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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes: From the published set of protein complexes.
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CDC73
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
    		•
  • DNA recombination
  • histone methylation
  • telomere maintenance
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    CKA1
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 activity
    		•
    CKA2
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 activity
    		•
    CKB1
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 regulator activity
    		•
    CKB2
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 regulator activity
    		•
    CTR9
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
    		•
  • histone methylation
  • transcription from RNA polymerase II promoter
  • chromosome segregation
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
  • triplex DNA binding
    		•
    IML1
  • fungal-type vacuole membrane
    		•
  • biological_process
    		•
  • molecular_function
    		•
    LEO1
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
    		•
  • histone methylation
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    LYS12
  • mitochondrion
    		•
  • lysine biosynthetic process
    		•
  • homoisocitrate dehydrogenase activity
    		•
    PAF1
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
    		•
  • DNA recombination
  • histone methylation
  • telomere maintenance
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    POB3
  • nucleus
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
    		•
  • chromatin remodeling
  • DNA-dependent DNA replication
  • chromatin assembly or disassembly
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
    		•
  • chromatin binding
    		•
    RTF1
  • nucleus
  • transcription elongation factor complex
  • Cdc73/Paf1 complex
    		•
  • histone methylation
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    SPT16
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • transcription elongation factor complex
    		•
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
    		•
  • transcription elongation regulator activity
  • RNA polymerase II transcription elongation factor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription elongation factor complex 5.3766E-15 13 23 7 6292
    Cdc73/Paf1 complex 8.7561E-13 13 8 5 6292
    protein kinase CK2 complex 1.0959E-11 13 4 4 6292
    DNA-directed RNA polymerase II, holoenzyme 5.6753E-8 13 56 5 6292
    nucleoplasm part 1.7512E-7 13 245 7 6292
    nucleoplasm 2.9242E-7 13 264 7 6292
    protein complex 3.513E-7 13 1137 11 6292
    FACT complex 3.9411E-6 13 2 2 6292
    nuclear lumen 1.1227E-5 13 453 7 6292
    macromolecular complex 1.6165E-5 13 1635 11 6292
    alpha DNA polymerase:primase complex 8.2282E-5 13 7 2 6292
    organelle lumen 1.3182E-4 13 660 7 6292
    intracellular organelle lumen 1.3182E-4 13 660 7 6292
    membrane-enclosed lumen 1.9222E-4 13 700 7 6292
    replisome 5.9184E-4 13 18 2 6292
    nuclear replisome 5.9184E-4 13 18 2 6292
    nuclear replication fork 7.3325E-4 13 20 2 6292
    nuclear part 3.207E-3 13 1103 7 6292
    replication fork 3.2387E-3 13 42 2 6292
    protein-DNA complex 5.8994E-3 13 57 2 6292
    nuclear chromatin 9.5347E-3 13 73 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA elongation from RNA polymerase II promoter 3.3283E-13 13 39 7 6292
    RNA elongation 9.7704E-13 13 45 7 6292
    regulation of transcription from RNA polymerase I promoter 1.0959E-11 13 4 4 6292
    transcription, DNA-dependent 5.1753E-11 13 503 11 6292
    RNA biosynthetic process 5.7674E-11 13 508 11 6292
    transcription 1.4308E-10 13 552 11 6292
    histone methylation 2.3935E-10 13 20 5 6292
    regulation of transcription from RNA polymerase III promoter 3.8225E-10 13 7 4 6292
    protein amino acid alkylation 6.5339E-10 13 24 5 6292
    protein amino acid methylation 6.5339E-10 13 24 5 6292
    flocculation via cell wall protein-carbohydrate interaction 2.2857E-9 13 10 4 6292
    post-translational protein modification 3.2269E-9 13 357 9 6292
    flocculation 3.5876E-9 13 11 4 6292
    macromolecule methylation 1.4501E-8 13 43 5 6292
    methylation 1.4501E-8 13 43 5 6292
    one-carbon metabolic process 5.1741E-8 13 55 5 6292
    RNA metabolic process 5.3775E-8 13 954 11 6292
    protein modification process 6.2057E-8 13 499 9 6292
    macromolecule modification 1.9543E-7 13 569 9 6292
    G2/M transition of mitotic cell cycle 2.5293E-7 13 29 4 6292
    homeostatic process 2.8195E-7 13 408 8 6292
    transcription from RNA polymerase I promoter 2.9151E-7 13 30 4 6292
    chromatin modification 4.8712E-7 13 168 6 6292
    cellular biosynthetic process 5.5313E-7 13 1567 12 6292
    cellular macromolecule biosynthetic process 5.5534E-7 13 1187 11 6292
    covalent chromatin modification 5.6249E-7 13 88 5 6292
    histone modification 5.6249E-7 13 88 5 6292
    macromolecule biosynthetic process 5.6537E-7 13 1189 11 6292
    biosynthetic process 7.1688E-7 13 1602 12 6292
    transcription from RNA polymerase III promoter 7.78E-7 13 38 4 6292
    gene expression 1.2671E-6 13 1283 11 6292
    transcription from RNA polymerase II promoter 1.4817E-6 13 335 7 6292
    chromatin organization 1.4885E-6 13 203 6 6292
    cellular nitrogen compound metabolic process 2.3049E-6 13 1770 12 6292
    G1/S transition of mitotic cell cycle 2.3941E-6 13 50 4 6292
    nitrogen compound metabolic process 2.6455E-6 13 1791 12 6292
    regulation of biological quality 2.8512E-6 13 551 8 6292
    nucleic acid metabolic process 3.5616E-6 13 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0311E-5 13 1566 11 6292
    interphase of mitotic cell cycle 3.412E-5 13 97 4 6292
    interphase 3.412E-5 13 97 4 6292
    protein amino acid phosphorylation 4.3238E-5 13 103 4 6292
    cellular protein metabolic process 4.4196E-5 13 1074 9 6292
    protein metabolic process 7.0367E-5 13 1136 9 6292
    cellular chemical homeostasis 7.6233E-5 13 119 4 6292
    cellular ion homeostasis 7.6233E-5 13 119 4 6292
    cellular homeostasis 7.877E-5 13 120 4 6292
    chemical homeostasis 8.6754E-5 13 123 4 6292
    ion homeostasis 8.6754E-5 13 123 4 6292
    multi-organism process 1.5595E-4 13 143 4 6292
    phosphorylation 3.7035E-4 13 179 4 6292
    chromosome organization 4.5859E-4 13 555 6 6292
    cellular macromolecule metabolic process 4.9766E-4 13 2285 11 6292
    macromolecule metabolic process 6.5617E-4 13 2349 11 6292
    primary metabolic process 6.6865E-4 13 2896 12 6292
    phosphorus metabolic process 9.4289E-4 13 229 4 6292
    phosphate metabolic process 9.4289E-4 13 229 4 6292
    biological regulation 9.5169E-4 13 1213 8 6292
    response to DNA damage stimulus 1.0557E-3 13 236 4 6292
    cellular metabolic process 1.1248E-3 13 3033 12 6292
    mitotic cell cycle 1.4101E-3 13 255 4 6292
    metabolic process 1.7612E-3 13 3157 12 6292
    anatomical structure homeostasis 2.1573E-3 13 286 4 6292
    telomere organization 2.1573E-3 13 286 4 6292
    telomere maintenance 2.1573E-3 13 286 4 6292
    cellular response to stress 2.2705E-3 13 290 4 6292
    small molecule metabolic process 2.4645E-3 13 760 6 6292
    transcription initiation from RNA polymerase II promoter 4.0426E-3 13 47 2 6292
    DNA metabolic process 4.6676E-3 13 585 5 6292
    regulation of transcription, DNA-dependent 4.8872E-3 13 358 4 6292
    regulation of RNA metabolic process 5.1368E-3 13 363 4 6292
    cell cycle phase 5.8264E-3 13 376 4 6292
    cellular response to stimulus 5.9941E-3 13 379 4 6292
    transcription initiation 6.103E-3 13 58 2 6292
    regulation of transcription 6.2808E-3 13 384 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.2693E-3 13 415 4 6292
    regulation of nitrogen compound metabolic process 8.3397E-3 13 416 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase II transcription elongation factor activity 3.4023E-14 13 13 6 6292
    transcription elongation regulator activity 5.3486E-13 13 19 6 6292
    protein kinase CK2 activity 3.9411E-6 13 2 2 6292
    protein kinase CK2 regulator activity 3.9411E-6 13 2 2 6292
    obsolete_molecular_function 8.7925E-6 13 69 4 6292
    transcription regulator activity 2.9094E-5 13 339 6 6292
    triplex DNA binding 2.0661E-3 13 1 1 6292
    homoisocitrate dehydrogenase activity 2.0661E-3 13 1 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle