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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRE2
  • Set1C/COMPASS complex
  • transcription
  • histone methylation
  • telomere maintenance
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • transcription regulator activity
  • ERF2
  • integral to endoplasmic reticulum membrane
  • palmitoyltransferase complex
  • protein amino acid palmitoylation
  • protein targeting to membrane
  • protein-cysteine S-palmitoleyltransferase activity
  • SDC1
  • Set1C/COMPASS complex
  • histone methylation
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • SET1
  • Set1C/COMPASS complex
  • ascospore formation
  • chromatin silencing at rDNA
  • histone methylation
  • telomere maintenance
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • peptidyl-lysine dimethylation
  • histone methyltransferase activity (H3-K4 specific)
  • histone methyltransferase activity
  • protein-lysine N-methyltransferase activity
  • SHG1
  • Set1C/COMPASS complex
  • nucleus
  • histone methylation
  • histone methyltransferase activity (H3-K4 specific)
  • SPP1
  • Set1C/COMPASS complex
  • histone methylation
  • regulation of transcription, DNA-dependent
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • SWD1
  • Set1C/COMPASS complex
  • histone methylation
  • telomere maintenance
  • regulation of transcription, DNA-dependent
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • SWD3
  • Set1C/COMPASS complex
  • histone methylation
  • telomere maintenance
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • YHI9
  • cellular_component
  • biological_process
  • molecular_function
  • YLL023C
  • endoplasmic reticulum
  • ribosome
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Set1C/COMPASS complex 1.2429E-20 10 8 7 6292
    methyltransferase complex 1.2429E-20 10 8 7 6292
    histone methyltransferase complex 1.2429E-20 10 8 7 6292
    chromatin remodeling complex 2.2262E-11 10 99 7 6292
    nucleoplasm part 1.3547E-8 10 245 7 6292
    nucleoplasm 2.2806E-8 10 264 7 6292
    nuclear lumen 9.5088E-7 10 453 7 6292
    organelle lumen 1.2248E-5 10 660 7 6292
    intracellular organelle lumen 1.2248E-5 10 660 7 6292
    membrane-enclosed lumen 1.8187E-5 10 700 7 6292
    protein complex 3.542E-5 10 1137 8 6292
    macromolecular complex 4.0767E-5 10 1635 9 6292
    nuclear part 3.6626E-4 10 1103 7 6292
    organelle part 6.1675E-3 10 2282 8 6292
    intracellular organelle part 6.1675E-3 10 2282 8 6292
    palmitoyltransferase complex 6.3436E-3 10 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone methylation 1.1984E-16 10 20 7 6292
    protein amino acid alkylation 5.3415E-16 10 24 7 6292
    protein amino acid methylation 5.3415E-16 10 24 7 6292
    macromolecule methylation 4.9337E-14 10 43 7 6292
    methylation 4.9337E-14 10 43 7 6292
    one-carbon metabolic process 3.0913E-13 10 55 7 6292
    covalent chromatin modification 9.5373E-12 10 88 7 6292
    histone modification 9.5373E-12 10 88 7 6292
    chromatin silencing at telomere 6.8937E-11 10 55 6 6292
    chromatin modification 9.5884E-10 10 168 7 6292
    negative regulation of gene expression, epigenetic 2.7653E-9 10 100 6 6292
    gene silencing 2.7653E-9 10 100 6 6292
    regulation of gene expression, epigenetic 2.7653E-9 10 100 6 6292
    chromatin silencing 2.7653E-9 10 100 6 6292
    chromatin organization 3.6319E-9 10 203 7 6292
    negative regulation of transcription, DNA-dependent 4.2443E-8 10 157 6 6292
    negative regulation of RNA metabolic process 4.4094E-8 10 158 6 6292
    negative regulation of transcription 5.5156E-8 10 164 6 6292
    negative regulation of gene expression 5.5156E-8 10 164 6 6292
    protein modification process 5.7896E-8 10 499 8 6292
    negative regulation of macromolecule biosynthetic process 8.1405E-8 10 175 6 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.6361E-8 10 180 6 6292
    negative regulation of nitrogen compound metabolic process 9.6361E-8 10 180 6 6292
    negative regulation of biosynthetic process 1.2901E-7 10 189 6 6292
    negative regulation of cellular biosynthetic process 1.2901E-7 10 189 6 6292
    negative regulation of macromolecule metabolic process 1.4173E-7 10 192 6 6292
    macromolecule modification 1.6311E-7 10 569 8 6292
    post-translational protein modification 1.8495E-7 10 357 7 6292
    negative regulation of cellular metabolic process 2.3508E-7 10 209 6 6292
    negative regulation of metabolic process 2.4186E-7 10 210 6 6292
    negative regulation of cellular process 6.8106E-7 10 250 6 6292
    negative regulation of biological process 7.3088E-7 10 253 6 6292
    chromosome organization 3.7966E-6 10 555 7 6292
    regulation of transcription, DNA-dependent 5.626E-6 10 358 6 6292
    regulation of RNA metabolic process 6.1004E-6 10 363 6 6292
    regulation of transcription 8.466E-6 10 384 6 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.329E-5 10 415 6 6292
    regulation of nitrogen compound metabolic process 1.3477E-5 10 416 6 6292
    regulation of gene expression 1.9904E-5 10 445 6 6292
    cellular protein metabolic process 2.2894E-5 10 1074 8 6292
    regulation of macromolecule biosynthetic process 2.2918E-5 10 456 6 6292
    regulation of cellular biosynthetic process 2.7958E-5 10 472 6 6292
    regulation of biosynthetic process 2.83E-5 10 473 6 6292
    small molecule metabolic process 3.1532E-5 10 760 7 6292
    regulation of macromolecule metabolic process 3.3868E-5 10 488 6 6292
    protein metabolic process 3.5183E-5 10 1136 8 6292
    transcription, DNA-dependent 4.0298E-5 10 503 6 6292
    RNA biosynthetic process 4.2651E-5 10 508 6 6292
    regulation of primary metabolic process 4.562E-5 10 514 6 6292
    regulation of cellular metabolic process 5.7984E-5 10 536 6 6292
    regulation of metabolic process 6.5117E-5 10 547 6 6292
    transcription 6.8587E-5 10 552 6 6292
    organelle organization 4.2101E-4 10 1127 7 6292
    regulation of cellular process 5.3772E-4 10 796 6 6292
    cellular macromolecule biosynthetic process 5.882E-4 10 1187 7 6292
    macromolecule biosynthetic process 5.946E-4 10 1189 7 6292
    regulation of biological process 6.5093E-4 10 824 6 6292
    anatomical structure homeostasis 7.0621E-4 10 286 4 6292
    telomere organization 7.0621E-4 10 286 4 6292
    telomere maintenance 7.0621E-4 10 286 4 6292
    RNA metabolic process 1.451E-3 10 954 6 6292
    peptidyl-lysine dimethylation 1.5893E-3 10 1 1 6292
    homeostatic process 2.6729E-3 10 408 4 6292
    peptidyl-lysine methylation 3.1764E-3 10 2 1 6292
    cellular biosynthetic process 3.3987E-3 10 1567 7 6292
    cellular component organization 3.6048E-3 10 1582 7 6292
    biosynthetic process 3.8954E-3 10 1602 7 6292
    peptidyl-lysine modification 4.7611E-3 10 3 1 6292
    biological regulation 5.2241E-3 10 1213 6 6292
    cellular macromolecule metabolic process 6.225E-3 10 2285 8 6292
    gene expression 6.9959E-3 10 1283 6 6292
    macromolecule metabolic process 7.5629E-3 10 2349 8 6292
    regulation of biological quality 7.9592E-3 10 551 4 6292
    DNA metabolic process 9.8454E-3 10 585 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone methyltransferase activity (H3-K4 specific) 1.2429E-20 10 8 7 6292
    histone methyltransferase activity 5.5909E-20 10 9 7 6292
    histone-lysine N-methyltransferase activity 5.5909E-20 10 9 7 6292
    lysine N-methyltransferase activity 2.6605E-18 10 13 7 6292
    protein-lysine N-methyltransferase activity 2.6605E-18 10 13 7 6292
    protein methyltransferase activity 1.1984E-16 10 20 7 6292
    N-methyltransferase activity 7.4156E-16 10 25 7 6292
    S-adenosylmethionine-dependent methyltransferase activity 1.3181E-12 10 67 7 6292
    methyltransferase activity 1.7846E-11 10 96 7 6292
    transferase activity, transferring one-carbon groups 2.2262E-11 10 99 7 6292
    transferase activity 2.2829E-6 10 797 8 6292
    catalytic activity 4.0379E-3 10 2150 8 6292

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