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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes: From the published set of protein complexes.
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BNI1
  • polarisome
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • mating projection tip
  • actin filament
  • actin cap
    		•
  • intracellular mRNA localization
  • bipolar cellular bud site selection
  • regulation of initiation of mating projection growth
  • response to osmotic stress
  • pseudohyphal growth
  • actin filament organization
  • Rho protein signal transduction
  • budding cell bud growth
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • gene conversion at mating-type locus
  • establishment of mitotic spindle orientation
  • filamentous growth
  • actin nucleation
  • regulation of termination of mating projection growth
    		•
  • cytoskeletal regulatory protein binding
    		•
    CDC48
  • endoplasmic reticulum membrane
  • nucleus
  • microsome
  • cytosol
    		•
  • vesicle fusion
  • apoptosis
  • protein transport
  • ER-associated protein catabolic process
  • cell cycle
  • ubiquitin-dependent protein catabolic process
    		•
  • ATPase activity
    		•
    DOA1
  • nucleus
  • cytoplasm
    		•
  • double-strand break repair via nonhomologous end joining
  • ubiquitin cycle
  • ubiquitin-dependent protein catabolic process
    		•
  • ubiquitin binding
    		•
    MRPS28
  • mitochondrion
  • mitochondrial small ribosomal subunit
    		•
  • ribosomal small subunit assembly
  • translation
    		•
  • RNA binding
  • structural constituent of ribosome
    		•
    NPL4
  • nuclear membrane-endoplasmic reticulum network
  • endoplasmic reticulum
    		•
  • ER-associated protein catabolic process
    		•
  • molecular_function
    		•
    PDC1
  • nucleus
  • cytoplasm
  • cytosol
    		•
  • pyruvate metabolic process
  • glucose catabolic process to ethanol
    		•
  • pyruvate decarboxylase activity
    		•
    RAI1
  • nucleus
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • processing of 27S pre-rRNA
    		•
  • enzyme regulator activity
    		•
    REG1
  • protein phosphatase type 1 complex
  • cytoplasm
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • regulation of carbohydrate metabolic process
  • glycogen metabolic process
  • vacuolar protein catabolic process
    		•
  • protein phosphatase type 1 regulator activity
    		•
    RPA135
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA190
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO31
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    SHP1
  • nucleus
  • cytoplasm
    		•
  • ascospore formation
  • proteasomal ubiquitin-dependent protein catabolic process
  • glycogen metabolic process
  • telomere maintenance
    		•
  • protein phosphatase type 1 regulator activity
    		•
    UFD1
  • endoplasmic reticulum
    		•
  • protein transport
  • mRNA processing
  • ubiquitin-dependent protein catabolic process
    		•
  • protein binding
    		•
    YDR049W
  • cytoplasm
  • mitochondrion
    		•
  • biological_process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA-directed RNA polymerase complex 3.8006E-5 14 31 3 6292
    RNA polymerase complex 3.8006E-5 14 31 3 6292
    nuclear DNA-directed RNA polymerase complex 3.8006E-5 14 31 3 6292
    DNA-directed RNA polymerase I complex 4.1207E-4 14 14 2 6292
    nucleolar part 4.3098E-3 14 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    cellular protein catabolic process 9.2546E-7 14 171 6 6292
    protein catabolic process 1.6678E-6 14 189 6 6292
    cellular macromolecule catabolic process 1.1911E-5 14 265 6 6292
    modification-dependent protein catabolic process 1.4684E-5 14 156 5 6292
    ubiquitin-dependent protein catabolic process 1.4684E-5 14 156 5 6292
    proteolysis involved in cellular protein catabolic process 1.6112E-5 14 159 5 6292
    modification-dependent macromolecule catabolic process 1.8733E-5 14 164 5 6292
    macromolecule catabolic process 2.1618E-5 14 294 6 6292
    proteolysis 3.6305E-5 14 188 5 6292
    catabolic process 3.8171E-5 14 496 7 6292
    cellular catabolic process 1.5129E-4 14 415 6 6292
    cellular macromolecule metabolic process 2.0876E-4 14 2285 12 6292
    macromolecule metabolic process 2.8291E-4 14 2349 12 6292
    primary metabolic process 3.2929E-4 14 2896 13 6292
    proteasomal protein catabolic process 4.2141E-4 14 69 3 6292
    proteasomal ubiquitin-dependent protein catabolic process 4.2141E-4 14 69 3 6292
    cellular metabolic process 5.8003E-4 14 3033 13 6292
    nucleic acid metabolic process 9.44E-4 14 1415 9 6292
    metabolic process 9.4511E-4 14 3157 13 6292
    glucose metabolic process 1.6019E-3 14 109 3 6292
    transcription from RNA polymerase I promoter 1.9301E-3 14 30 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0587E-3 14 1566 9 6292
    glycogen metabolic process 2.1952E-3 14 32 2 6292
    energy reserve metabolic process 2.1952E-3 14 32 2 6292
    hexose metabolic process 2.32E-3 14 124 3 6292
    monosaccharide metabolic process 2.9566E-3 14 135 3 6292
    ER-associated protein catabolic process 3.2505E-3 14 39 2 6292
    transcription, DNA-dependent 3.4885E-3 14 503 5 6292
    RNA biosynthetic process 3.6431E-3 14 508 5 6292
    energy derivation by oxidation of organic compounds 3.9107E-3 14 149 3 6292
    cellular glucan metabolic process 3.941E-3 14 43 2 6292
    glucan metabolic process 3.941E-3 14 43 2 6292
    cellular protein metabolic process 4.6722E-3 14 1074 7 6292
    cellular nitrogen compound metabolic process 5.1472E-3 14 1770 9 6292
    transcription 5.2299E-3 14 552 5 6292
    nitrogen compound metabolic process 5.6129E-3 14 1791 9 6292
    cellular polysaccharide metabolic process 6.383E-3 14 55 2 6292
    protein metabolic process 6.4609E-3 14 1136 7 6292
    actin nucleation 6.6614E-3 14 3 1 6292
    polysaccharide metabolic process 7.5599E-3 14 60 2 6292
    obsolete_biological_process 7.5599E-3 14 60 2 6292
    generation of precursor metabolites and energy 8.2889E-3 14 195 3 6292
    regulation of initiation of mating projection growth 8.8726E-3 14 4 1 6292
    ubiquitin cycle 8.8726E-3 14 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase activity 5.0397E-5 14 34 3 6292
    DNA-directed RNA polymerase activity 5.0397E-5 14 34 3 6292
    protein phosphatase type 1 regulator activity 2.9963E-4 14 12 2 6292
    protein phosphatase regulator activity 1.1326E-3 14 23 2 6292
    phosphatase regulator activity 1.1326E-3 14 23 2 6292
    nucleotidyltransferase activity 5.4793E-3 14 168 3 6292
    pyruvate decarboxylase activity 8.8726E-3 14 4 1 6292
    enzyme regulator activity 9.7681E-3 14 207 3 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle