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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CTI6
  • nucleus
  • positive regulation of transcription
  • histone deacetylation
  • histone deacetylase activity
  • transcription factor binding
  • RCO1
  • nucleus
  • histone deacetylase complex
  • histone deacetylation
  • histone deacetylase activity
  • RPD3
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • protein amino acid deacetylation
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • chromatin organization
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • mitotic recombination
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
  • RXT3
  • nucleus
  • chromatin silencing
  • histone deacetylation
  • histone deacetylase activity
  • SAP30
  • histone deacetylase complex
  • chromatin silencing at rDNA
  • telomere maintenance
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • histone deacetylase activity
  • SDS3
  • nucleus
  • Rpd3L-Expanded complex
  • Rpd3L complex
  • chromatin silencing
  • histone deacetylation
  • histone deacetylase activity
  • SIN3
  • Sin3 complex
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
  • UME1
  • nucleus
  • regulation of meiosis
  • histone deacetylation
  • histone deacetylase activity
  • transcription corepressor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylase complex 2.2802E-11 8 23 5 6292
    chromatin remodeling complex 4.7014E-8 8 99 5 6292
    nucleoplasm part 4.3736E-6 8 245 5 6292
    nucleoplasm 6.3232E-6 8 264 5 6292
    Sin3-type complex 1.4121E-5 8 5 2 6292
    nuclear lumen 8.8346E-5 8 453 5 6292
    nucleus 1.2145E-4 8 2041 8 6292
    organelle lumen 5.3463E-4 8 660 5 6292
    intracellular organelle lumen 5.3463E-4 8 660 5 6292
    membrane-enclosed lumen 7.0576E-4 8 700 5 6292
    Rpd3L complex 1.2715E-3 8 1 1 6292
    Rpd3L-Expanded complex 1.2715E-3 8 1 1 6292
    nuclear chromatin 3.5536E-3 8 73 2 6292
    chromatin 3.9464E-3 8 77 2 6292
    Sin3 complex 5.0773E-3 8 4 1 6292
    nuclear part 5.7545E-3 8 1103 5 6292
    protein complex 6.5954E-3 8 1137 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylation 3.6603E-20 8 27 8 6292
    protein amino acid deacetylation 7.0765E-20 8 29 8 6292
    covalent chromatin modification 1.0597E-15 8 88 8 6292
    histone modification 1.0597E-15 8 88 8 6292
    chromatin modification 2.1909E-13 8 168 8 6292
    chromatin organization 1.0255E-12 8 203 8 6292
    post-translational protein modification 9.9693E-11 8 357 8 6292
    protein modification process 1.4857E-9 8 499 8 6292
    chromosome organization 3.4991E-9 8 555 8 6292
    macromolecule modification 4.2762E-9 8 569 8 6292
    negative regulation of gene expression, epigenetic 4.9469E-8 8 100 5 6292
    gene silencing 4.9469E-8 8 100 5 6292
    regulation of gene expression, epigenetic 4.9469E-8 8 100 5 6292
    chromatin silencing 4.9469E-8 8 100 5 6292
    negative regulation of transcription, DNA-dependent 4.7863E-7 8 157 5 6292
    negative regulation of RNA metabolic process 4.9407E-7 8 158 5 6292
    negative regulation of transcription 5.9524E-7 8 164 5 6292
    negative regulation of gene expression 5.9524E-7 8 164 5 6292
    cellular protein metabolic process 7.0519E-7 8 1074 8 6292
    negative regulation of macromolecule biosynthetic process 8.2303E-7 8 175 5 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.4712E-7 8 180 5 6292
    negative regulation of nitrogen compound metabolic process 9.4712E-7 8 180 5 6292
    organelle organization 1.038E-6 8 1127 8 6292
    chromatin silencing at rDNA 1.0914E-6 8 18 3 6292
    protein metabolic process 1.1064E-6 8 1136 8 6292
    negative regulation of biosynthetic process 1.2076E-6 8 189 5 6292
    negative regulation of cellular biosynthetic process 1.2076E-6 8 189 5 6292
    regulation of transcription 1.2545E-6 8 384 6 6292
    negative regulation of macromolecule metabolic process 1.3061E-6 8 192 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.9869E-6 8 415 6 6292
    negative regulation of cellular metabolic process 1.9909E-6 8 209 5 6292
    regulation of nitrogen compound metabolic process 2.0153E-6 8 416 6 6292
    negative regulation of metabolic process 2.0386E-6 8 210 5 6292
    regulation of gene expression 3.0015E-6 8 445 6 6292
    regulation of macromolecule biosynthetic process 3.4669E-6 8 456 6 6292
    regulation of cellular process 3.609E-6 8 796 7 6292
    regulation of cellular biosynthetic process 4.2489E-6 8 472 6 6292
    regulation of biosynthetic process 4.3022E-6 8 473 6 6292
    regulation of biological process 4.5811E-6 8 824 7 6292
    negative regulation of cellular process 4.8326E-6 8 250 5 6292
    negative regulation of biological process 5.1258E-6 8 253 5 6292
    regulation of macromolecule metabolic process 5.171E-6 8 488 6 6292
    regulation of primary metabolic process 7.018E-6 8 514 6 6292
    chromatin silencing at silent mating-type cassette 7.2323E-6 8 33 3 6292
    regulation of cellular metabolic process 8.9774E-6 8 536 6 6292
    regulation of metabolic process 1.0114E-5 8 547 6 6292
    transcription 1.0669E-5 8 552 6 6292
    cellular component organization 1.5761E-5 8 1582 8 6292
    regulation of transcription, DNA-dependent 2.8172E-5 8 358 5 6292
    regulation of RNA metabolic process 3.0144E-5 8 363 5 6292
    chromatin silencing at telomere 3.4321E-5 8 55 3 6292
    biological regulation 6.4966E-5 8 1213 7 6292
    transcription, DNA-dependent 1.4632E-4 8 503 5 6292
    RNA biosynthetic process 1.5345E-4 8 508 5 6292
    positive regulation of transcription 2.8813E-4 8 112 3 6292
    positive regulation of gene expression 2.8813E-4 8 112 3 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.3621E-4 8 118 3 6292
    positive regulation of nitrogen compound metabolic process 3.3621E-4 8 118 3 6292
    positive regulation of macromolecule biosynthetic process 3.3621E-4 8 118 3 6292
    positive regulation of biosynthetic process 3.6209E-4 8 121 3 6292
    positive regulation of cellular biosynthetic process 3.6209E-4 8 121 3 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    positive regulation of macromolecule metabolic process 4.0804E-4 8 126 3 6292
    double-strand break repair via nonhomologous end joining 4.1826E-4 8 25 2 6292
    positive regulation of metabolic process 4.3734E-4 8 129 3 6292
    positive regulation of cellular metabolic process 4.3734E-4 8 129 3 6292
    positive regulation of cellular process 5.1092E-4 8 136 3 6292
    positive regulation of biological process 5.2205E-4 8 137 3 6292
    non-recombinational repair 7.7767E-4 8 34 2 6292
    cellular macromolecule biosynthetic process 8.7999E-4 8 1187 6 6292
    macromolecule biosynthetic process 8.8836E-4 8 1189 6 6292
    gene expression 1.3613E-3 8 1283 6 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    double-strand break repair 2.1802E-3 8 57 2 6292
    nucleic acid metabolic process 2.3473E-3 8 1415 6 6292
    negative regulation of transcription from RNA polymerase II promoter 2.4133E-3 8 60 2 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    RNA metabolic process 2.9766E-3 8 954 5 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1016E-3 8 1566 6 6292
    cellular biosynthetic process 4.1159E-3 8 1567 6 6292
    biosynthetic process 4.6438E-3 8 1602 6 6292
    positive regulation of transcription from RNA polymerase II promoter 4.6808E-3 8 84 2 6292
    positive regulation of transcription, DNA-dependent 6.9683E-3 8 103 2 6292
    positive regulation of RNA metabolic process 7.5036E-3 8 107 2 6292
    cellular nitrogen compound metabolic process 7.9712E-3 8 1770 6 6292
    nitrogen compound metabolic process 8.4927E-3 8 1791 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylase activity 1.7342E-19 8 32 8 6292
    protein deacetylase activity 1.7342E-19 8 32 8 6292
    deacetylase activity 3.8804E-19 8 35 8 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6.2214E-18 8 48 8 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4.7792E-16 8 80 8 6292
    transcription factor binding 1.298E-7 8 43 4 6292
    hydrolase activity 1.881E-7 8 911 8 6292
    transcription corepressor activity 7.4989E-7 8 16 3 6292
    transcription cofactor activity 1.3042E-5 8 40 3 6292
    transcription repressor activity 1.7441E-5 8 44 3 6292
    catalytic activity 1.8428E-4 8 2150 8 6292
    transcription coactivator activity 2.9353E-4 8 21 2 6292
    transcription activator activity 2.4935E-3 8 61 2 6292
    protein binding 4.508E-3 8 612 4 6292
    transcription regulator activity 7.087E-3 8 339 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle