YRC Public Data Repository - Protein Structure Prediction

Protein:	FBpp0304917, R-P...
Organism:	Drosophila melanogaster
Length:	184 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0304917, R-P....

Description	E-value	Query Range	Subject Range
gi\|89257579 - gi\|89257579\|gb\|ABD65068.1\| GTP-binding protein, putative [Brassica oleracea]	203.0	[0..4]	[183..9]
gi\|46229098, gi\|... - gi\|46229098\|gb\|EAK89947.1\| RAS small GTpases RIC1/ypt1 [Cryptosporidium parvum Iowa II], gi\|32398899... gi\|54658806 - gi\|54658806\|gb\|EAL37422.1\| small GTP binding protein rab1a [Cryptosporidium hominis] gi\|66475702 - gi\|66475702\|ref\|XP_627667.1\| RAS small GTpases RIC1/ypt1 [Cryptosporidium parvum Iowa II] gi\|67619548 - gi\|67619548\|ref\|XP_667653.1\| small GTP binding protein rab1a [Cryptosporidium hominis TU502]	202.0	[0..4]	[179..9]
gi\|28924807, gi\|... - gi\|32418088\|ref\|XP_329522.1\| GTP-BINDING PROTEIN YPT1 [Neurospora crassa], gi\|28924807\|gb\|EAA33910.1... gi\|85109909 - gi\|85109909\|ref\|XP_963146.1\| GTP-BINDING PROTEIN YPT1 [Neurospora crassa OR74A]	202.0	[0..4]	[183..49]
gi\|303734, gi\|738942 - gi\|738942\|prf\|\|2001457K GTP-binding protein, gi\|303734\|dbj\|BAA02118.1\| GTP-binding protein [Pisum sa... gi\|1098293, gi\|4... - pir\|\|S41430 GTP-binding protein, ras-like (clone vfa-ypt1) - fava bean, gi\|452359\|emb\|CAA82707.1\| g...	202.0	[0..4]	[183..9]
RIC1_ORYSJ - Ras-related protein RIC1 OS=Oryza sativa subsp. japonica GN=RIC1 PE=2 SV=2 gi\|125526416 - gi\|125526416\|gb\|EAY74530.1\| hypothetical protein OsI_02420 [Oryza sativa Indica Group] RIC1_ORYSA - Ras-related protein RIC1 - Oryza sativa (Rice)	202.0	[0..4]	[184..9]
gi\|16974365 - gi\|16974365\|gb\|AAL31108.1\| AT4g17530/dl4800c [Arabidopsis thaliana]	202.0	[0..4]	[183..9]
gi\|50738954 - gi\|50738954\|ref\|XP_419342.1\| PREDICTED: similar to ras-related protein [Gallus gallus]	202.0	[0..4]	[171..200]
gi\|1370166 - gi\|1370166\|emb\|CAA98160.1\| RAB1C [Lotus japonicus]	201.0	[0..4]	[183..9]
RIC1_ORYSA - (P40392) Ras-related protein RIC1	201.0	[0..4]	[184..9]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREYKIVVLG SGGVGKSALT VQFVQCIFVE KYDPTIEDSY RKQVEVDGQQ CMLEILDTAG  60
   61 TEQFTAMRDL YMKNGQGFVL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MVLVGNKCDL 120
  121 EEERVVGKEL GKNLATQFNC AFMETSAKAK VNVNDIFYDL VRQINKKSPE KKQKKPKKSL 180
  181 CVLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.39794
Match:	1guaA
Description:	Rap1A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTPase activity	4.52394549632777	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
microtubule motor activity	3.91769993918004	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
actin binding	3.33639699088484	bayes_pls_golite062009
microfilament motor activity	3.17800963620802	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
structural constituent of ribosome	3.070470376968	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
G-protein coupled receptor activity	2.3505608190884	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
actin filament binding	2.24723363507804	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	2.12727614888121	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
structural molecule activity	2.08211451183607	bayes_pls_golite062009
tubulin binding	1.92557767696163	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	1.88153949603611	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
	1.86855842486607	bayes_pls_golite062009
purine ribonucleotide binding	1.85943679361938	bayes_pls_golite062009
ribonucleotide binding	1.85937484083653	bayes_pls_golite062009
purine nucleotide binding	1.8521191028835	bayes_pls_golite062009
nucleotide binding	1.84603132945448	bayes_pls_golite062009
microtubule binding	1.84561785126784	bayes_pls_golite062009
kinase activity	1.80889641165674	bayes_pls_golite062009
structural constituent of muscle	1.75982319871463	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.60386625568858	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
actin-dependent ATPase activity	1.58897222423517	bayes_pls_golite062009
ATP binding	1.5859264197035	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
adenyl ribonucleotide binding	1.55520429131224	bayes_pls_golite062009
adenyl nucleotide binding	1.53158018507951	bayes_pls_golite062009
apolipoprotein receptor activity	1.52496551152043	bayes_pls_golite062009
syntaxin-13 binding	1.52496551152043	bayes_pls_golite062009
apolipoprotein A-I binding	1.52496551152043	bayes_pls_golite062009
apolipoprotein A-I receptor activity	1.52496551152043	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
transmembrane receptor activity	1.26314334516725	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
DNA-dependent ATPase activity	1.2155186842031	bayes_pls_golite062009
receptor activity	1.20313362488821	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.14475274823167	bayes_pls_golite062009
signal transducer activity	1.13474466330485	bayes_pls_golite062009
molecular transducer activity	1.13474466330485	bayes_pls_golite062009
protein kinase activity	1.12864835254143	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
peptide-transporting ATPase activity	0.911425383309011	bayes_pls_golite062009
transcription activator activity	0.889929694023098	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
transferase activity	0.871779313294914	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
structure-specific DNA binding	0.782430219754236	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
peptide transporter activity	0.73541731084591	bayes_pls_golite062009
DNA helicase activity	0.72881469450553	bayes_pls_golite062009
potassium channel activity	0.694411056320469	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.650964453464311	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
steroid hormone receptor binding	0.647625526012423	bayes_pls_golite062009
calcium channel activity	0.636216614902039	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
cell surface binding	0.618263399939881	bayes_pls_golite062009
double-stranded DNA binding	0.6071273686445	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.5886142102548	bayes_pls_golite062009
plus-end-directed microtubule motor activity	0.567883621045161	bayes_pls_golite062009
sequence-specific DNA binding	0.543891899378373	bayes_pls_golite062009
DNA clamp loader activity	0.543512707823441	bayes_pls_golite062009
DNA strand annealing activity	0.495691434532349	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
signal sequence binding	0.42240724331108	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
hormone receptor binding	0.351501100511918	bayes_pls_golite062009
protein serine/threonine kinase activity	0.345873656782869	bayes_pls_golite062009
peptide binding	0.304703625340488	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
myosin binding	0.274885859454447	bayes_pls_golite062009
voltage-gated calcium channel activity	0.25979628626254	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.248918847596573	bayes_pls_golite062009
nuclear hormone receptor binding	0.246160342138071	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
signal recognition particle binding	0.20866768220789	bayes_pls_golite062009
RNA helicase activity	0.18426050934025	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
RNA-dependent ATPase activity	0.14606996093053	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.13050483816765	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.12351419478929	bayes_pls_golite062009
minus-end directed microfilament motor activity	0.103268955687259	bayes_pls_golite062009
GBD domain binding	0.0922383758186687	bayes_pls_golite062009
RNA binding	0.0693163519626152	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: