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Protein Overview: PTC3

General Information:
Name(s) found: PTC3 / YBL056W [SGD]
Description(s) found:
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  • gi|84028240|sp|P34221.3|PP2C3_YEAST RecName: Full=Protein phosphatase 2C homolog 3; Short=PP2C-3 [NCBI NR]
  • gi|6319415|ref|NP_009497.1| Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation; [NCBI NR]
  • pir||S39832 probable phosphoprotein phosphatase (EC 3.1.3.16) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|536086|emb|CAA84876.1| PTC3 [Saccharomyces cerevisiae] [NCBI NR]
  • sp|P34221|P2C3_YEAST Protein phosphatase 2C homolog 3 (PP2C-3) [NCBI NR]
  • gi|313742|emb|CAA80791.1| YBLO513 [Saccharomyces cerevisiae] [NCBI NR]
  • Protein phosphatase 2C homolog 3 OS=Saccharomyces cerevisiae GN=PTC3 PE=1 SV=3 [Swiss-Prot]
  • (P34221) Protein phosphatase 2C homolog 3 (EC 3.1.3.16) (PP2C-3) [Swiss-Prot]
  • PTC3 Ser/thr protein phosphatase PP2C [mips]
  • Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation [SGD]
  • PTC3, Chr II from 113724-115130 [yeast_orfs2]
  • Chr II from 113724-115130 [yeastorf3.fasta]
  • PTC3 SGDID:S0000152, Chr II from 113727-115133, Verified ORF [yeastflysequest.fasta]
  • PTC3 SGDID:S0000152, Chr II from 113765-115171, Verified ORF [10112005cervSGD.fasta]
  • Ptc3p [Saccharomyces cerevisiae]gi|313742|emb|CAA80791.1| YBLO513 [Saccharomyces cerevisiae]gi|536086|emb|CAA84876.1| PTC3 [Saccharomyces cerevisiae]gi|465515|sp|P34221|P2C3_YEAST Protein phosphatase 2C homolog 3 (PP2C-3)gi|542309|pir||S39832 probable [nrdb_11152004_Chlamydomonas]
  • PTC3 SGDID:S000000152, Chr II from 113765-115171, Verified ORF, "Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PTC3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YBLO513 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation; Ptc3p [Saccharomyces cerevi [nr-271106-contam.fasta]
  • Protein phosphatase 2C homolog 3 (PP2C-3) [nr-271106-contam.fasta]
  • PTC3 SGDID:S000000152, Chr II from 113765-115171, Verified ORF, "Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 468 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: inactivation of MAPK activity involved in osmosensory signaling pathway [IGILink to PubMed articleLink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article]
    regulation of cyclin-dependent protein kinase activity [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IDA][IEA]
    phosphoprotein phosphatase activity [IEA]
    metal ion binding [IEA]
    catalytic activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQILSNPII DKEHHSGTDC LTAFGLCAMQ GWRMSMEDAH IVEPNLLAES DEEHLAFYGI  60
   61 FDGHGGSSVA EFCGSKMISI LKKQESFKSG MLEQCLIDTF LATDVELLKD EKLKDDHSGC 120
  121 TATVILVSQL KKLLICANSG DSRTVLSTGG NSKAMSFDHK PTLLSEKSRI VAADGFVEMD 180
  181 RVNGNLALSR AIGDFEFKSN TKLGPHEQVV TCVPDIICHN LNYDEDEFVI LACDGIWDCL 240
  241 TSQECVDLVH YGISQGNMTL SDISSRIVDV CCSPTTEGSG IGCDNMSISI VALLKENESE 300
  301 SQWFERMRSK NYNIQTSFVQ RRKSIFDFHD FSDDDNEVFA ITTKKLQDRL NRSKDNDDME 360
  361 IDDLDTELDS SATPSKLSGE DRTGPIDLFS LEALLEAGIQ IRQRPSSDSD GNTSYFHGAS 420
  421 LSDMLASLSN AAAGETEPND ADDNDDNDGE ENGKNENAKK GSKIEEIE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PAA1 PTC3
    View Details Krogan NJ, et al. (2006) PAA1 PTC2 PTC3 PTC4 VPS34
    View Details Gavin AC, et al. (2006) PAA1 PTC3
    View Details Gavin AC, et al. (2002) ENP1 HRR25 PAA1 PFK1 PTC3 RAD50 TSR1 VPS15
    View Details Ho Y, et al. (2002) AAC3 AHA1 ATP3 BEM2 COP1 ECM10 ECM29 GCD11 HOM3 HOR2 ILV2 OYE2 PAA1 PIL1 PRB1 PTC3 RAD52 RAD55 RAD59 REP1 RHR2 SEC27 SEC53 TCB1 TDA10 TEF4 UBA1 VMA8 YER138C YHR033W YPT31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PTC3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..303] PSI-BLAST 499.85005 Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
    2 View Details [304..377] PSI-BLAST 499.85005 Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
    3 View Details [378..468] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.29765002420868 bayes_pls_golite062009
  • phosphatase activity
    		•  6.46633224572308 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.25564034681743 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  5.66354576593165 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.62997267604309 bayes_pls_golite062009
  • hydrolase activity
    		•  2.5631136269171 bayes_pls_golite062009
  • binding
    		•  1.74689317666387 bayes_pls_golite062009
  • catalytic activity
    		•  1.53401212718168 bayes_pls_golite062009
  • protein binding
    		•  0.425331902048676 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle