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Protein Overview: PRKCB1

General Information:
Name(s) found: PRKCB1 [HGNC (HUGO)]
Description(s) found:
Found 33 descriptions.
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  • protein kinase C, beta 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 671 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF  60
   61 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS 120
  121 LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR DVLIVLVRDA 180
  181 KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL 240
  241 SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE 300
  301 LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE 360
  361 RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM 420
  421 EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI 480
  481 KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP 540
  541 FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF 600
  601 RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM NLDQNEFAGF 660
  661 SYTNPEFVIN V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 7.69897 Crystal Structure of the Human Beta2-Chimaerin
    2 View Details [94..179] FFAS03 3.12 NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
    3 View Details [180..602] PSI-BLAST 65.39794 Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
    4 View Details [603..671] PSI-BLAST 88.0 No description for 2i0eA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.71782887289779 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86705824967236 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91441035614579 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.62921423829738 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • transcription factor activity
    		•  1.39657429296564 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.10685156896266 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • cation binding
    		•  0.416345209135028 bayes_pls_golite062009
  • metal ion binding
    		•  0.416345209135028 bayes_pls_golite062009
  • ion binding
    		•  0.411417584934096 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.362457326055781 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.46734661087649 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.82097223032126 bayes_pls_golite062009
  • binding
    		•  2.71288992341677 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.43859890356027 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.42148330229896 bayes_pls_golite062009
  • protein binding
    		•  2.2604757016607 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.07238897772131 bayes_pls_golite062009
  • DNA binding
    		•  2.05972958088217 bayes_pls_golite062009
  • kinase activity
    		•  2.00903309297046 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91592331431516 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.83466699022067 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.78173505822139 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  1.76217210688028 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.73820712435638 bayes_pls_golite062009
  • protein kinase activity
    		•  1.61903873760762 bayes_pls_golite062009
  • transferase activity
    		•  1.45394179515146 bayes_pls_golite062009
  • transcription factor activity
    		•  1.38590948364516 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25050856744516 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25050856744516 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.969266093401353 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.93378879973188 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.854618067843974 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.716569837044966 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.531562206762648 bayes_pls_golite062009
  • kinase binding
    		•  0.409606963040614 bayes_pls_golite062009
  • cation binding
    		•  0.311967762495891 bayes_pls_golite062009
  • metal ion binding
    		•  0.311967762495891 bayes_pls_golite062009
  • ion binding
    		•  0.307697800147455 bayes_pls_golite062009
  • catalytic activity
    		•  0.216721136299042 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.160536263083511 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.03401803018883 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  2.31137729067208 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • telethonin binding
    		•  2.27062712605521 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • GTPase activity
    		•  2.07905155389729 bayes_pls_golite062009
  • insulin binding
    		•  2.0719180171079 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • PTB domain binding
    		•  1.96099803532698 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.94085498993561 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.74206248731815 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  1.5013287968167 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  1.43713739644553 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • alpha-actinin binding
    		•  1.38861866085902 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.24312972088703 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.2266791546014 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.19908793854422 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • structural molecule activity
    		•  1.10436308210353 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.889321498544699 bayes_pls_golite062009
  • transcription activator activity
    		•  0.846644791435606 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • vinculin binding
    		•  0.666656406096231 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.63080698970012 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.585036697436369 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.547121592096699 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • photoreceptor activity
    		•  0.187612589250841 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • cation binding
    		•  0.046173055856133 bayes_pls_golite062009
  • metal ion binding
    		•  0.046173055856133 bayes_pls_golite062009
  • ion binding
    		•  0.0389662058697694 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.0386657159233388 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle