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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. Any process that decreases the ability of the translational apparatus to interpret the genetic code. Any process that stops, prevents or reduces the frequency, rate or extent of translational termination. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation. The process in which a symbiont organism activates or increases the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of translation
Acc: GO:0017148
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
Synonyms:
  • downregulation of protein biosynthetic process
  • negative regulation of protein formation
  • down regulation of protein biosynthetic process
  • negative regulation of protein biosynthesis
  • down-regulation of protein biosynthetic process
  • negative regulation of protein synthesis
  • negative regulation of protein biosynthetic process
  • protein biosynthesis inhibitor activity
  • negative regulation of protein anabolism
  • protein biosynthetic process inhibitor activity
  • GO:0016478
  • inhibition of protein biosynthetic process
Proteins in PDR annotated with:
   This term: 86 [Search]
   Term or descendants: 154 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0017148 - negative regulation of translation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle