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Protein Overview: MAE1

General Information:
Name(s) found: MAE1 / YKL029C [SGD]
Description(s) found:
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  • gi|6322823|ref|NP_012896.1| Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; Mae1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|547888|sp|P36013.1|MAOM_YEAST RecName: Full=NAD-dependent malic enzyme, mitochondrial; Short=NAD-ME; Flags: Precursor [NCBI NR]
  • pir||S37846 malate dehydrogenase homolog YKL029c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486030|emb|CAA81865.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P36013) NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) [Swiss-Prot]
  • NAD-dependent malic enzyme, mitochondrial OS=Saccharomyces cerevisiae GN=MAE1 PE=1 SV=1 [Swiss-Prot]
  • MAE1 Malic enzyme [mips]
  • Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids [SGD]
  • MAE1, Chr XI from 382354-384363, reverse complement [yeast_orfs2]
  • Chr XI from 382354-384363, reverse complement [yeastorf3.fasta]
  • Chr XI from 384363-382354, reverse complement [yeastorf5.fasta]
  • MAE1 SGDID:S0001512, Chr XI from 384368-382359, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Mae1p [Saccharomyces cerevisiae]gi|486030|emb|CAA81865.1| unnamed protein product [Saccharomyces cerevisiae]gi|547888|sp|P36013|MAOX_YEAST NAD-dependent malic enzyme (NAD-ME)gi|539291|pir||S37846 malate dehydrogenase homolog YKL029c - yeast (Saccharomy [nrdb_11152004_Chlamydomonas]
  • MAE1 SGDID:S000001512, Chr XI from 384368-382359, reverse complement, Verified ORF, "Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis o [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; Mae1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NAD-dependent malic enzyme (NAD-ME) [nr-271106-contam.fasta]
  • MAE1 SGDID:S000001512, Chr XI from 384368-382359, reverse complement, Verified ORF, "Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • NAD-dependent malic enzyme, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAE1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MAE1 SGDID:S000001512, Chr XI from 384725-382716, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" [yeast-030211-contam.fasta]
  • MAE1 SGDID:S000001512, Chr XI from 384725-382716, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" [20141208_orf_trans.fasta]
  • YKL029C SGDID:S000001512, Chr XI from 384725-382716, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: cellular amino acid metabolic process [IMPLink to PubMed article]
    pyruvate metabolic process [IMPLink to PubMed article]
    Molecular Function: malic enzyme activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTRLSVSV AARSQLTRSL TASRTAPLRR WPIQQSRLYS SNTRSHKATT TRENTFQKPY  60
   61 SDEEVTKTPV GSRARKIFEA PHPHATRLTV EGAIECPLES FQLLNSPLFN KGSAFTQEER 120
  121 EAFNLEALLP PQVNTLDEQL ERSYKQLCYL KTPLAKNDFM TSLRVQNKVL YFALIRRHIK 180
  181 ELVPIIYTPT EGDAIAAYSH RFRKPEGVFL DITEPDSIEC RLATYGGDKD VDYIVVSDSE 240
  241 GILGIGDQGI GGVRIAISKL ALMTLCGGIH PGRVLPVCLD VGTNNKKLAR DELYMGNKFS 300
  301 RIRGKQYDDF LEKFIKAVKK VYPSAVLHFE DFGVKNARRL LEKYRYELPS FNDDIQGTGA 360
  361 VVMASLIAAL KHTNRDLKDT RVLIYGAGSA GLGIADQIVN HMVTHGVDKE EARKKIFLMD 420
  421 RRGLILQSYE ANSTPAQHVY AKSDAEWAGI NTRSLHDVVE NVKPTCLVGC STQAGAFTQD 480
  481 VVEEMHKHNP RPIIFPLSNP TRLHEAVPAD LMKWTNNNAL VATGSPFPPV DGYRISENNN 540
  541 CYSFPGIGLG AVLSRATTIT DKMISAAVDQ LAELSPLREG DSRPGLLPGL DTITNTSARL 600
  601 ATAVILQALE EGTARIEQEQ VPGGAPGETV KVPRDFDECL QWVKAQMWEP VYRPMIKVQH 660
  661 DPSVHTNQL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CLU1 GCN20 MAE1
    View Details Krogan NJ, et al. (2006) BCH1 BCH2 CHS5 LAP2 MAE1
    View Details Gavin AC, et al. (2006) MAE1 PRS3 TOM1
    View Details Ho Y, et al. (2002) ACC1 ARG4 ARP2 AYR1 BGL2 CCT6 COR1 CPR6 ERG27 FAA1 FAA4 GLT1 GPT2 GSF2 LIA1 MAE1 NDE1 NPA3 OM45 PCT1 PDA1 PET10 PET9 PIL1 PRE10 PRO3 RET2 RMT2 RNR2 RPT4 RTN2 RVS161 SAP155 SAP185 SAP190 SEC18 SEC21 SEC26 SEC27 SEC28 SIT4 SMK1 TAP42 TIF34 TIF35 TPA1 YMR196W YNL181W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MAE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] MSA 2.072983 View MSA. No confident structure predictions are available.
    2 View Details [98..352]
    [647..669]    		 PSI-BLAST 1976.9897 Mitochondrial NAD(P)-dependenent malic enzyme
    3 View Details [353..646] PSI-BLAST 1976.9897 Mitochondrial NAD(P)-dependenent malic enzyme


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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