Protein Overview: MRPL16

General Information:
Name(s) found:	MRPL16 / YBL038W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319433\|ref\|NP_009515.1\| Mitochondrial ribosomal protein of the large subunit; Mrpl16p [Saccharomyces cerevisiae] [NCBI NR] gi\|585896\|sp\|P38064.1\|RM16_YEAST RecName: Full=54S ribosomal protein L16, mitochondrial; AltName: Full=YmL47; Flags: Precursor [NCBI NR] gi\|536051\|emb\|CAA84858.1\| MRPL16 [Saccharomyces cerevisiae] [NCBI NR] gi\|463270\|emb\|CAA55056.1\| L16 ribosomal protein [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50292 ribosomal protein L16 precursor, mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR] 54S ribosomal protein L16, mitochondrial OS=Saccharomyces cerevisiae GN=MRPL16 PE=1 SV=1 [Swiss-Prot] MRPL16 Mitochondrial ribosomal protein, large subunit [mips] Mitochondrial ribosomal protein of the large subunit [SGD] MRPL16, Chr II from 146149-146847 [yeast_orfs2] Chr II from 146149-146847 [yeastorf3.fasta] (P38064) 60S ribosomal protein L16, mitochondrial precursor (YmL47) [4932.FASTACCERV.txt] MRPL16 SGDID:S0000134, Chr II from 146152-146850, Verified ORF [yeastflysequest.fasta] MRPL16 SGDID:S0000134, Chr II from 146190-146888, Verified ORF [10112005cervSGD.fasta] Mitochondrial ribosomal protein of the large subunit [Saccharomyces cerevisiae]gi\|463270\|emb\|CAA55056.1\| L16 ribosomal protein [Saccharomyces cerevisiae]gi\|536051\|emb\|CAA84858.1\| MRPL16 [Saccharomyces cerevisiae]gi\|1363829\|pir\|\|S50292 ribosomal protein [nrdb_11152004_Chlamydomonas] MRPL16 SGDID:S000000134, Chr II from 146190-146888, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] L16 ribosomal protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] MRPL16 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial ribosomal protein of the large subunit; Mrpl16p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] 60S ribosomal protein L16, mitochondrial precursor (YmL47) [nr-271106-contam.fasta] [chemostatdb.fasta] 54S ribosomal protein L16, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRPL16 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MRPL16 SGDID:S000000134, Chr II from 146187-146885, Genome Release 64-1-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [yeast-030211-contam.fasta] MRPL16 SGDID:S000000134, Chr II from 146187-146885, Genome Release 64-2-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetically lethal with hac1 mutant suggesting a role in the maturation of secretory proteins" [20141208_orf_trans.fasta] TR6487\|c0_g1_i1\|g.4580 ORF TR6487\|c0_g1_i1\|g.4580 TR6487\|c0_g1_i1\|m.4580 type:complete len:233 (+) TR6487\|c0_g1_i1:73-771(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YBL038W SGDID:S000000134, Chr II from 146187-146885, Genome Release 64-1-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_4574\|g.3484 ORF asmbl_4574\|g.3484 asmbl_4574\|m.3484 type:complete len:233 (+) asmbl_4574:80-778(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_4579\|g.2820 ORF ID=asmbl_4579\|g.2820 ID=asmbl_4579\|m.2820 type:complete len:233 (+) ID=asmbl_4579:80-778(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	232 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial large ribosomal subunit [IDA]
Biological Process:	translation [IDA]
Molecular Function:	structural constituent of ribosome [IDA] peptidyltransferase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPYLTRMNL SIKMGGLTLK ESSPNAFLNN TTIARRFKHE YAPRFKIVQK KQKGRVPVRT  60
   61 GGSIKGSTLQ FGKYGLRLKS EGIRISAQQL KEADNAIMRY VRPLNNGHLW RRLCTNVAVC 120
  121 IKGNETRMGK GKGGFDHWMV RVPTGKILFE INGDDLHEKV AREAFRKAGT KLPGVYEFVS 180
  181 LDSLVRVGLH SFKNPKDDPV KNFYDENAKK PSKKYLNILK SQEPQYKLFR GR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		IMG1 IMG2 MHR1 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL20 MRPL23 MRPL24 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL7 MRPL8 YML6
View Details	(MIPS) Mewes HW, et al. (2004)		IMG1 IMG2 MNP1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 RML2 RTC6 YDR115W YML6
View Details	Krogan NJ, et al. (2006)		ACO2 DRN1 MRPL16
View Details	Gavin AC, et al. (2006)		ATG26 BUD3 MRPL10 MRPL16 MRPL23 MRPL4 MRPL51
View Details	Gavin AC, et al. (2002)		ATG26 BEM2 BUD3 COP1 CYR1 HRR25 IMG1 IMG2 IML1 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NUG1 PRP43 RET2 ROM2 RTC6 SEC1 SEC26 SEC27 SIN4 SNF2 SWI3 SYP1 TAF5 UTP20 YDR115W YML6
View Details	Qiu et al. (2008)		IMG1 IMG2 MAM33 MHR1 MNP1 MRP1 MRP10 MRP13 MRP17 MRP2 MRP20 MRP21 MRP4 MRP49 MRP51 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 NAM9 PET123 RML2 RSM10 RSM18 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 RTC6 SWS2 VAR1 YDR115W YML6 YMR31

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	KAP104	MRPL16	1	Unpublished Fields Lab Data
View Screen	CTF13	MRPL16	1	Unpublished Fields Lab Data
View Screen	NAF1	MRPL16	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MRPL16	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..232]	PSI-BLAST	155.9897	No description for 1lnrK_ was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
structural constituent of ribosome	9.80692012906383	bayes_pls_golite062009
structural molecule activity	9.22985932721781	bayes_pls_golite062009
peptidyltransferase activity	3.83536146028392	bayes_pls_golite062009
transferase activity, transferring amino-acyl groups	0.386783133410145	bayes_pls_golite062009
catalytic activity	0.145440139643068	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2