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View Structure Prediction Details

Protein: ACO2
Organism: Saccharomyces cerevisiae
Length: 789 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACO2.

Description E-value Query
Range		 Subject
Range
ACON2_YEAST - Homocitrate dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=A...
ACO2 - Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cyc...
 0.0 [1..789] [1..789]
gi|109451582, gi... - gi|168277800|dbj|BAG10878.1| aconitate hydratase [synthetic construct], gi|123998321|gb|ABM86762.1| ...
ACO2 - aconitase 2, mitochondrial
 0.0 [4..787] [16..780]
gi|108227 - pir||A35544 aconitate hydratase (EC 4.2.1.3) precursor, mitochondrial [validated] - pig
ACON_PIG - Aconitate hydratase, mitochondrial OS=Sus scrofa GN=ACO2 PE=1 SV=1
 0.0 [4..788] [16..781]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [4..788] [16..781]
ACON_MOUSE - Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1
 0.0 [4..787] [16..780]
ACON_BOVIN - (P20004) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase)
 0.0 [4..787] [16..780]

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Predicted Domain #1
Region A:
Residues: [1-572] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSSANRFYI KRHLATHANM FPSVSKNFQT KVPPYAKLLT NLDKIKQITN NAPLTLAEKI  60
   61 LYSHLCDPEE SITSSDLSTI RGNKYLKLNP DRVAMQDASA QMALLQFMTT GLNQTSVPAS 120
  121 IHCDHLIVGK DGETKDLPSS IATNQEVFDF LESCAKRYGI QFWGPGSGII HQIVLENFSA 180
  181 PGLMMLGTDS HTPNAGGLGA IAIGVGGADA VDALTGTPWE LKAPKILGVK LTGKLNGWST 240
  241 PKDVITKLAG LLTVRGGTGY IVEYFGEGVS TLSCTGMATI CNMGAEIGAT TSTFPYQEAH 300
  301 KRYLQATNRA EVAEAADVAL NKFNFLRADK DAQYDKVIEI DLSAIEPHVN GPFTPDLSTP 360
  361 ISQYAEKSLK ENWPQKVSAG LIGSCTNSSY QDMSRVVDLV KQASKAGLKP RIPFFVTPGS 420
  421 EQIRATLERD GIIDIFQENG AKVLANACGP CIGQWNREDV SKTSKETNTI FTSFNRNFRA 480
  481 RNDGNRNTMN FLTSPEIVTA MSYSGDAQFN PLTDSIKLPN GKDFKFQPPK GDELPKRGFE 540
  541 HGRDKFYPEM DPKPDSNVEI KVDPNSDRLQ LL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [603-614] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGVWLKYKGH LE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 5acn__
Description: Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3-isopropylmalate dehydratase activity 11.6597692115322 bayes_pls_golite062009
aconitate hydratase activity 5.86356477922338 bayes_pls_golite062009
structural constituent of ribosome 5.49717480487827 bayes_pls_golite062009
structural molecule activity 5.20352686802457 bayes_pls_golite062009
catalytic activity 2.4040324437254 bayes_pls_golite062009
mRNA binding 2.2758554402042 bayes_pls_golite062009
nucleic acid binding 2.25736437672211 bayes_pls_golite062009
carbon-oxygen lyase activity 2.08349115784849 bayes_pls_golite062009
hydro-lyase activity 2.04845291489052 bayes_pls_golite062009
lyase activity 2.0080619912194 bayes_pls_golite062009
RNA binding 2.00311670878109 bayes_pls_golite062009
metal cluster binding 1.70706327499066 bayes_pls_golite062009
iron-sulfur cluster binding 1.70706327499066 bayes_pls_golite062009
binding 1.67914740974449 bayes_pls_golite062009
DNA binding 1.6436451615422 bayes_pls_golite062009
iron-responsive element binding 1.1980380564483 bayes_pls_golite062009
iron ion binding 1.12961684198784 bayes_pls_golite062009
4 iron, 4 sulfur cluster binding 1.11810757572823 bayes_pls_golite062009
transition metal ion binding 0.342428816025605 bayes_pls_golite062009
protein binding 0.232638130896339 bayes_pls_golite062009
cation binding 0.0272064751959212 bayes_pls_golite062009
metal ion binding 0.0272064751959212 bayes_pls_golite062009
ion binding 0.0228992031160024 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [573-602] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPFKPWNGKE LKTNVLLKVE GKCTTDHISA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [615-789] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NISYNTLIGA QNKETGEVNK AYDLDGTEYD IPGLMMKWKS DGRPWTVIAE HNYGEGSARE  60
   61 HAALSPRFLG GEILLVKSFA RIHETNLKKQ GVLPLTFANE SDYDKISSGD VLETLNLVDM 120
  121 IAKDGNNGGE IDVKITKPNG ESFTIKAKHT MSKDQIDFFK AGSAINYIGN IRRNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 5acn__
Description: Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle