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View Structure Prediction Details

Protein: CDC42
Organism: Saccharomyces cerevisiae
Length: 191 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC42.

Description E-value Query
Range
Subject
Range
RAC1_CANLF - Ras-related C3 botulinum toxin substrate 1 OS=Canis lupus familiaris GN=RAC1 PE=2 SV=1
RAC1 - ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
gi|90085276 - gi|90085276|dbj|BAE91379.1| unnamed protein product [Macaca fascicularis]
gi|117616674, gi... - gi|208967264|dbj|BAG73646.1| ras-related C3 botulinum toxin substrate 1 [synthetic construct], gi|19...
gi|149636782 - gi|149636782|ref|XP_001506443.1| PREDICTED: similar to Chain B, Activated Rac1 Bound To Its Effector...
RAC1_MOUSE - Ras-related C3 botulinum toxin substrate 1 OS=Mus musculus GN=Rac1 PE=1 SV=1
RAC1_BOVIN - Ras-related C3 botulinum toxin substrate 1 OS=Bos taurus GN=RAC1 PE=1 SV=1
gi|3184510, gi|4... - gi|45384330|ref|NP_990348.1| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP bindi...
RAC1_RAT - Ras-related C3 botulinum toxin substrate 1 OS=Rattus norvegicus GN=Rac1 PE=1 SV=1
gi|89272838, gi|... - gi|89272838|emb|CAJ83626.1| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP bindin...
ENSPTRT00000034946 - null
gi|238566849, gi... - gi|240849265|ref|NP_001155328.1| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP b...
2.0E-91 [1..191] [1..192]
gi|5738220, gi|8... - gi|80476985|gb|AAI08885.1| RAC1 protein [Xenopus laevis], gi|5738220|gb|AAD50299.1|AF174644_1 rac GT...
4.0E-91 [1..191] [1..192]
gi|12842616 - gi|12842616|dbj|BAB25667.1| unnamed protein product [Mus musculus]
5.0E-91 [1..191] [1..192]
gi|190652897, gi... - gi|194864801|ref|XP_001971114.1| GG14611 [Drosophila erecta], gi|190652897|gb|EDV50140.1| GG14611 [D...
gi|194127983, gi... - gi|195336533|ref|XP_002034890.1| GM14225 [Drosophila sechellia], gi|194127983|gb|EDW50026.1| GM14225...
gi|193919244, gi... - gi|195126353|ref|XP_002007635.1| GI12273 [Drosophila mojavensis], gi|193919244|gb|EDW18111.1| GI1227...
FBpp0304252, Rac1-PA - The gene Rac1 is referred to in FlyBase by the symbol Dmel\Rac1 (CG2248, FBgn0010333). It is a prote...
gi|195490349, gi... - gi|195490349|ref|XP_002093102.1| GE20972 [Drosophila yakuba], gi|194179203|gb|EDW92814.1| GE20972 [D...
gi|195376515, gi... - gi|195376515|ref|XP_002047042.1| GJ13209 [Drosophila virilis], gi|194154200|gb|EDW69384.1| GJ13209 [...
gi|220955768, gi... - gi|220955768|gb|ACL90427.1| Rac1-PA [synthetic construct], gi|220946018|gb|ACL85552.1| Rac1-PA [synt...
gi|195586881, gi... - gi|195586881|ref|XP_002083196.1| GD13487 [Drosophila simulans], gi|194195205|gb|EDX08781.1| GD13487 ...
gi|54641203|gb|E... - GA15321-PA [Drosophila pseudoobscura], GA15321 [Drosophila pseudoobscura pseudoobscura]
gi|125976848, gi... - gi|54641203|gb|EAL29953.1| GA15321 [Drosophila pseudoobscura pseudoobscura], gi|125976848|ref|XP_001...
1.0E-88 [1..191] [1..192]
gi|60470127, gi|... - gi|66816373|ref|XP_642196.1| Rho GTPase [Dictyostelium discoideum AX4], gi|60470127|gb|EAL68107.1| R...
RAC1A_DICDI - Rho-related protein rac1A OS=Dictyostelium discoideum GN=rac1A PE=1 SV=2
1.0E-88 [1..191] [1..194]

Back

Predicted Domain #1
Region A:
Residues: [1-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTLKCVVVG DGAVGKTCLL ISYTTNQFPA DYVPTVFDNY AVTVMIGDEP YTLGLFDTAG  60
   61 QEDYDRLRPL SYPSTDVFLV CFSVISPPSF ENVKEKWFPE VHHHCPGVPC LVVGTQIDLR 120
  121 DDKVIIEKLQ RQRLRPITSE QGSRLARELK AVKYVECSAL TQRGLKNVFD EAIVAALEPP 180
  181 VIKKSKKCAI L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 940.201249
Match: 1grnA_
Description: CDC42
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.26230696590213 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
microtubule motor activity 3.91769993918004 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.35170865169069 bayes_pls_golite062009
actin binding 3.33639699088484 bayes_pls_golite062009
microfilament motor activity 3.17800963620802 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
structural constituent of ribosome 3.070470376968 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
hydrolase activity 2.73675310079844 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
G-protein coupled receptor activity 2.3505608190884 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
actin filament binding 2.24723363507804 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
structural molecule activity 2.08211451183607 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 1.95782378818812 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
1.86855842486607 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
structural constituent of muscle 1.75982319871463 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
actin-dependent ATPase activity 1.58897222423517 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
GDP-dissociation inhibitor binding 1.53046363842187 bayes_pls_golite062009
apolipoprotein receptor activity 1.52496551152043 bayes_pls_golite062009
syntaxin-13 binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.52496551152043 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
transmembrane receptor activity 1.26314334516725 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
receptor activity 1.20313362488821 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
ADP binding 1.10601354993582 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
GBD domain binding 0.914270985726459 bayes_pls_golite062009
peptide-transporting ATPase activity 0.911425383309011 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
peptide transporter activity 0.73541731084591 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
potassium channel activity 0.694411056320469 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 0.621822998821133 bayes_pls_golite062009
cell surface binding 0.618263399939881 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
nucleotide kinase activity 0.56979593127581 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.567883621045161 bayes_pls_golite062009
beta-catenin binding 0.567325521781475 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
signal sequence binding 0.42240724331108 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.328170855722634 bayes_pls_golite062009
peptide binding 0.304703625340488 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
myosin binding 0.274885859454447 bayes_pls_golite062009
voltage-gated calcium channel activity 0.25979628626254 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
minus-end directed microfilament motor activity 0.103268955687259 bayes_pls_golite062009
RNA binding 0.0693163519626152 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

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