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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CBC2
  • commitment complex
  • nuclear cap binding complex
    		•
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA cap binding
    		•
    KAP95
  • cytoplasm
  • nuclear pore
    		•
  • protein import into nucleus
  • nuclear pore complex assembly
    		•
  • protein transmembrane transporter activity
    		•
    NUP1
  • nuclear pore
    		•
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear envelope organization
  • RNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • protein import into nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
    		•
  • protein binding
  • structural molecule activity
    		•
    NUP2
  • nuclear chromatin
  • mitochondrion
  • nuclear pore
    		•
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • chromatin silencing
  • protein export from nucleus
  • chromatin silencing at telomere
  • ribosomal protein import into nucleus
    		•
  • structural molecule activity
    		•
    NUP60
  • nuclear pore
    		•
  • nucleocytoplasmic transport
  • telomere maintenance
  • protein import into nucleus, docking
    		•
  • structural constituent of nuclear pore
    		•
    OGG1
  • mitochondrion
    		•
  • DNA repair
  • base-excision repair, AP site formation
  • telomere maintenance
    		•
  • oxidized purine base lesion DNA N-glycosylase activity
    		•
    PCT1
  • nuclear envelope
  • nucleus
  • Golgi apparatus
    		•
  • CDP-choline pathway
  • phosphatidylcholine biosynthetic process
    		•
  • choline-phosphate cytidylyltransferase activity
    		•
    RAD53
  • nucleus
    		•
  • DNA replication initiation
  • DNA repair
  • deoxyribonucleoside triphosphate biosynthetic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
    		•
  • DNA replication origin binding
  • protein serine/threonine/tyrosine kinase activity
    		•
    SRP1
  • nucleus
  • cytoplasm
    		•
  • nucleocytoplasmic transport
    		•
  • protein transmembrane transporter activity
    		•
    STO1
  • commitment complex
  • nuclear cap binding complex
    		•
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•
    ULP1
  • nuclear envelope
  • nuclear pore
    		•
  • G2/M transition of mitotic cell cycle
  • protein desumoylation
    		•
  • SUMO-specific protease activity
  • cysteine-type peptidase activity
    		•
    URB2
  • nucleolus
    		•
  • rRNA metabolic process
  • ribosome biogenesis
    		•
  • molecular_function
    		•
    YRA2
  • nucleus
    		•
  • poly(A)+ mRNA export from nucleus
    		•
  • RNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pore complex 3.8779E-8 13 52 5 6292
    nuclear pore 3.8779E-8 13 52 5 6292
    nuclear envelope 1.3241E-6 13 199 6 6292
    nuclear cap binding complex 1.1809E-5 13 3 2 6292
    nucleus 1.2114E-5 13 2041 12 6292
    nuclear part 5.5135E-5 13 1103 9 6292
    RNA cap binding complex 5.8841E-5 13 6 2 6292
    endomembrane system 7.2314E-5 13 398 6 6292
    integral to membrane 1.0355E-4 13 255 5 6292
    intrinsic to membrane 1.1779E-4 13 262 5 6292
    U2-type spliceosomal complex 2.571E-4 13 12 2 6292
    commitment complex 2.571E-4 13 12 2 6292
    envelope 2.7311E-4 13 505 6 6292
    organelle envelope 2.7311E-4 13 505 6 6292
    membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular organelle 3.4477E-3 13 4070 13 6292
    organelle 3.4587E-3 13 4071 13 6292
    spliceosomal complex 3.7109E-3 13 45 2 6292
    protein complex 3.8397E-3 13 1137 7 6292
    membrane part 7.9545E-3 13 662 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear transport 1.0564E-7 13 130 6 6292
    nucleocytoplasmic transport 1.0564E-7 13 130 6 6292
    protein localization in nucleus 2.0274E-6 13 48 4 6292
    protein import into nucleus 2.0274E-6 13 48 4 6292
    nuclear import 2.0274E-6 13 48 4 6292
    nuclear pore organization 2.1915E-5 13 28 3 6292
    protein import 5.2107E-5 13 108 4 6292
    nucleus organization 1.7933E-4 13 56 3 6292
    protein localization in organelle 1.8285E-4 13 149 4 6292
    mRNA export from nucleus 3.1959E-4 13 68 3 6292
    mRNA transport 3.1959E-4 13 68 3 6292
    intracellular transport 4.4964E-4 13 553 6 6292
    RNA export from nucleus 5.1647E-4 13 80 3 6292
    RNA transport 5.3569E-4 13 81 3 6292
    nucleic acid transport 5.3569E-4 13 81 3 6292
    establishment of RNA localization 5.3569E-4 13 81 3 6292
    establishment of localization in cell 6.943E-4 13 599 6 6292
    RNA localization 7.7815E-4 13 92 3 6292
    macromolecule localization 8.2204E-4 13 397 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid transport 8.8111E-4 13 96 3 6292
    ribosomal protein import into nucleus 9.7297E-4 13 23 2 6292
    snRNP protein import into nucleus 9.7297E-4 13 23 2 6292
    NLS-bearing substrate import into nucleus 9.7297E-4 13 23 2 6292
    snRNA export from nucleus 9.7297E-4 13 23 2 6292
    snRNA transport 9.7297E-4 13 23 2 6292
    cellular localization 1.017E-3 13 643 6 6292
    protein targeting 1.0391E-3 13 235 4 6292
    nuclear export 1.0815E-3 13 103 3 6292
    mRNA-binding (hnRNP) protein import into nucleus 1.151E-3 13 25 2 6292
    rRNA export from nucleus 1.3436E-3 13 27 2 6292
    rRNA transport 1.3436E-3 13 27 2 6292
    intracellular protein transport 1.4101E-3 13 255 4 6292
    tRNA export from nucleus 1.4452E-3 13 28 2 6292
    tRNA transport 1.4452E-3 13 28 2 6292
    cellular macromolecular complex subunit organization 1.4943E-3 13 259 4 6292
    protein transport 1.72E-3 13 269 4 6292
    establishment of protein localization 1.7679E-3 13 271 4 6292
    cellular protein localization 1.8414E-3 13 274 4 6292
    protein export from nucleus 1.8876E-3 13 32 2 6292
    pore complex assembly 2.0661E-3 13 1 1 6292
    nuclear pore complex assembly 2.0661E-3 13 1 1 6292
    CDP-choline pathway 2.0661E-3 13 1 1 6292
    cellular macromolecule localization 2.1022E-3 13 284 4 6292
    anatomical structure homeostasis 2.1573E-3 13 286 4 6292
    telomere organization 2.1573E-3 13 286 4 6292
    telomere maintenance 2.1573E-3 13 286 4 6292
    protein localization 2.6673E-3 13 303 4 6292
    organelle organization 3.6442E-3 13 1127 7 6292
    deoxyribonucleoside triphosphate biosynthetic process 4.1283E-3 13 2 1 6292
    protein desumoylation 4.1283E-3 13 2 1 6292
    DNA metabolic process 4.6676E-3 13 585 5 6292
    macromolecular complex subunit organization 4.8383E-3 13 357 4 6292
    cellular protein complex assembly 5.308E-3 13 54 2 6292
    base-excision repair, AP site formation 6.1865E-3 13 3 1 6292
    homeostatic process 7.7877E-3 13 408 4 6292
    protein import into nucleus, docking 8.2408E-3 13 4 1 6292
    deoxyribonucleoside triphosphate metabolic process 8.2408E-3 13 4 1 6292
    deoxyribonucleotide biosynthetic process 8.2408E-3 13 4 1 6292
    cellular component biogenesis 9.7186E-3 13 694 5 6292
    transport 9.8122E-3 13 997 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein transmembrane transporter activity 1.4073E-4 13 9 2 6292
    macromolecule transmembrane transporter activity 1.4073E-4 13 9 2 6292
    choline-phosphate cytidylyltransferase activity 2.0661E-3 13 1 1 6292
    RNA cap binding 4.1283E-3 13 2 1 6292
    SUMO-specific protease activity 4.1283E-3 13 2 1 6292
    oxidized purine base lesion DNA N-glycosylase activity 4.1283E-3 13 2 1 6292
    protein transporter activity 6.103E-3 13 58 2 6292
    cytidylyltransferase activity 6.1865E-3 13 3 1 6292
    oxidized base lesion DNA N-glycosylase activity 6.1865E-3 13 3 1 6292
    binding 8.1545E-3 13 1294 7 6292
    structural constituent of nuclear pore 8.2408E-3 13 4 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle