Protein Overview: TOD6

General Information:
Name(s) found:	TOD6 / YBL054W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319417\|ref\|NP_009499.1\| Protein of unknown function involved in rRNA and ribosome biosynthesis; Ybl054wp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S39834 myb-related protein YBL054w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|536082\|emb\|CAA84874.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|51012701\|gb\|AAT92644.1\| YBL054W [Saccharomyces cerevisiae] [NCBI NR] gi\|465513\|sp\|P34219.1\|TOD6_YEAST RecName: Full=Transcriptional regulatory protein TOD6; AltName: Full=Twin of DOT6; AltName: Full=PAC-binding factor 1 [NCBI NR] gi\|313744\|emb\|CAA80793.1\| YBLO509 [Saccharomyces cerevisiae] [NCBI NR] Myb domain-containing protein YBL054W OS=Saccharomyces cerevisiae GN=YBL054W PE=1 SV=1 [Swiss-Prot] Transcriptional regulatory protein TOD6 OS=Saccharomyces cerevisiae GN=TOD6 PE=1 SV=1 [Swiss-Prot] Putative transcription factor [mips] PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne [SGD] YBL054W, Chr II from 117551-119128 [yeast_orfs2] Chr II from 117551-119128 [yeastorf3.fasta] (P34219) Hypothetical 59.2 kDa protein in PTC3-SAS3 intergenic region [4932.FASTACCERV.txt] YBL054W SGDID:S0000150, Chr II from 117554-119131, Uncharacterized ORF [yeastflysequest.fasta] YBL054W SGDID:S0000150, Chr II from 117592-119169, Uncharacterized ORF [10112005cervSGD.fasta] Ybl054wp [Saccharomyces cerevisiae]gi\|51012701\|gb\|AAT92644.1\| YBL054W [Saccharomyces cerevisiae]gi\|313744\|emb\|CAA80793.1\| YBLO509 [Saccharomyces cerevisiae]gi\|536082\|emb\|CAA84874.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|542307\|pir\|\|S398 [nrdb_11152004_Chlamydomonas] YBL054W SGDID:S000000150, Chr II from 117592-119169, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YBL054W SGDID:S000000150, Chr II from 117592-119169, Uncharacterized ORF, "Protein of unknown function involved in rRNA and ribosome biosynthesis" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] TOD6 SGDID:S000000150, Chr II from 117592-119169, Verified ORF, "Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Dot6p; contains chromatin specific SANT domain" [yeast-200209-contam.fasta] hypothetical protein; Ybl054wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YBL054W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Myb domain-containing protein YBL054W [nr-271106-contam.fasta] YBLO509 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TOD6 SGDID:S000000150, Chr II from 117592-119169, Verified ORF, "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] TOD6 SGDID:S000000150, Chr II from 117592-119169, Verified ORF, "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne" [SGDyeast.20101221.fasta] Transcriptional regulatory protein TOD6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOD6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TOD6 SGDID:S000000150, Chr II from 117589-119166, Genome Release 64-1-1, Verified ORF, "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne" [yeast-030211-contam.fasta] TOD6 SGDID:S000000150, Chr II from 117589-119166, Genome Release 64-2-1, Verified ORF, "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization" [20141208_orf_trans.fasta] YBL054W SGDID:S000000150, Chr II from 117589-119166, Genome Release 64-1-1, Verified ORF, "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	525 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	ribosome biogenesis [RCA]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLPKLSSVS VSSGHVSANS HGFSILSKHP HPNNLVHSHS LSHTNAKSHL PISSTSTKEN  60
   61 STNKEEAESL KKNNPSSWDP SDDIKLRHLK EIKNLGWKEI AHHFPNRTPN ACQFRWRRLK 120
  121 SGNLKSNKTA VIDINKLFGV YATGDATPSA GTPSAEEAVK EEAVEDEDIT AGSSAIEDSP 180
  181 PDFKPLVKPK YMDRKLITQR STSTFSDHEP QHTKPRKLFV KPRSFSHSIT TNTPNVKTAQ 240
  241 QTNLSLYNTT SAKTNKAVNS NDYENIGLVP KIIIRSRRNS FIPSTQIPHS TTKTRKNSHS 300
  301 VISSRRSSFN MMHSRRSSFN SHAPTEPISR RASLVVSPYM SPRRLSTSQS VHYHPQHQYY 360
  361 LNPIASPNCK TDHANDKITH TRTFLDMQKF ANKHPWSRED DEVLLNNTKD KQNHLSPLEI 420
  421 SIVLPNNRSE LEIQQRMDYL KRKGRVSGFH TNEGCKDEEE EDDIDPLHKE NGINTPSQQS 480
  481 QNYGMLEAKH DNPKSSELSS MTSANDIRNE QDELPGINSI FKNIF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		RPN11 RPN12 RPN13 RPN2 RPT1 RPT2 RPT3 RPT4 TOD6
View Details	Krogan NJ, et al. (2006)		CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	TOD6	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..77]	deduced	N/A	No confident structure predictions are available.
2	View Details	[78..168]	PSI-BLAST	3.045757	c-Myb, DNA-binding domain
3	View Details	[169..525]	deduced	N/A	No confident structure predictions are available.

Protein Overview: TOD6

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: