YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classifier used Gene Ontology annotations. [FDR: 0.02] [SVM Score: 1.12173414725]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
SIR3
  • nuclear telomeric heterochromatin
  • mitochondrion
  • nucleolus
  • chromatin silencing complex
  • nuclear telomere cap complex
    		•
  • loss of chromatin silencing involved in replicative cell aging
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
    		•
  • structural constituent of chromatin
  • histone binding
    		•
    SIR4
  • nuclear telomeric heterochromatin
  • chromatin silencing complex
  • nuclear telomere cap complex
    		•
  • loss of chromatin silencing involved in replicative cell aging
  • telomere maintenance
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
    		•
  • structural constituent of chromatin
  • histone binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear telomeric heterochromatin 1.0611E-6 2 7 2 6292
    telomeric heterochromatin 1.0611E-6 2 7 2 6292
    nuclear heterochromatin 1.0611E-6 2 7 2 6292
    heterochromatin 1.0611E-6 2 7 2 6292
    chromatin silencing complex 1.819E-6 2 9 2 6292
    telomere cap complex 2.779E-6 2 11 2 6292
    nuclear telomere cap complex 2.779E-6 2 11 2 6292
    nuclear chromosome, telomeric region 1.2783E-5 2 23 2 6292
    chromosome, telomeric region 1.7735E-5 2 27 2 6292
    protein-DNA complex 8.0641E-5 2 57 2 6292
    nuclear chromatin 1.3278E-4 2 73 2 6292
    chromatin 1.4784E-4 2 77 2 6292
    chromatin remodeling complex 2.4511E-4 2 99 2 6292
    nuclear chromosome part 9.0721E-4 2 190 2 6292
    nuclear chromosome 1.3075E-3 2 228 2 6292
    chromosomal part 1.413E-3 2 237 2 6292
    chromosome 1.8898E-3 2 274 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    loss of chromatin silencing involved in replicative cell aging 1.819E-6 2 9 2 6292
    progressive alteration of chromatin involved in replicative cell aging 2.2737E-6 2 10 2 6292
    loss of chromatin silencing 2.2737E-6 2 10 2 6292
    progressive alteration of chromatin involved in cell aging 2.779E-6 2 11 2 6292
    positive regulation of gene expression, epigenetic 2.779E-6 2 11 2 6292
    regulation of gene silencing 2.779E-6 2 11 2 6292
    negative regulation of gene silencing 2.779E-6 2 11 2 6292
    regulation of chromatin silencing 2.779E-6 2 11 2 6292
    negative regulation of chromatin silencing 2.779E-6 2 11 2 6292
    double-strand break repair via nonhomologous end joining 1.5158E-5 2 25 2 6292
    non-recombinational repair 2.8346E-5 2 34 2 6292
    replicative cell aging 3.552E-5 2 38 2 6292
    cell aging 5.9419E-5 2 49 2 6292
    aging 6.4422E-5 2 51 2 6292
    double-strand break repair 8.0641E-5 2 57 2 6292
    negative regulation of gene expression, epigenetic 2.5011E-4 2 100 2 6292
    gene silencing 2.5011E-4 2 100 2 6292
    regulation of gene expression, epigenetic 2.5011E-4 2 100 2 6292
    chromatin silencing 2.5011E-4 2 100 2 6292
    positive regulation of transcription, DNA-dependent 2.6542E-4 2 103 2 6292
    positive regulation of RNA metabolic process 2.8654E-4 2 107 2 6292
    positive regulation of transcription 3.1407E-4 2 112 2 6292
    positive regulation of gene expression 3.1407E-4 2 112 2 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.4879E-4 2 118 2 6292
    positive regulation of nitrogen compound metabolic process 3.4879E-4 2 118 2 6292
    positive regulation of macromolecule biosynthetic process 3.4879E-4 2 118 2 6292
    positive regulation of biosynthetic process 3.6682E-4 2 121 2 6292
    positive regulation of cellular biosynthetic process 3.6682E-4 2 121 2 6292
    positive regulation of macromolecule metabolic process 3.979E-4 2 126 2 6292
    positive regulation of metabolic process 4.1715E-4 2 129 2 6292
    positive regulation of cellular metabolic process 4.1715E-4 2 129 2 6292
    positive regulation of cellular process 4.6384E-4 2 136 2 6292
    positive regulation of biological process 4.7071E-4 2 137 2 6292
    negative regulation of transcription, DNA-dependent 6.1875E-4 2 157 2 6292
    negative regulation of RNA metabolic process 6.2668E-4 2 158 2 6292
    negative regulation of transcription 6.7534E-4 2 164 2 6292
    negative regulation of gene expression 6.7534E-4 2 164 2 6292
    chromatin modification 7.0879E-4 2 168 2 6292
    negative regulation of macromolecule biosynthetic process 7.6927E-4 2 175 2 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.1399E-4 2 180 2 6292
    negative regulation of nitrogen compound metabolic process 8.1399E-4 2 180 2 6292
    negative regulation of biosynthetic process 8.9766E-4 2 189 2 6292
    negative regulation of cellular biosynthetic process 8.9766E-4 2 189 2 6292
    DNA repair 9.2646E-4 2 192 2 6292
    negative regulation of macromolecule metabolic process 9.2646E-4 2 192 2 6292
    chromatin organization 1.036E-3 2 203 2 6292
    negative regulation of cellular metabolic process 1.0983E-3 2 209 2 6292
    negative regulation of metabolic process 1.1088E-3 2 210 2 6292
    response to DNA damage stimulus 1.4011E-3 2 236 2 6292
    negative regulation of cellular process 1.5726E-3 2 250 2 6292
    negative regulation of biological process 1.6107E-3 2 253 2 6292
    cellular response to stress 2.1173E-3 2 290 2 6292
    developmental process 2.7595E-3 2 331 2 6292
    regulation of transcription, DNA-dependent 3.2288E-3 2 358 2 6292
    regulation of RNA metabolic process 3.3198E-3 2 363 2 6292
    cellular response to stimulus 3.6193E-3 2 379 2 6292
    regulation of transcription 3.7155E-3 2 384 2 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.3405E-3 2 415 2 6292
    regulation of nitrogen compound metabolic process 4.3615E-3 2 416 2 6292
    regulation of gene expression 4.9915E-3 2 445 2 6292
    regulation of macromolecule biosynthetic process 5.2416E-3 2 456 2 6292
    regulation of cellular biosynthetic process 5.6164E-3 2 472 2 6292
    regulation of biosynthetic process 5.6402E-3 2 473 2 6292
    regulation of macromolecule metabolic process 6.004E-3 2 488 2 6292
    response to stress 6.2277E-3 2 497 2 6292
    transcription, DNA-dependent 6.3792E-3 2 503 2 6292
    RNA biosynthetic process 6.5067E-3 2 508 2 6292
    regulation of primary metabolic process 6.6615E-3 2 514 2 6292
    regulation of cellular metabolic process 7.2445E-3 2 536 2 6292
    regulation of metabolic process 7.5452E-3 2 547 2 6292
    transcription 7.6839E-3 2 552 2 6292
    chromosome organization 7.7677E-3 2 555 2 6292
    DNA metabolic process 8.631E-3 2 585 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    structural constituent of chromatin 5.0527E-8 2 2 2 6292
    histone binding 4.5979E-6 2 14 2 6292
    structural molecule activity 2.8947E-3 2 339 2 6292
    protein binding 9.4468E-3 2 612 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle