YRC Public Data Repository - Protein Structure Prediction

Protein:	BPT1
Organism:	Saccharomyces cerevisiae
Length:	1559 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BPT1.

Description	E-value	Query Range	Subject Range
gi\|3242460, gi\|1... - gi\|3242460\|dbj\|BAA28955.1\| multidrug resistance-associated protein (MRP)-like protein-2 (MLP-2) [Rat...	0.0	[15..1557]	[18..1522]
gi\|4204793 - gi\|4204793\|gb\|AAD10836.1\| P-glycoprotein [Solanum tuberosum]	0.0	[259..1557]	[37..1290]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[16..1557]	[13..1526]
BPT1_YEAST - Bile pigment transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BPT1 PE=1 SV=... BPT1 - ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the t...	0.0	[1..1559]	[1..1559]
gi\|4102188 - gi\|4102188\|gb\|AAD01430.1\| MRP3 [Homo sapiens]	0.0	[16..1557]	[13..1527]
MDR3_MOUSE - Multidrug resistance protein 3 OS=Mus musculus GN=Abcb1a PE=2 SV=2	0.0	[244..1556]	[3..1271]
AB7B_ARATH - ABC transporter B family member 7 OS=Arabidopsis thaliana GN=ABCB7 PE=3 SV=1	0.0	[266..1552]	[3..1241]

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Predicted Domain #1

Region A:
Residues: [1-241]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLEVVDGC PYGYRPYPDS GTNALNPCFI SVISAWQAVF FLLIGSYQLW KLYKNNKVPP  60
   61 RFKNFPTLPS KINSRHLTHL TNVCFQSTLI ICELALVSQS SDRVYPFILK KALYLNLLFN 120
  121 LGISLPTQYL AYFKSTFSMG NQLFYYMFQI LLQLFLILQR YYHGSSNERL TVISGQTAMI 180
  181 LEVLLLFNSV AIFIYDLCIF EPINELSEYY KKNGWYPPVH VLSYITFIWM NKLIVETYRN 240
  241 K

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [242-625]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKDPNQLPL PPVDLNIKSI SKEFKANWEL EKWLNRNSLW RAIWKSFGRT ISVAMLYETT  60
   61 SDLLSVVQPQ FLRIFIDGLN PETSSKYPPL NGVFIALTLF VISVVSVFLT NQFYIGIFEA 120
  121 GLGIRGSLAS LVYQKSLRLT LAERNEKSTG DILNLMSVDV LRIQRFFENA QTIIGAPIQI 180
  181 IVVLTSLYWL LGKAVIGGLV TMAIMMPINA FLSRKVKKLS KTQMKYKDMR IKTITELLNA 240
  241 IKSIKLYAWE EPMMARLNHV RNDMELKNFR KIGIVSNLIY FAWNCVPLMV TCSTFGLFSL 300
  301 FSDSPLSPAI VFPSLSLFNI LNSAIYSVPS MINTIIETSV SMERLKSFLL SDEIDDSFIE 360
  361 RIDPSADERA LPAIEMNNIT FLWK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.42
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [626-892]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEVLTSSQS GDNLRTDEES IIGSSQIALK NIDHFEAKRG DLVCVVGRVG AGKSTFLKAI  60
   61 LGQLPCMSGS RDSIPPKLII RSSSVAYCSQ ESWIMNASVR ENILFGHKFD QDYYDLTIKA 120
  121 CQLLPDLKIL PDGDETLVGE KGISLSGGQK ARLSLARAVY SRADIYLLDD ILSAVDAEVS 180
  181 KNIIEYVLIG KTALLKNKTI ILTTNTVSIL KHSQMIYALE NGEIVEQGNY EDVMNRKNNT 240
  241 SKLKKLLEEF DSPIDNGNES DVQTEHR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	407.09691
Match:	1nbd__
Description:	No description for 1nbd__ was found.

Predicted functions:

Term	Confidence	Notes
lipid transporter activity	6.95325922226092	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	5.4467861893359	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	5.44654566127945	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	5.44654566127945	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	5.43909190876515	bayes_pls_golite062009
primary active transmembrane transporter activity	5.4304944906989	bayes_pls_golite062009
active transmembrane transporter activity	5.38112407181712	bayes_pls_golite062009
ATPase activity, coupled	4.87869064889244	bayes_pls_golite062009
ATPase activity	4.60773943958528	bayes_pls_golite062009
nucleoside-triphosphatase activity	4.38591214726007	bayes_pls_golite062009
pyrophosphatase activity	4.32673473878039	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	4.31087891816858	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.31037981322306	bayes_pls_golite062009
hydrolase activity	4.09315408758191	bayes_pls_golite062009
transporter activity	3.47953169973151	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.96171085039592	bayes_pls_golite062009
transmembrane transporter activity	2.94175800357966	bayes_pls_golite062009
substrate-specific transporter activity	2.90743799425416	bayes_pls_golite062009
ATP binding	2.83986218503994	bayes_pls_golite062009
adenyl ribonucleotide binding	2.79195527951815	bayes_pls_golite062009
adenyl nucleotide binding	2.74359323245512	bayes_pls_golite062009
purine ribonucleotide binding	2.55506944753783	bayes_pls_golite062009
ribonucleotide binding	2.55426312645972	bayes_pls_golite062009
purine nucleotide binding	2.51344800975739	bayes_pls_golite062009
nucleotide binding	2.48057252852174	bayes_pls_golite062009
binding	1.81483350844459	bayes_pls_golite062009
catalytic activity	0.372934161904337	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [893-955]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESEVDEPLQ LKVTESETED EVVTESELEL IKANSRRASL ATLRPRPFVG AQLDSVKKTA  60
   61 QKA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [956-1061]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKTEVGRVKT KIYLAYIKAC GVLGVVLFFL FMILTRVFDL AENFWLKYWS ESNEKNGSNE  60
   61 RVWMFVGVYS LIGVASAAFN NLRSIMMLLY CSIRGSKKLH ESMAKS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1080-1278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRFSSDMDAV DSNLQYIFSF FFKSILTYLV TVILVGYNMP WFLVFNMFLV VIYIYYQTFY  60
   61 IVLSRELKRL ISISYSPIMS LMSESLNGYS IIDAYDHFER FIYLNYEKIQ YNVDFVFNFR 120
  121 STNRWLSVRL QTIGATIVLA TAILALATMN TKRQLSSGMV GLLMSYSLEV TGSLTWIVRT 180
  181 TVTIETNIVS VERIVEYCE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	519.218487
Match:	1jsqA_
Description:	MsbA
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [1062-1079]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIRSPMTFFE TTPVGRII

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1279-1559]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPEAQSINP EKRPDENWPS KGGIEFKNYS TKYRENLDPV LNNINVKIEP CEKVGIVGRT  60
   61 GAGKSTLSLA LFRILEPTEG KIIIDGIDIS DIGLFDLRSH LAIIPQDAQA FEGTVKTNLD 120
  121 PFNRYSEDEL KRAVEQAHLK PHLEKMLHSK PRGDDSNEED GNVNDILDVK INENGSNLSV 180
  181 GQRQLLCLAR ALLNRSKILV LDEATASVDM ETDKIIQDTI RREFKDRTIL TIAHRIDTVL 240
  241 DSDKIIVLDQ GSVREFDSPS KLLSDKTSIF YSLCEKGGYL K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	519.218487
Match:	1jsqA_
Description:	MsbA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lipid transporter activity	7.47642599298853	bayes_pls_golite062009
metal ion transmembrane transporter activity	6.80339337010085	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	5.57844095962502	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	5.57813579764186	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	5.57813579764186	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	5.5689620139321	bayes_pls_golite062009
primary active transmembrane transporter activity	5.55992639965745	bayes_pls_golite062009
active transmembrane transporter activity	5.50005167063544	bayes_pls_golite062009
cation channel activity	5.46287131955314	bayes_pls_golite062009
voltage-gated cation channel activity	5.29074477899638	bayes_pls_golite062009
voltage-gated ion channel activity	5.1184221202951	bayes_pls_golite062009
potassium channel activity	5.11125652739479	bayes_pls_golite062009
voltage-gated channel activity	5.10064970232011	bayes_pls_golite062009
ATPase activity, coupled	4.98276715440477	bayes_pls_golite062009
ion channel activity	4.87468443062464	bayes_pls_golite062009
channel activity	4.74517495695421	bayes_pls_golite062009
passive transmembrane transporter activity	4.74517495695421	bayes_pls_golite062009
peptide transporter activity	4.7442815698413	bayes_pls_golite062009
substrate-specific channel activity	4.71152823189573	bayes_pls_golite062009
ATPase activity	4.69795387297193	bayes_pls_golite062009
peptide-transporting ATPase activity	4.63590351019108	bayes_pls_golite062009
cadmium ion transmembrane transporter activity	4.62439240790153	bayes_pls_golite062009
gated channel activity	4.61941650351493	bayes_pls_golite062009
structural constituent of ribosome	4.56509805974548	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	4.45975815173802	bayes_pls_golite062009
nucleoside-triphosphatase activity	4.45923622153365	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	4.44979714930206	bayes_pls_golite062009
pyrophosphatase activity	4.39781350157199	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	4.38133275795019	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.38085303582726	bayes_pls_golite062009
sulfonylurea receptor activity	4.29224907929661	bayes_pls_golite062009
bilirubin transmembrane transporter activity	4.16465937144981	bayes_pls_golite062009
hydrolase activity	4.12107348093071	bayes_pls_golite062009
oligopeptide-transporting ATPase activity	4.09365342567844	bayes_pls_golite062009
transporter activity	3.71239480053329	bayes_pls_golite062009
structural molecule activity	3.58406348799895	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	3.16975154423199	bayes_pls_golite062009
transmembrane transporter activity	3.13960906549884	bayes_pls_golite062009
anion transmembrane transporter activity	3.13913638619234	bayes_pls_golite062009
substrate-specific transporter activity	3.1318898376276	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
ATP binding	3.01346604299372	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.00745742755195	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
adenyl ribonucleotide binding	2.96271391116269	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.9271291809464	bayes_pls_golite062009
adenyl nucleotide binding	2.91131545957759	bayes_pls_golite062009
ligand-gated ion channel activity	2.77610331510393	bayes_pls_golite062009
ligand-gated channel activity	2.77610331510393	bayes_pls_golite062009
purine ribonucleotide binding	2.70262534541085	bayes_pls_golite062009
ribonucleotide binding	2.70178191749524	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
purine nucleotide binding	2.6583477492092	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.63419811368692	bayes_pls_golite062009
nucleotide binding	2.62374702628143	bayes_pls_golite062009
sterol transporter activity	2.48473697371886	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity	2.33958437214304	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
structural constituent of muscle	2.27871582090443	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
iron ion transmembrane transporter activity	2.14305203987289	bayes_pls_golite062009
motor activity	2.11140484670646	bayes_pls_golite062009
oligopeptide transporter activity	2.05580564974083	bayes_pls_golite062009
voltage-gated calcium channel activity	1.96314034513078	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	1.85247645478102	bayes_pls_golite062009
binding	1.84115074893083	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
cytoskeletal protein binding	1.7703386719161	bayes_pls_golite062009
organic anion transmembrane transporter activity	1.76999970080179	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
nucleic acid binding	1.52921795164482	bayes_pls_golite062009
actin binding	1.42666717383185	bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity	1.37836402136387	bayes_pls_golite062009
glutathione transmembrane transporter activity	1.35514937365621	bayes_pls_golite062009
sphingolipid transporter activity	1.35514937365621	bayes_pls_golite062009
microfilament motor activity	1.33993901826495	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
DNA binding	1.19966224604123	bayes_pls_golite062009
peptidase activity	1.12876670227791	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	1.1043570439403	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	1.1043570439403	bayes_pls_golite062009
nucleotide kinase activity	1.10251779925246	bayes_pls_golite062009
transcription regulator activity	1.09075553688438	bayes_pls_golite062009
protein transporter activity	1.05248757342537	bayes_pls_golite062009
phosphonate transmembrane transporter activity	1.01407208402176	bayes_pls_golite062009
dipeptide transporter activity	1.01130176523309	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	0.955327639402151	bayes_pls_golite062009
signal transducer activity	0.952448314982579	bayes_pls_golite062009
molecular transducer activity	0.952448314982579	bayes_pls_golite062009
	0.869999622006359	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
signal recognition particle binding	0.834762947727611	bayes_pls_golite062009
copper ion transmembrane transporter activity	0.798934081014025	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.765442336337003	bayes_pls_golite062009
phospholipid transporter activity	0.755445322666929	bayes_pls_golite062009
glutathione S-conjugate-exporting ATPase activity	0.719430645205088	bayes_pls_golite062009
bile acid transmembrane transporter activity	0.687612064139871	bayes_pls_golite062009
phosphate transmembrane transporter activity	0.67748815522005	bayes_pls_golite062009
high voltage-gated calcium channel activity	0.64930610472341	bayes_pls_golite062009
cholesterol transporter activity	0.644421039250979	bayes_pls_golite062009
long-chain fatty acid transporter activity	0.445784480190949	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
actin filament binding	0.437646833557392	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.40217318916177	bayes_pls_golite062009
catalytic activity	0.368034275052766	bayes_pls_golite062009
microtubule motor activity	0.32730260506261	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
receptor activity	0.277332279568238	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
fatty acid transporter activity	0.251070374183928	bayes_pls_golite062009
transmembrane receptor activity	0.243026482777117	bayes_pls_golite062009
RNA helicase activity	0.2302541318658	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.219473333671469	bayes_pls_golite062009
apolipoprotein receptor activity	0.201503131198139	bayes_pls_golite062009
syntaxin-13 binding	0.201503131198139	bayes_pls_golite062009
apolipoprotein A-I binding	0.201503131198139	bayes_pls_golite062009
apolipoprotein A-I receptor activity	0.201503131198139	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.175442402308287	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
RNA binding	0.0693163519626152	bayes_pls_golite062009
transcription factor activity	0.0612932659603008	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: