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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sec27. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BTN2
  • late endosome
  • cytosol
  • intracellular protein transport
  • retrograde transport, endosome to Golgi
  • amino acid transport
  • regulation of pH
  • protein binding
  • CCT2
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT6
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • COP1
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • CTR1
  • plasma membrane
  • copper ion import
  • copper uptake transmembrane transporter activity
  • DHH1
  • cytoplasm
  • cytoplasmic mRNA processing body
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • protein binding
  • RNA helicase activity
  • EAP1
  • mRNA cap binding complex
  • response to drug
  • telomere maintenance
  • negative regulation of translation
  • eukaryotic initiation factor 4E binding
  • GAL7
  • cytoplasm
  • galactose catabolic process
  • UTP:galactose-1-phosphate uridylyltransferase activity
  • GDT1
  • fungal-type vacuole
  • biological_process
  • molecular_function
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • MEH1
  • late endosome membrane
  • fungal-type vacuole membrane
  • vacuolar acidification
  • microautophagy
  • molecular_function
  • PRB1
  • fungal-type vacuole lumen
  • fungal-type vacuole
  • cellular response to starvation
  • sporulation resulting in formation of a cellular spore
  • vacuolar protein catabolic process
  • serine-type endopeptidase activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SEC28
  • endosome
  • COPI vesicle coat
  • vesicle coating
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • TCP1
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • YCR076C
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    COPI coated vesicle membrane 1.9392E-6 19 9 3 6292
    COPI vesicle coat 1.9392E-6 19 9 3 6292
    chaperonin-containing T-complex 5.0498E-6 19 12 3 6292
    Golgi-associated vesicle membrane 1.2756E-5 19 16 3 6292
    COPI-coated vesicle 3.0008E-5 19 21 3 6292
    vesicle coat 1.317E-4 19 34 3 6292
    coated vesicle membrane 1.4377E-4 19 35 3 6292
    cytoplasmic vesicle membrane 1.4377E-4 19 35 3 6292
    vesicle membrane 1.4377E-4 19 35 3 6292
    membrane coat 1.8426E-4 19 38 3 6292
    coated membrane 1.8426E-4 19 38 3 6292
    cytoplasmic vesicle part 1.9923E-4 19 39 3 6292
    Golgi-associated vesicle 2.1497E-4 19 40 3 6292
    Golgi membrane 3.9405E-4 19 49 3 6292
    coated vesicle 1.8416E-3 19 83 3 6292
    late endosome 1.9252E-3 19 22 2 6292
    proteasome regulatory particle 2.1048E-3 19 23 2 6292
    proteasome accessory complex 2.1048E-3 19 23 2 6292
    endosome 2.6308E-3 19 94 3 6292
    protein complex 3.2286E-3 19 1137 9 6292
    membrane-bounded vesicle 3.8001E-3 19 107 3 6292
    cytoplasmic vesicle 3.8001E-3 19 107 3 6292
    cytoplasmic membrane-bounded vesicle 3.8001E-3 19 107 3 6292
    vesicle 4.1084E-3 19 110 3 6292
    Golgi apparatus part 5.1237E-3 19 119 3 6292
    cytosolic part 5.493E-3 19 122 3 6292
    proteasome complex 8.972E-3 19 48 2 6292
    mRNA cap binding complex 9.0332E-3 19 3 1 6292
    cytosol 9.2018E-3 19 284 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein folding 7.3552E-5 19 78 4 6292
    catabolic process 3.9532E-4 19 496 7 6292
    cellular catabolic process 1.0295E-3 19 415 6 6292
    ER to Golgi vesicle-mediated transport 1.8416E-3 19 83 3 6292
    retrograde vesicle-mediated transport, Golgi to ER 2.6892E-3 19 26 2 6292
    regulation of pH 3.3414E-3 19 29 2 6292
    monovalent inorganic cation homeostasis 5.6929E-3 19 38 2 6292
    cellular macromolecule catabolic process 7.2256E-3 19 265 4 6292
    cellular protein metabolic process 9.0272E-3 19 1074 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    unfolded protein binding 7.523E-4 19 61 3 6292
    protein binding 1.4116E-3 19 612 7 6292
    chaperone inhibitor activity 3.0197E-3 19 1 1 6292
    UTP:galactose-1-phosphate uridylyltransferase activity 3.0197E-3 19 1 1 6292
    eukaryotic initiation factor 4E binding 3.0197E-3 19 1 1 6292
    translation initiation factor binding 3.0197E-3 19 1 1 6292
    Hsp70 protein binding 6.0308E-3 19 2 1 6292
    UTP-monosaccharide-1-phosphate uridylyltransferase activity 6.0308E-3 19 2 1 6292
    isocitrate dehydrogenase (NAD+) activity 6.0308E-3 19 2 1 6292
    Hsp90 protein binding 6.0308E-3 19 2 1 6292
    chaperone activator activity 9.0332E-3 19 3 1 6292
    uridylyltransferase activity 9.0332E-3 19 3 1 6292
    heat shock protein binding 9.0332E-3 19 3 1 6292
    copper uptake transmembrane transporter activity 9.0332E-3 19 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle