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View Structure Prediction Details

Protein: PRKCB1
Organism: Homo sapiens
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRKCB1.

Description E-value Query
Range		 Subject
Range
KPCB_RAT - Protein kinase C beta type OS=Rattus norvegicus GN=Prkcb PE=1 SV=3
KPCB_MOUSE - Protein kinase C beta type OS=Mus musculus GN=Prkcb PE=1 SV=4
 0.0 [1..671] [1..671]
gi|109127926 - gi|109127926|ref|XP_001095880.1| PREDICTED: protein kinase C, beta isoform 1 [Macaca mulatta]
 0.0 [1..671] [1..671]
KPCB_RABIT - Protein kinase C beta type OS=Oryctolagus cuniculus GN=PRKCB PE=2 SV=3
 0.0 [1..671] [1..671]
KPCB_MOUSE - Protein kinase C beta type OS=Mus musculus GN=Prkcb PE=1 SV=3
sp|P68403-2|KPCB_RAT - Isoform Beta-II of Protein kinase C beta type OS=Rattus norvegicus GN=Prkcb
gi|117616654 - gi|117616654|gb|ABK42345.1| protein kinase C beta2 [synthetic construct]
 0.0 [1..669] [1..668]
KPCB_BOVIN - Protein kinase C beta type OS=Bos taurus GN=PRKCB PE=2 SV=3
 0.0 [1..669] [1..668]
gi|190692055, gi... - gi|254071255|gb|ACT64387.1| protein kinase C, beta 1 protein [synthetic construct], gi|190692055|gb|...
gi|189969, gi|35... - pir||KIHUC2 protein kinase C (EC 2.7.1.-) beta-II - human, gi|35493|emb|CAA30130.1| unnamed protein...
 0.0 [1..669] [1..668]

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Predicted Domain #1
Region A:
Residues: [1-93] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF  60
   61 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.71782887289779 bayes_pls_golite062009
transcription regulator activity 2.86705824967236 bayes_pls_golite062009
binding 2.79128751898373 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10625597744594 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
kinase activity 2.03632850156074 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
nucleic acid binding 1.91441035614579 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.8531437045627 bayes_pls_golite062009
protein kinase activity 1.62921423829738 bayes_pls_golite062009
transferase activity 1.4550521488922 bayes_pls_golite062009
transcription factor activity 1.39657429296564 bayes_pls_golite062009
signal transducer activity 1.25507073225414 bayes_pls_golite062009
molecular transducer activity 1.25507073225414 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.10685156896266 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
protein serine/threonine kinase activity 0.956859696337723 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
kinase binding 0.494958567742569 bayes_pls_golite062009
cation binding 0.416345209135028 bayes_pls_golite062009
metal ion binding 0.416345209135028 bayes_pls_golite062009
ion binding 0.411417584934096 bayes_pls_golite062009
myosin heavy chain kinase activity 0.362457326055781 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [94-179] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASDDPRSKHK FKIHTYSSPT FCDHCGSLLY GLIHQGMKCD TCMMNVHKRC VMNVPSLCGT  60
   61 DHTERRGRIY IQAHIDRDVL IVLVRD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.12
Match: 1tbnA
Description: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.46734661087649 bayes_pls_golite062009
transcription regulator activity 2.82097223032126 bayes_pls_golite062009
binding 2.71288992341677 bayes_pls_golite062009
GTPase regulator activity 2.43859890356027 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.42148330229896 bayes_pls_golite062009
protein binding 2.2604757016607 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.07238897772131 bayes_pls_golite062009
DNA binding 2.05972958088217 bayes_pls_golite062009
kinase activity 2.00903309297046 bayes_pls_golite062009
nucleic acid binding 1.91592331431516 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.83466699022067 bayes_pls_golite062009
enzyme regulator activity 1.78173505822139 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 1.76217210688028 bayes_pls_golite062009
small GTPase regulator activity 1.73820712435638 bayes_pls_golite062009
protein kinase activity 1.61903873760762 bayes_pls_golite062009
transferase activity 1.45394179515146 bayes_pls_golite062009
transcription factor activity 1.38590948364516 bayes_pls_golite062009
signal transducer activity 1.25050856744516 bayes_pls_golite062009
molecular transducer activity 1.25050856744516 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.969266093401353 bayes_pls_golite062009
protein serine/threonine kinase activity 0.93378879973188 bayes_pls_golite062009
Ras GTPase activator activity 0.854618067843974 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.716569837044966 bayes_pls_golite062009
GTPase activator activity 0.531562206762648 bayes_pls_golite062009
kinase binding 0.409606963040614 bayes_pls_golite062009
cation binding 0.311967762495891 bayes_pls_golite062009
metal ion binding 0.311967762495891 bayes_pls_golite062009
ion binding 0.307697800147455 bayes_pls_golite062009
catalytic activity 0.216721136299042 bayes_pls_golite062009
enzyme activator activity 0.160536263083511 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [180-602] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKNLVPMDPN GLSDPYVKLK LIPDPKSESK QKTKTIKCSL NPEWNETFRF QLKESDKDRR  60
   61 LSVEIWDWDL TSRNDFMGSL SFGISELQKA SVDGWFKLLS QEEGEYFNVP VPPEGSEANE 120
  121 ELRQKFERAK ISQGTKVPEE KTTNTVSKFD NNGNRDRMKL TDFNFLMVLG KGSFGKVMLS 180
  181 ERKGTDELYA VKILKKDVVI QDDDVECTMV EKRVLALPGK PPFLTQLHSC FQTMDRLYFV 240
  241 MEYVNGGDLM YHIQQVGRFK EPHAVFYAAE IAIGLFFLQS KGIIYRDLKL DNVMLDSEGH 300
  301 IKIADFGMCK ENIWDGVTTK TFCGTPDYIA PEIIAYQPYG KSVDWWAFGV LLYEMLAGQA 360
  361 PFEGEDEDEL FQSIMEHNVA YPKSMSKEAV AICKGLMTKH PGKRLGCGPE GERDIKEHAF 420
  421 FRY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.39794
Match: 1opkA
Description: Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
phosphoinositide 3-kinase binding 3.43994026029707 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
SH2 domain binding 3.03401803018883 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
acetylcholine receptor activator activity 2.31137729067208 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
telethonin binding 2.27062712605521 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
GTPase activity 2.07905155389729 bayes_pls_golite062009
insulin binding 2.0719180171079 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
PTB domain binding 1.96099803532698 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
phosphoinositide 3-kinase activity 1.5013287968167 bayes_pls_golite062009
1-phosphatidylinositol-3-kinase activity 1.43713739644553 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
alpha-actinin binding 1.38861866085902 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
epidermal growth factor receptor binding 1.24312972088703 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
structural constituent of muscle 1.19908793854422 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
structural molecule activity 1.10436308210353 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 1.03150090191995 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
transcription repressor activity 0.889321498544699 bayes_pls_golite062009
transcription activator activity 0.846644791435606 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
vinculin binding 0.666656406096231 bayes_pls_golite062009
JUN kinase kinase kinase activity 0.63080698970012 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
insulin receptor activity 0.585036697436369 bayes_pls_golite062009
ErbB-2 class receptor binding 0.547121592096699 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding 0.372842462336059 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
photoreceptor activity 0.187612589250841 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
cation binding 0.046173055856133 bayes_pls_golite062009
metal ion binding 0.046173055856133 bayes_pls_golite062009
ion binding 0.0389662058697694 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.0386657159233388 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [603-671] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDWEKLERKE IQPPYKPKAR DKRDTSNFDK EFTRQPVELT PTDKLFIMNL DQNEFAGFSY  60
   61 TNPEFVINV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.0
Match: 2i0eA
Description: No description for 2i0eA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle