SIR1 (Silent information regulator 1)gi|172 [nrdb_11152004_Chlamydomonas]
  • SIR1 SGDID:S000001809, Chr XI from 640106-642142, Verified ORF, "Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • silent information regulator [nr-271106-contam.fasta]
  • SIR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Regulatory protein SIR1 (Silent information regulator 1) [nr-271106-contam.fasta]
  • Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin; Sir1p [Saccharomyce [nr-271106-contam.fasta]
  • SIR1 SGDID:S000001809, Chr XI from 640106-642142, Verified ORF, "Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 678 amino acids

    Gene Ontology:
    Cellular Component: chromatin silencing complex [IDALink to PubMed article]
    Biological Process: establishment of chromatin silencing [IMPLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IGILink to PubMed article]
    Molecular Function: DNA binding [TASLink to PubMed article]
    chromatin binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTIMSIITR RYKQLKNYKI ISKKMLQINS RLAVIDGWLV DTVKRKPINF RSPEVRLLLP  60
   61 NDDDYKKLSQ QNLVDWTRLK KDSNSVLVGV KSMELFKHIK LVLREFFLLE DGRIILKRIR 120
  121 SKLRYKVVKK LTCKCCRLYL PKWGTVYIHP MLKDKEKPLA GVCEFSLDVN PDREYPLIEI 180
  181 NVSHQYIIIE GFLLYLNERR LYRWNDNNLR SQVGLTKWAH LRKTYNPVSL DILYSLNSNF 240
  241 YFVKDDLLFQ LLGKRVFVKF CKVMENGKCG KAPLWYRVKR TTTAKATHIA YAISNSTAPD 300
  301 SFKSKNNDYR FIVREKPIVE NTISNLDYSD IKKQQFTEAE VVKRKISADI SQIENVHTQF 360
  361 NSQKEKNNIR VNKVSSEVLD QISKFPVSRV TLLLMSAGQD KNYIELVEEL ARRLEKICIE 420
  421 KTTQSLEEIR DTFQANPEMQ ASFDKEYYQS IEEYKITLEL IKEDLLITLI KQMENMWAAE 480
  481 KKFSTEEEYV SPRFLVADGF LIDLAEEKPI NPKDPRLLTL LKDHQRAMID QMNLVKWNDF 540
  541 KKYQDPIPLK AKTLFKFCKQ IKKKFLRGAD FKLHTLPTEA NLKYEPERMT VLCSCVPILL 600
  601 DDQTVQYLYD DSIIPEFEAT SSYATKQSKC GRKMSLQMEP DLLFQEAIRR MRHLTAYDVL 660
  661 RRNYIAAFEE LYMGNCND

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C
    View Details Ho Y, et al. (2002) ADH6 COR1 CYS4 GAS1 ILV5 RNR2 SAH1 SES1 SIR1 SIR3 TEF4 TMA29

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen APC5 SIR1 1 Unpublished Fields Lab Data
    View Screen GPA1 SIR1 1 Unpublished Fields Lab Data
    View Screen YJR141W SIR1 1 Unpublished Fields Lab Data
    View Screen SPT21 SIR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..678] deduced N/A No confident structure predictions are available.
    2 View Details [154..298] deduced N/A No confident structure predictions are available.
    3 View Details [299..483] deduced N/A No confident structure predictions are available.
    4 View Details [484..678] PSI-BLAST 80.09691 S. cerevisiae Sir1 ORC-interaction domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle