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Protein Overview: ACO2

General Information:
Name(s) found: ACO2 / YJL200C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 789 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: aconitate hydratase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSSANRFYI KRHLATHANM FPSVSKNFQT KVPPYAKLLT NLDKIKQITN NAPLTLAEKI  60
   61 LYSHLCDPEE SITSSDLSTI RGNKYLKLNP DRVAMQDASA QMALLQFMTT GLNQTSVPAS 120
  121 IHCDHLIVGK DGETKDLPSS IATNQEVFDF LESCAKRYGI QFWGPGSGII HQIVLENFSA 180
  181 PGLMMLGTDS HTPNAGGLGA IAIGVGGADA VDALTGTPWE LKAPKILGVK LTGKLNGWST 240
  241 PKDVITKLAG LLTVRGGTGY IVEYFGEGVS TLSCTGMATI CNMGAEIGAT TSTFPYQEAH 300
  301 KRYLQATNRA EVAEAADVAL NKFNFLRADK DAQYDKVIEI DLSAIEPHVN GPFTPDLSTP 360
  361 ISQYAEKSLK ENWPQKVSAG LIGSCTNSSY QDMSRVVDLV KQASKAGLKP RIPFFVTPGS 420
  421 EQIRATLERD GIIDIFQENG AKVLANACGP CIGQWNREDV SKTSKETNTI FTSFNRNFRA 480
  481 RNDGNRNTMN FLTSPEIVTA MSYSGDAQFN PLTDSIKLPN GKDFKFQPPK GDELPKRGFE 540
  541 HGRDKFYPEM DPKPDSNVEI KVDPNSDRLQ LLEPFKPWNG KELKTNVLLK VEGKCTTDHI 600
  601 SAAGVWLKYK GHLENISYNT LIGAQNKETG EVNKAYDLDG TEYDIPGLMM KWKSDGRPWT 660
  661 VIAEHNYGEG SAREHAALSP RFLGGEILLV KSFARIHETN LKKQGVLPLT FANESDYDKI 720
  721 SSGDVLETLN LVDMIAKDGN NGGEIDVKIT KPNGESFTIK AKHTMSKDQI DFFKAGSAIN 780
  781 YIGNIRRNE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACO2 DRN1 MRPL16

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ACO2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..572]
    [603..614]    		 PSI-BLAST 11000.0 Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
    2 View Details [573..602]
    [615..789]    		 PSI-BLAST 11000.0 Aconitase A, C-terminal domain; Aconitase A, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-isopropylmalate dehydratase activity
    		•  11.6597692115322 bayes_pls_golite062009
  • aconitate hydratase activity
    		•  5.86356477922338 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.49717480487827 bayes_pls_golite062009
  • structural molecule activity
    		•  5.20352686802457 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • mRNA binding
    		•  2.2758554402042 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.25736437672211 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.08349115784849 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.04845291489052 bayes_pls_golite062009
  • lyase activity
    		•  2.0080619912194 bayes_pls_golite062009
  • RNA binding
    		•  2.00311670878109 bayes_pls_golite062009
  • metal cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • binding
    		•  1.67914740974449 bayes_pls_golite062009
  • DNA binding
    		•  1.6436451615422 bayes_pls_golite062009
  • iron-responsive element binding
    		•  1.1980380564483 bayes_pls_golite062009
  • iron ion binding
    		•  1.12961684198784 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  1.11810757572823 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.342428816025605 bayes_pls_golite062009
  • protein binding
    		•  0.232638130896339 bayes_pls_golite062009
  • cation binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • metal ion binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • ion binding
    		•  0.0228992031160024 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle